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150 NCLEX Practice Questions & Rationales (2026/2027) - Comprehensive Nursing Exam Prep

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Ace your nursing exams with this comprehensive bank of 150 NCLEX-style practice questions updated for 2026/2027. This resource is designed to mirror the diversity of the actual board exam, providing questions, answers, and detailed rationales to ensure you understand the "why" behind every correct choice . What’s Inside: Fundamentals of Nursing: Master core concepts like patient identification safety, hand hygiene, pressure ulcer prevention, and proper positioning (Fowler's) for dyspnea . Pharmacology: Critical review of high-yield medications including Insulin (hypoglycemia management), Furosemide (potassium monitoring), Warfarin (Vitamin K interactions), and Naloxone . Medical-Surgical Nursing: In-depth coverage of Myocardial Infarction, COPD oxygenation, Electrolyte Imbalances (Hypocalcemia, Hyperkalemia), and Hypertension (DASH diet) . Maternal & Newborn Nursing: Essential knowledge on stages of labor, Preeclampsia signs, APGAR scoring, and neonatal vital signs . Pediatric Nursing: Focus on respiratory distress signs, vaccine schedules (MMR), and SIDS prevention (supine sleep position) . Psychiatric Nursing: Key concepts in therapeutic communication, suicide safety, mania symptoms, and medications like Sertraline and Lithium . Safety & Infection Control: Detailed breakdown of Standard, Contact, and Airborne precautions (TB, MRSA, Influenza) and the RACE fire safety protocol . Mixed Critical Thinking Questions: Rapid-fire review of ABGs, GFR, stroke assessment (FAST), and emergency interventions for anaphylaxis and shock . Whether you are preparing for your HESI, ATI, or the NCLEX-RN/PN, this 42-page guide provides the rigorous practice needed to build clinical judgment and exam stamina .

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NCLEX Practice Questions (1–150) With Answers and
Rationales 2026/2027




Fundamentals of Nursing

1. A nurse is preparing to administer medication but notes the
patient’s identification band is missing. What should the nurse do
first?

A. Ask the patient to state their name
B. Administer the medication anyway
C. Notify the physician
D. Obtain a new identification band

Answer: D

Rationale:
Patient identification is essential before medication administration. A
new ID band must be applied before giving medication to ensure safety.



2. Which action demonstrates proper hand hygiene?

A. Washing hands for 5 seconds
B. Using alcohol sanitizer on visibly soiled hands
C. Washing hands for at least 20 seconds
D. Rinsing hands without soap

Answer: C

,2|Page


Rationale:
Effective handwashing requires soap and water for at least 20 seconds,
especially when hands are visibly dirty.



3. A patient is at risk for pressure ulcers. Which intervention is
priority?

A. Encourage high fluid intake
B. Turn patient every 2 hours
C. Apply lotion daily
D. Provide high-fiber diet

Answer: B

Rationale:
Frequent repositioning prevents prolonged pressure on skin and reduces
risk of pressure injuries.



4. Which position is best for a patient with dyspnea?

A. Supine
B. Fowler’s
C. Trendelenburg
D. Sims

Answer: B

Rationale:
Fowler’s position improves lung expansion and oxygenation.



5. Which finding indicates dehydration?

,3|Page


A. Moist mucous membranes
B. Decreased urine specific gravity
C. Dry skin and tachycardia
D. Bradycardia

Answer: C

Rationale:
Dehydration signs include dry skin, tachycardia, decreased urine output,
and hypotension.



Pharmacology

6. A patient taking insulin shows confusion and sweating. What is
the nurse’s first action?

A. Administer insulin
B. Give orange juice
C. Call physician
D. Check temperature

Answer: B

Rationale:
Symptoms indicate hypoglycemia. Immediate administration of fast-
acting carbohydrates is required.



7. Which medication requires monitoring potassium levels?

A. Furosemide
B. Amoxicillin
C. Acetaminophen
D. Ibuprofen

, 4|Page


Answer: A

Rationale:
Loop diuretics such as furosemide cause potassium loss leading to
hypokalemia.



8. A patient taking warfarin should avoid which food?

A. Bananas
B. Spinach
C. Rice
D. Chicken

Answer: B

Rationale:
Spinach contains vitamin K which reduces warfarin effectiveness.



9. What is the antidote for opioid overdose?

A. Naloxone
B. Atropine
C. Flumazenil
D. Epinephrine

Answer: A

Rationale:
Naloxone reverses opioid effects by blocking opioid receptors.



10. Which adverse effect is common with ACE inhibitors?

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