PCB4233 Lymphocyte Activation
Bonds formed between the T cell and a dendritic cell are relatively weak. Which of the
following help to strengthen this association so that a T cell can see which antigen is
being presented by a dendritic cell?
a. CD28/LFA-5
b. CD 28
c. ICAM-1/LFA-1
d. IL-2R
e. Pattern-recognition molecules - CORRECT ANSWER-c. ICAM-1/LFA-1
With regard to the type of B-cell response generated, carbohydrate antigens CANNOT
provoke which of the following responses?
a. TI-1
b. TI-2
c. Thymus-Dependent
d. Both A and B
e. None of the above - CORRECT ANSWER-c. Thymus-Dependent
Activated TH cells signal to B cells to initiate their activation program via which of the
following?
a. CD40L on the T cell to CD40 on the B cell
b. CD28 on the T cell to CD40L on the B cell
c. FasL on the T cell to Fas on the B cell
d. Fas on the T cell to FasL on the B cell
e. Notch ligand on the B cell to notch-1 on the T cell - CORRECT ANSWER-a. CD40L
on the T cell to CD40 on the B cell
Which of the following does NOT occur shortly following oligomerization of the BCR
upon antigen binding?
a. Movement of the BCR complex into areas of the membrane called "lipid rafts"
b. Positioning of Igα and Igβ to allow for phosphorylation of their ITAM motifs
c. Positioning of CD3 to allow for phosphorylation if its ITAM motifs
d. Formation of microcluster of BCR complex
e. All of the above occur. - CORRECT ANSWER-c. Positioning of CD3 to allow for
phosphorylation if its ITAM motifs
7. _____ is a second messenger in the T-cell signaling pathway leading to the activation
of NFAT.
, a. MAPK
b. NF-κB
c. Inositol triphosphate
d. Fos
e. Ras. - CORRECT ANSWER-c. Inositol triphosphate
The T-cell ligand binding B7 on APC is:
a. CD2
b. LFA-1
c. VCAM-1
d. CD28
e. ICAM-1 - CORRECT ANSWER-d. CD28
What event initiates an adaptive immune response?
a. The interaction of a B cell with a TH cell
b. The expression of cytokines CD4 or CD8
c. The production of MHC class I or II molecules
d. The interaction of a naïve T cell with an antigen-presenting cell
e. The phagocytosis of a pathogen by a macrophage - CORRECT ANSWER-d. The
interaction of a naïve T cell with an antigen-presenting cell
A naïve T cell refers to a T cell that:
a. does not express CD4+ or CD8+.
b. has not left the bone marrow.
c. has not yet encountered an antigen.
d. is not mature.
e. resides in the thymus. - CORRECT ANSWER-c. has not yet encountered an antigen.
Which of the following event occurs earliest in T-cell signaling:
a. activation of phospholipase C
b. activation of protein kinase C
c. production of inositol triphosphate
d. activation of protein tyrosine kinase
e. mobilization of intracellular calcium - CORRECT ANSWER-d. activation of protein
tyrosine kinase
T-cell help for antibody production:
a. Depends on T-cell recognition of native antigen bound to B-cell surface Ig.
Bonds formed between the T cell and a dendritic cell are relatively weak. Which of the
following help to strengthen this association so that a T cell can see which antigen is
being presented by a dendritic cell?
a. CD28/LFA-5
b. CD 28
c. ICAM-1/LFA-1
d. IL-2R
e. Pattern-recognition molecules - CORRECT ANSWER-c. ICAM-1/LFA-1
With regard to the type of B-cell response generated, carbohydrate antigens CANNOT
provoke which of the following responses?
a. TI-1
b. TI-2
c. Thymus-Dependent
d. Both A and B
e. None of the above - CORRECT ANSWER-c. Thymus-Dependent
Activated TH cells signal to B cells to initiate their activation program via which of the
following?
a. CD40L on the T cell to CD40 on the B cell
b. CD28 on the T cell to CD40L on the B cell
c. FasL on the T cell to Fas on the B cell
d. Fas on the T cell to FasL on the B cell
e. Notch ligand on the B cell to notch-1 on the T cell - CORRECT ANSWER-a. CD40L
on the T cell to CD40 on the B cell
Which of the following does NOT occur shortly following oligomerization of the BCR
upon antigen binding?
a. Movement of the BCR complex into areas of the membrane called "lipid rafts"
b. Positioning of Igα and Igβ to allow for phosphorylation of their ITAM motifs
c. Positioning of CD3 to allow for phosphorylation if its ITAM motifs
d. Formation of microcluster of BCR complex
e. All of the above occur. - CORRECT ANSWER-c. Positioning of CD3 to allow for
phosphorylation if its ITAM motifs
7. _____ is a second messenger in the T-cell signaling pathway leading to the activation
of NFAT.
, a. MAPK
b. NF-κB
c. Inositol triphosphate
d. Fos
e. Ras. - CORRECT ANSWER-c. Inositol triphosphate
The T-cell ligand binding B7 on APC is:
a. CD2
b. LFA-1
c. VCAM-1
d. CD28
e. ICAM-1 - CORRECT ANSWER-d. CD28
What event initiates an adaptive immune response?
a. The interaction of a B cell with a TH cell
b. The expression of cytokines CD4 or CD8
c. The production of MHC class I or II molecules
d. The interaction of a naïve T cell with an antigen-presenting cell
e. The phagocytosis of a pathogen by a macrophage - CORRECT ANSWER-d. The
interaction of a naïve T cell with an antigen-presenting cell
A naïve T cell refers to a T cell that:
a. does not express CD4+ or CD8+.
b. has not left the bone marrow.
c. has not yet encountered an antigen.
d. is not mature.
e. resides in the thymus. - CORRECT ANSWER-c. has not yet encountered an antigen.
Which of the following event occurs earliest in T-cell signaling:
a. activation of phospholipase C
b. activation of protein kinase C
c. production of inositol triphosphate
d. activation of protein tyrosine kinase
e. mobilization of intracellular calcium - CORRECT ANSWER-d. activation of protein
tyrosine kinase
T-cell help for antibody production:
a. Depends on T-cell recognition of native antigen bound to B-cell surface Ig.
