PCB 4233 Quiz 3
Which of the following domain combinations constitutes the antigen-binding site of
immunoglobulins or T cell receptors? - CORRECT ANSWER-Valpha:Vbeta
On the cell surface of an antigen-presenting cell, what is the structure recognized by the
α:β T-cell receptor? - CORRECT ANSWER-Processed peptide antigen plus MHC
CD8 positive T cells recognize their antigen presented by which molecule? - CORRECT
ANSWER-MHC Class I
Using only random VDJ recombination, from 40 V, 25 D, and 6 J gene segments, what
are the number of possible variable regions of an antigen receptor molecule? -
CORRECT ANSWER-40 x 25 x 6 = 6000
B-cell receptor light chain gene locus lacks which of the following gene segments?
- Variable (V)
- Diversity (D)
- Joining (J)
- Constant (C) - CORRECT ANSWER-?
The basic immunoglobulin (Ig) unit is composed of - CORRECT ANSWER-Two identical
heavy chains and two identical light chains
A protein epitope formed as a result of three-dimensional folding of the protein, and
which is destroyed if the protein denatures, is called a _______ epitope. - CORRECT
ANSWER-conformational
(T/F) The antibody protein has two functional domains, one for antigen binding and a
second to confer specific effector functions. These two functional domains are encoded
by the antibody light chain and antibody heavy chain polypeptides, respectively. -
CORRECT ANSWER-False
Antibodies that bind with high affinity to some viral surface proteins require heavy chain
CDR3 loops of unusual length. Whereas the average human heavy chain CDR3 length
is ~15 amino acids, antibodies with VH CDR3 loops of >30 amino acids are readily
detected in the repertoire. Which enzyme is responsible for these unusually long CDR3
loops? - CORRECT ANSWER-Terminal deoxynucleotidyl transferase (TdT)
Hepatitis C is a virus that infects hepatocytes, which are non-immune cells of the liver.
Currently, patients with chronic Hepatitis C infections are treated with repeated
administration of type I interferon, predominantly interferon α. One aspect of this
treatment that might aid the patient's immune system in clearing this virus infection is:
Which of the following domain combinations constitutes the antigen-binding site of
immunoglobulins or T cell receptors? - CORRECT ANSWER-Valpha:Vbeta
On the cell surface of an antigen-presenting cell, what is the structure recognized by the
α:β T-cell receptor? - CORRECT ANSWER-Processed peptide antigen plus MHC
CD8 positive T cells recognize their antigen presented by which molecule? - CORRECT
ANSWER-MHC Class I
Using only random VDJ recombination, from 40 V, 25 D, and 6 J gene segments, what
are the number of possible variable regions of an antigen receptor molecule? -
CORRECT ANSWER-40 x 25 x 6 = 6000
B-cell receptor light chain gene locus lacks which of the following gene segments?
- Variable (V)
- Diversity (D)
- Joining (J)
- Constant (C) - CORRECT ANSWER-?
The basic immunoglobulin (Ig) unit is composed of - CORRECT ANSWER-Two identical
heavy chains and two identical light chains
A protein epitope formed as a result of three-dimensional folding of the protein, and
which is destroyed if the protein denatures, is called a _______ epitope. - CORRECT
ANSWER-conformational
(T/F) The antibody protein has two functional domains, one for antigen binding and a
second to confer specific effector functions. These two functional domains are encoded
by the antibody light chain and antibody heavy chain polypeptides, respectively. -
CORRECT ANSWER-False
Antibodies that bind with high affinity to some viral surface proteins require heavy chain
CDR3 loops of unusual length. Whereas the average human heavy chain CDR3 length
is ~15 amino acids, antibodies with VH CDR3 loops of >30 amino acids are readily
detected in the repertoire. Which enzyme is responsible for these unusually long CDR3
loops? - CORRECT ANSWER-Terminal deoxynucleotidyl transferase (TdT)
Hepatitis C is a virus that infects hepatocytes, which are non-immune cells of the liver.
Currently, patients with chronic Hepatitis C infections are treated with repeated
administration of type I interferon, predominantly interferon α. One aspect of this
treatment that might aid the patient's immune system in clearing this virus infection is:
