NR 546 Week 3
Antipsychotics Table Assignments .
,Drug name Indication Half-life Notable side effects (associate to pathway or
Target symptoms: state if positive or (T1/2), NT)
negative effect Potency (if noted. receptor metabolism
occupancy if noted ) Neurotransmitter(s) (CYP 450
affected enzyme)
Typical antipsychotics (conventional)
Haloperidol Blocks dopamine 2 receptors, reducing Decanoate Acute blockade of dopamine 2 receptors
positive symptoms of psychosis and possibly half-life in the striatum can cause drug-induced
combative, explosive, and hyperactive approximat parkinsonism,dystonia, or akathisia
behaviors Blocks dopamine 2 receptors in the ely3 weeks Chronic blockade of dopamine 2
nigrostriatal pathway, improving tics and other Oral half- receptors in the striatum can cause tardive
symptoms in Tourette’s syndrome. life dyskinesia
approximat By blocking dopamine 2 receptors in the
ely12–38 pituitary, it can cause elevations in prolactin
hours By blocking dopamine 2 receptors
excessively in the mesocortical and
mesolimbic dopamine pathways,
especially at high doses, it can cause
worsening of negative and cognitive
symptoms (neuroleptic-induced deficit
syndrome).
Blocking alpha 1 adrenergic receptors can
cause
dizziness, hypotension, and syncope
, Thioridazine Blocks dopamine 2 receptors, reducing Metabolized Acute blockade of dopamine 2 receptors
positive symptoms of psychosis by CYP450 in the striatum can cause drug-induced
2D6 parkinsonism,dystonia, or akathisia.
Chronic blockade of dopamine 2
receptors in the striatum can cause tardive
dyskinesia
By blocking dopamine 2 receptors in the
pituitary, it can cause elevations in
prolactin
By blocking dopamine 2 receptors
excessively in the mesocortical and
mesolimbic dopamine pathways,
especially at high doses, it can cause
worsening of negative and cognitive
symptoms (neuroleptic-induced deficit
syndrome)
Blocking muscarinic cholinergic receptors
can
Antipsychotics Table Assignments .
,Drug name Indication Half-life Notable side effects (associate to pathway or
Target symptoms: state if positive or (T1/2), NT)
negative effect Potency (if noted. receptor metabolism
occupancy if noted ) Neurotransmitter(s) (CYP 450
affected enzyme)
Typical antipsychotics (conventional)
Haloperidol Blocks dopamine 2 receptors, reducing Decanoate Acute blockade of dopamine 2 receptors
positive symptoms of psychosis and possibly half-life in the striatum can cause drug-induced
combative, explosive, and hyperactive approximat parkinsonism,dystonia, or akathisia
behaviors Blocks dopamine 2 receptors in the ely3 weeks Chronic blockade of dopamine 2
nigrostriatal pathway, improving tics and other Oral half- receptors in the striatum can cause tardive
symptoms in Tourette’s syndrome. life dyskinesia
approximat By blocking dopamine 2 receptors in the
ely12–38 pituitary, it can cause elevations in prolactin
hours By blocking dopamine 2 receptors
excessively in the mesocortical and
mesolimbic dopamine pathways,
especially at high doses, it can cause
worsening of negative and cognitive
symptoms (neuroleptic-induced deficit
syndrome).
Blocking alpha 1 adrenergic receptors can
cause
dizziness, hypotension, and syncope
, Thioridazine Blocks dopamine 2 receptors, reducing Metabolized Acute blockade of dopamine 2 receptors
positive symptoms of psychosis by CYP450 in the striatum can cause drug-induced
2D6 parkinsonism,dystonia, or akathisia.
Chronic blockade of dopamine 2
receptors in the striatum can cause tardive
dyskinesia
By blocking dopamine 2 receptors in the
pituitary, it can cause elevations in
prolactin
By blocking dopamine 2 receptors
excessively in the mesocortical and
mesolimbic dopamine pathways,
especially at high doses, it can cause
worsening of negative and cognitive
symptoms (neuroleptic-induced deficit
syndrome)
Blocking muscarinic cholinergic receptors
can
