PCB4233 Exam 2 Questions And Answers With Verified Study Solutions Rated A+

Integrin- dependent T cell adhesion to antigen presenting cells increases substantially following TCR stimulation. This increased integrin- dependent adhesion is mediated in part by: - CORRECT ANSWER-LFA-1 conversion to a high affinity binding state Like TCR signaling, B cel receptor (BCR) signaling is initiated by kinase phosphorylating tyrosine resides in ITAM motids of BCR signaling subunit - CORRECT ANSWER-True Lymphocyte activation leads to robust proliferation and effector cell differentiation. The metabolic demands of these processes are met, in part, by upregulation of glycolytic enzymes and nutrient transporters on the activated cell membrane. A key intermediate in the signaling pathway leading to enhanced glucose metabolism following antigen receptor stimulation is: - CORRECT ANSWER-The phosphoinositide, (PIP3) What is the receptor on T cell surface that binds to B7 family molecules on a professional antigen-presenting cell? - CORRECT ANSWER-CD28 Thymus - CORRECT ANSWER-Which of the following statements is the best example of a primary lymphoid organ? V-J recombination occurs during which phase of a B-cell's development? - CORRECT ANSWER-Pre-B cell During B-cell development, pre-B receptors receive signals from self-antigens for the lymphocytes to survive and proliferate - CORRECT ANSWER-False Diacylglycerol (DAG) is one of two products generated when PLC-γ cleaves the membrane phospholipid, PIP2. This small lipid mediator remains associated with the plasma membrane and induce calcium entry into the cell - CORRECT ANSWER-False Which of the following alterations would result in increased signaling activity of Ras? - CORRECT ANSWER-Overexpression of GEFs When T cells express defective ER calcium sensor protein, they secrete very little IL-2 because activation of one of the following transcription is compromised. That transcription factor is: - CORRECT ANSWER-NFATIn negative selection, B-cells that interact weakly with self-antigens will either go anergic or enter a state of immunological ignorance. In both cases, the B cells are unresponsive to the antigens, so anergy and immunological ignorance are to names for the same phenomena - CORRECT ANSWER-False Where do immature B cells finish their maturation? - CORRECT ANSWER-Spleen An individual with normal B cells, but an absence of T cells might have a defect in: - CORRECT ANSWER-Thymic stromal cell In mice that lack both MHC class I and II in the thymus, T cell development will show: - CORRECT ANSWER-A block in T cell development at the CD4+ CD8+ double positive stage Which of the following options correctly describes a difference between the B cell receptors and T cell receptor? - CORRECT ANSWER-Expression of the B cell receptor stops further light chain rearrangement and enforces strict allelic exclusion, while expression of the T cell receptor does not restrict further rearrangement of the alpha chain until there is a signaling through peptide: MHC binding, resulting in many T cells that express two difference TCRalpha chain