PCB 3233 Exam-2-si-immuno-key-1
university of central Florida Questions &
Answers with complete
Which type of immune response should one expect to see after 4 hours of pathogen contact?
(Ranges between 4 hours and 4 days).
A. Innate immune response
B. Immediate innate immune response
C. Induced innate immune response
D. A&C
E. A, B, & C
2) Which of the following might you expect to see as a result of the innate immune response?
A. Plasma cells secreting antibodies
B. Inflammation
C. Leukocytes moving to site of infection
D. Soluble molecules being made/secreted into the blood and site of infection
E. A, B, & C
F. B, C, & D
3) True or False: Macrophages recognize the surface of infected human cells, while NK cells
recognize the surface of bacterial cells.
4) C3b is the ligand for ; while iC3b is the ligand for
A. CR1 ; CR2 + CR4
B. CR2 + CR4 ; CR1
C. CR1 ; CR3 + CR4… CR2 binds to C3d
D. CR3 + CR4 ; CR1
5) True or False: Complement Receptors 3 and 4 recognize iC3b, as well as lipoteichoic acids.
NOT lipoteichoic, instead lipopolysaccharide (LPS)… found in gram negatives
6) Scavenger receptors show a preference for what type of ligands?
A. Positively charged molecules
B. Negatively charged molecules
C. Gram negative bacteria
D. Gram positive bacteria
E. A, B, & C
, F. B, C, & D
7) Which type of receptor leads to a signaling cascade (or pathway)?
A. Mannose receptors
B. Complement receptors
C. Toll-like receptors… DON’T lead to phagocytosis… instead, they lead to cytokine
creation/secretion
D. Scavenger receptors
8) True or False: LPS directly binds to TLR-4. NEED LBP, CD14, and MD2 to make that
connection to TLR-4.
9) Match the following receptors with their characteristic ligand.
A. TLR-3 i. Single-stranded viral RNA
B. TLR-4 ii. Double-stranded viral RNA
C. TLR-5 iii. LPS
D. TLR-7 iv. Flagellin
10) True or False: In the cytokine creation/secretion pathway, NFB goes from the nucleus to the
cytoplasm to carry out transcription/translation of cytokine genes. NFkB goes from cytoplasm to
the nucleus,
11) What is the main role of the cytokine called “CXCL8”?
A. Make blood vessels become more permeable
B. Recruit and activate NK cells
C. Induce fat and muscle cells to metabolize
D. Recruit neutrophils to site of infection… ALL chemokines are cytokines, NOT ALL
cytokines are chemokines… chemokines create a gradient to attract leukocytes to site of
infection… CCL-2 recruits monocytes to the site of infection
12) What are some characteristics of TNF-?
A. Prevents spread of infection
B. Causes blood in venules to clot
C. Reduces permeability in blood vessels
D. A&B
E. A, B, & C
university of central Florida Questions &
Answers with complete
Which type of immune response should one expect to see after 4 hours of pathogen contact?
(Ranges between 4 hours and 4 days).
A. Innate immune response
B. Immediate innate immune response
C. Induced innate immune response
D. A&C
E. A, B, & C
2) Which of the following might you expect to see as a result of the innate immune response?
A. Plasma cells secreting antibodies
B. Inflammation
C. Leukocytes moving to site of infection
D. Soluble molecules being made/secreted into the blood and site of infection
E. A, B, & C
F. B, C, & D
3) True or False: Macrophages recognize the surface of infected human cells, while NK cells
recognize the surface of bacterial cells.
4) C3b is the ligand for ; while iC3b is the ligand for
A. CR1 ; CR2 + CR4
B. CR2 + CR4 ; CR1
C. CR1 ; CR3 + CR4… CR2 binds to C3d
D. CR3 + CR4 ; CR1
5) True or False: Complement Receptors 3 and 4 recognize iC3b, as well as lipoteichoic acids.
NOT lipoteichoic, instead lipopolysaccharide (LPS)… found in gram negatives
6) Scavenger receptors show a preference for what type of ligands?
A. Positively charged molecules
B. Negatively charged molecules
C. Gram negative bacteria
D. Gram positive bacteria
E. A, B, & C
, F. B, C, & D
7) Which type of receptor leads to a signaling cascade (or pathway)?
A. Mannose receptors
B. Complement receptors
C. Toll-like receptors… DON’T lead to phagocytosis… instead, they lead to cytokine
creation/secretion
D. Scavenger receptors
8) True or False: LPS directly binds to TLR-4. NEED LBP, CD14, and MD2 to make that
connection to TLR-4.
9) Match the following receptors with their characteristic ligand.
A. TLR-3 i. Single-stranded viral RNA
B. TLR-4 ii. Double-stranded viral RNA
C. TLR-5 iii. LPS
D. TLR-7 iv. Flagellin
10) True or False: In the cytokine creation/secretion pathway, NFB goes from the nucleus to the
cytoplasm to carry out transcription/translation of cytokine genes. NFkB goes from cytoplasm to
the nucleus,
11) What is the main role of the cytokine called “CXCL8”?
A. Make blood vessels become more permeable
B. Recruit and activate NK cells
C. Induce fat and muscle cells to metabolize
D. Recruit neutrophils to site of infection… ALL chemokines are cytokines, NOT ALL
cytokines are chemokines… chemokines create a gradient to attract leukocytes to site of
infection… CCL-2 recruits monocytes to the site of infection
12) What are some characteristics of TNF-?
A. Prevents spread of infection
B. Causes blood in venules to clot
C. Reduces permeability in blood vessels
D. A&B
E. A, B, & C
