Neurotransmitter Table
* To be completed throughout course and submitted in
Week 8*
Neuro Recept Location/Function/Effe Distributi Drug classes that Specific medications that
transmitt or cts on (ie: target this target thisneurotransmitter or
er Subtyp /symptoms of CNS/PNS, neurotransmitter receptor
e excess ordeficit if GI, vascular) or
applicable receptor
Glutamate AMPA Ligand-gated ion CNS NMDA glutamate Memantine
channels Modulates antagonist PCP
cell excitability by Barbituates Ketamine
allowing the flow of Antiepileptics Dextromethorp
calcium and sodium han
ions into the cell. Dextromethado
Located at the CNS ne Parampanel
in neurons and glia.
Excess has resulted
in schizophrenia,
epilepsy, and mania.
, NMDA Ligand-gated ion CNS NMDA Memantine
channels, strengthens receptor Amantadine
synapses and involved antagonist Ketamine
in strong memory Antipsychotic Dextromethorpha
formation. Excess is s Loop n Methadone
associated with Diuretics Dextropropoxyph
memory and learning Opiates ene
impairments, Antidepressa Ketobemidone
psychosis, and nts Furosemide
excitotoxic brain injury. Haldol
Tramadol
GABA GABA a Ligand-gated ion CNS Benzodiazepines Lorazepam, Clonazepam,
Limbic system
channels Functions as Hypnotics Alprazolam Zolpidem,
Striatum
postsynaptic inhibition Neuroactive Zopiclone, zaleplon
Medulla
by CI-influx Inotropic steroids Allopregnanolone
Spinal Cord
receptor
Reduces fear, anxiety,
and
, convulsions Pancreas
GABA b G-Protein Linked CNS/PNS GABA-b receptor Baclofen
Functions as pre- agonists, Arbaclofen
synaptic inhibition by Antispastic Placarbil
lowering calcium ion Anesthetics Propofol
entry while post-
synaptic inhibitions
by increasing
potassium ion
permeability
Reduces fear, anxiety,
and convulsions
Serotoni 5HT 1a Somatodendritic Cerebral SSRIs, SNRIs, Buspirone
n 5HT auto receptors Cortex SGAs, FGAs, Clozapine
Inhibits actions of 5HT Midbrain MAOIs, TCAs, Trazodone
neurons pre- raphe Mood stabilizers Lurasidone
synaptically and other Hippocampu Quetiapine
NTs post- synaptically. s Amygdala Valproate
Located on cell body Basal Lithium
and dendrites in the Ganglia Brexpiprazo
midbrain raphe Thalamus le
Targets: anxiety, Found on Aripiprazol
depression, negative GABA neurons e
symptoms in Cariprazine
schizophrenia, Vortioxeten
decreases sexual e
* To be completed throughout course and submitted in
Week 8*
Neuro Recept Location/Function/Effe Distributi Drug classes that Specific medications that
transmitt or cts on (ie: target this target thisneurotransmitter or
er Subtyp /symptoms of CNS/PNS, neurotransmitter receptor
e excess ordeficit if GI, vascular) or
applicable receptor
Glutamate AMPA Ligand-gated ion CNS NMDA glutamate Memantine
channels Modulates antagonist PCP
cell excitability by Barbituates Ketamine
allowing the flow of Antiepileptics Dextromethorp
calcium and sodium han
ions into the cell. Dextromethado
Located at the CNS ne Parampanel
in neurons and glia.
Excess has resulted
in schizophrenia,
epilepsy, and mania.
, NMDA Ligand-gated ion CNS NMDA Memantine
channels, strengthens receptor Amantadine
synapses and involved antagonist Ketamine
in strong memory Antipsychotic Dextromethorpha
formation. Excess is s Loop n Methadone
associated with Diuretics Dextropropoxyph
memory and learning Opiates ene
impairments, Antidepressa Ketobemidone
psychosis, and nts Furosemide
excitotoxic brain injury. Haldol
Tramadol
GABA GABA a Ligand-gated ion CNS Benzodiazepines Lorazepam, Clonazepam,
Limbic system
channels Functions as Hypnotics Alprazolam Zolpidem,
Striatum
postsynaptic inhibition Neuroactive Zopiclone, zaleplon
Medulla
by CI-influx Inotropic steroids Allopregnanolone
Spinal Cord
receptor
Reduces fear, anxiety,
and
, convulsions Pancreas
GABA b G-Protein Linked CNS/PNS GABA-b receptor Baclofen
Functions as pre- agonists, Arbaclofen
synaptic inhibition by Antispastic Placarbil
lowering calcium ion Anesthetics Propofol
entry while post-
synaptic inhibitions
by increasing
potassium ion
permeability
Reduces fear, anxiety,
and convulsions
Serotoni 5HT 1a Somatodendritic Cerebral SSRIs, SNRIs, Buspirone
n 5HT auto receptors Cortex SGAs, FGAs, Clozapine
Inhibits actions of 5HT Midbrain MAOIs, TCAs, Trazodone
neurons pre- raphe Mood stabilizers Lurasidone
synaptically and other Hippocampu Quetiapine
NTs post- synaptically. s Amygdala Valproate
Located on cell body Basal Lithium
and dendrites in the Ganglia Brexpiprazo
midbrain raphe Thalamus le
Targets: anxiety, Found on Aripiprazol
depression, negative GABA neurons e
symptoms in Cariprazine
schizophrenia, Vortioxeten
decreases sexual e
