Immunology PCB4233 exam 1 Questions And Answers With Verified Study Solutions Rated A+

Immunology PCB4233 exam 1

The early events of inflammation are characterized by all of the following except
_____________:

a. Vasodilation
b. Extravasation
c. Pain
d. Apoptosis
e. Chemotaxis - CORRECT ANSWER-d. Apoptosis

All of the following are involved in the alternative pathway of complement activation
except ________

a. C4
b. Factor B
c. Factor D
d. Properdin
e. C5 - CORRECT ANSWER-a. C4

A(n) _____________ is an inactive form of an enzyme that frequently participate in a
cascade of enzymatic reactions during complement activation.

a. Regulator of complement activation
b. Convertase
c. Zymogen
d. Complement control protein module
e. Opsonin - CORRECT ANSWER-c. Zymogen

Which of the following statements regarding TLR4 is false?

a. The ligand for TLR4 is LPS
b. TLR4 homo-dimerized upon binding with its ligand
c. TLR4 has an intracellular TIR domain
d. TLR4 is an example of a phagocytic receptor
e. The extracellular domain of TLR4 associate with MD2 - CORRECT ANSWER-d.
TLR4 is an example of a phagocytic receptor

An antimicrobial peptide that protects epithelial surfaces from pathogens is:

a. Glycoprotein
b. Defensin

,c. Proteoglycan
d. Lysozyme
e. Sebum - CORRECT ANSWER-b. Defensin

Which of the following describes chemokines?

a. Membrane receptors that detect the presence of cytokines
b. Soluble proteins that attract specific cells to an area
c. Transcription factors that induce the expression of genes involved in cell adhesion
d. Adhesion molecules that bind to the inside of blood vessels
e. PAMPs found on microorganisms particularly bacteria - CORRECT ANSWER-b.
Soluble proteins that attract specific cells to an area

Which of the following is the correct relationship? _________ on _________ recognize
_________ on _________.

a. PRRs : macrophages; PAMPs : neutrophils
b. PRRs : pathogen; PAMPs : macrophages
c. PAMPs : macrophages; PRRs : pathogens
d. PAMPs : neutrophils; PRRs : pathogen
e. PRRs : Macrophages; PAMPs : Pathogens - CORRECT ANSWER-e. PRRs :
Macrophages; PAMPs : Pathogens

Which of the following statement regarding the innate immune response is false:

a. Innate immune response is rapid
b. Innate immune response is based only on cells
c. Innate immune response lacks memory
d. Dendritic cells of the innate immune response will instruct the adaptive response
e. The receptors of the innate immune response recognize patterns found in pathogens
- CORRECT ANSWER-b. Innate immune response is based only on cells

The classical and lectin pathway C3 convertase is:

a. Masp-2
b. C4b2a
c. Factor D
d. Factor H
e. C3bBb - CORRECT ANSWER-b. C4b2a

1. C3b :

a. is chemotactic
b. is an anaphylatoxin
c. opsonizes bacteria
d. directly injures bacteria

,e. is the inactive form of C3 - CORRECT ANSWER-c. opsonizes bacteria

A term generally used to describe all white blood cells is:

a. Mast cell
b. myeloid progenitor
c. dendritic cell
d. leukocyte
e. polymorphonuclear (PMN) - CORRECT ANSWER-d. leukocyte

What is the name given to the earliest intracellular vesicle that contains material
opsonized by macrophages?

a. Opsonome
b. Membrane-attack complex
c. Phagosome
d. Lysosome
e. Specific granules - CORRECT ANSWER-c. Phagosome


Which of the following activities are most closely associated with natural killer (NK)
cells:

a. Production of TNF-alpha
b. Lysis of virally infected cells
c. Phagocytosis of bacteria
d. Destroying extracellular parasites
e. Induction of B-cell differentiation - CORRECT ANSWER-b. Lysis of virally infected
cells

Which of the following is NOT a postulate of the clonal selection theory regarding the T-
and B-cells:

a. only the lymphocyte whose receptor bind strongly to their ligand get activated
b. individual lymphocyte bears only one type of receptor with a unique specificity
c. each lymphocyte bears a B-cell receptor (BCR) and a T-cell receptor (TCR)
d. lymphocytes binding to self molecules are eliminated early on in development
e. activated lymphocytes will expand and all the daughter cells will have the same
specificity - CORRECT ANSWER-c. each lymphocyte bears a B-cell receptor (BCR)
and a T-cell receptor (TCR)

Which of the following acts as a serine protease that, with cofactors, cleaves and
inactivate C3b and C4b?
a. DAF (CD55)
b. Properdin
c. Factor H

, d. Factor I
e. MCP (CD46) - CORRECT ANSWER-d. Factor I

The first molecule of the complement binding covalently to the pathogen in the lectin
and the classical pathway is:

a. C3a
b. C4b
c. C2b
d. C5a
e. C9 - CORRECT ANSWER-b. C4b

The lectin pathway is initiated by:

a. Antibodies
b. Properdin
c. C1
d. MBL
e. MASP-2 - CORRECT ANSWER-d. MBL

Which of these statements is false regarding acute phase proteins

a. They are produced by the liver in response to Il-1/Il-6
b. Some of the acute phase proteins can be opsonin
c. They are cytokines produced by neutrophils
d. Some of the acute phase proteins can activate the complement
e. Mannose-binding lectin is an acute phase protein from the collectin family -
CORRECT ANSWER-c. They are cytokines produced by neutrophils

Which of the following statement is false about antibody

a. Antibodies can neutralize toxins
b. Antibodies are composed of two light and two heavy chains
c. Antibodies are produced by T-cells
d. Antibodies can opsonized pathogens
e. Antibodies can activate the complement pathway - CORRECT ANSWER-c.
Antibodies are produced by T-cells

Which of the following statement is fasle regarding type I IFNs:

a. induce cellular genes that destroy viral RNA
b. inhibit protein synthesis
c. induce lysis of extracellular bacteria
d. protect uninfected neighboring cells
e. activate NK cells - CORRECT ANSWER-c. induce lysis of extracellular bacteria