PCB4233 Exam 1
cytokines
___________ are small soluble proteins produced by many immune cells and are a way of
communication between cells
cytokines
TLR, NLR or RLR
A PRR that lead to mostly activation
TLR, NLR or RLR
myeloid
__________: gives rise to eosinophils, neutrophils and monocytes
myeloid
lymphoid
__________: gives rise to T, B and NK cells
lymphoid
scavenger, lectin
A PRR that lead mostly to phagocytosis
scavenger, lectin
IFN
_________ are cytokines that interfere with viral replication, increase MHC I expression,
activate DC, MACs and NK cells
IFN
MHC I
NK cells have activating and inhibitory receptors at their surface. _________ is the main
,ligand of the inhibitory receptors.
MHC I
death receptor; granule
NK cells kill infected cells by 2 ways: _______________-dependent killing & _______________-
dependent killing
death receptor; granule
DC
The innate immunity plays a critical role in initiating an adaptive immune response
tailored to the ongoing infection. The cell playing this critical link by presenting the
antigen to the naive T cell is ______________.
DC
Alternative pathway
_______________: in this pathway the key activator is the spontaneous hydrolysis of C3
Alternative pathway
lectin pathway
______________: in this pathway the key activator is mannose residues recognized by the
mannose binding lectin
lectin pathway
classical pathway
_____________: in this pathway the key activator is antibodies bound to the pathogen
recognized by the C1 complex
classical pathway
MAC
major activity in all pathways includes formation of a pore in the pathogen called
___________
MAC
, Opsonin
major activity in all pathways includes C3b deposition on the pathogen which acts as an
__________
Opsonin
anaphylatoxins
major activity in all pathways includes release of C5a and C3a in the circulation which act
as ______________
anaphylatoxins
somatic recombination
________________:in primary gene rearrangements a random V, D and J segments are
brought together
somatic recombination
junctional diversity
________________: in primary gene rearrangement additional diversity added by TdT
junctional diversity
somatic hypermutation
________________: in secondary gene rearrangements, increases the recognition of the BCR
for its antigen
somatic hypermutation
class switching
________________: in secondary gene rearrangements, affects the effector function of the
BCR without modifying its ability to recognize the antigen
class switching
heavy; beta
The D segments are found in the __________ chain of the BCR and the __________ chain of
the TCR
heavy; beta
cytokines
___________ are small soluble proteins produced by many immune cells and are a way of
communication between cells
cytokines
TLR, NLR or RLR
A PRR that lead to mostly activation
TLR, NLR or RLR
myeloid
__________: gives rise to eosinophils, neutrophils and monocytes
myeloid
lymphoid
__________: gives rise to T, B and NK cells
lymphoid
scavenger, lectin
A PRR that lead mostly to phagocytosis
scavenger, lectin
IFN
_________ are cytokines that interfere with viral replication, increase MHC I expression,
activate DC, MACs and NK cells
IFN
MHC I
NK cells have activating and inhibitory receptors at their surface. _________ is the main
,ligand of the inhibitory receptors.
MHC I
death receptor; granule
NK cells kill infected cells by 2 ways: _______________-dependent killing & _______________-
dependent killing
death receptor; granule
DC
The innate immunity plays a critical role in initiating an adaptive immune response
tailored to the ongoing infection. The cell playing this critical link by presenting the
antigen to the naive T cell is ______________.
DC
Alternative pathway
_______________: in this pathway the key activator is the spontaneous hydrolysis of C3
Alternative pathway
lectin pathway
______________: in this pathway the key activator is mannose residues recognized by the
mannose binding lectin
lectin pathway
classical pathway
_____________: in this pathway the key activator is antibodies bound to the pathogen
recognized by the C1 complex
classical pathway
MAC
major activity in all pathways includes formation of a pore in the pathogen called
___________
MAC
, Opsonin
major activity in all pathways includes C3b deposition on the pathogen which acts as an
__________
Opsonin
anaphylatoxins
major activity in all pathways includes release of C5a and C3a in the circulation which act
as ______________
anaphylatoxins
somatic recombination
________________:in primary gene rearrangements a random V, D and J segments are
brought together
somatic recombination
junctional diversity
________________: in primary gene rearrangement additional diversity added by TdT
junctional diversity
somatic hypermutation
________________: in secondary gene rearrangements, increases the recognition of the BCR
for its antigen
somatic hypermutation
class switching
________________: in secondary gene rearrangements, affects the effector function of the
BCR without modifying its ability to recognize the antigen
class switching
heavy; beta
The D segments are found in the __________ chain of the BCR and the __________ chain of
the TCR
heavy; beta
