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, Terms in this set (126)
What is the monoamine hypothesis of depression? It theorizes that depression is caused by a deficiency in monoamine
neurotransmission, while mania is due to an excess.
What is a key prescribing consideration for Antidepressants should not be given as monotherapy; they must be
antidepressants in bipolar disorder? combined with a mood stabilizer to avoid inducing mania.
What should be monitored when prescribing SNRIs Infant irritability.
to breastfeeding patients?
What factors should be considered when prescribing Client preference, prior treatment response, anticipated adverse effects,
antidepressants? comorbidities, half-life, interactions, and cost.
What should be done if the initial antidepressant First, increase the dose; if that fails, switch to a different drug in the same
does not work? class, then try a drug in a different class, and possibly add a second
medication.
What is the recommended dose adjustment for older They should receive half the usual dose.
patients taking citalopram and escitalopram?
Which SSRI has the least CYP interactions? Escitalopram (Lexapro).
Which SSRI is considered good for forgetful Fluoxetine, due to its 2-3 day half-life.
patients?
What is the longest-acting antidepressant? Fluoxetine, with a half-life of 1-2 weeks.
What is discontinuation syndrome and which Discontinuation syndrome occurs when stopping an antidepressant, and
medication is more likely to cause it? paroxetine is more likely to cause it.
Which antidepressant is safe during nursing and Sertraline.
pregnancy?
What is serotonin syndrome? A condition that occurs when two serotonergic drugs are used together,
leading to symptoms such as mental status changes, autonomic instability,
neuromuscular symptoms, seizures, and gastrointestinal symptoms.
What is the treatment for serotonin syndrome? Stop the medication, provide supportive care, and use benzodiazepines.
What is the black box warning for MAOIs? They carry a warning for suicidal ideation in children, adolescents, and
young adults.
What is the half-life of MAOIs? 2-4 hours.
What is the black box warning for SSRIs? They carry a warning for suicidal tendencies.
What are MAOIs and what do they inhibit? MAOIs (monoamine oxidase inhibitors) are antidepressants that inhibit the
enzyme that deactivates dopamine, norepinephrine, and serotonin.
What can happen if MAOIs are taken with tyramine- They can cause a hypertensive crisis.
containing foods?
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N
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Students
also
studied
, Terms in this set (126)
What is the monoamine hypothesis of depression? It theorizes that depression is caused by a deficiency in monoamine
neurotransmission, while mania is due to an excess.
What is a key prescribing consideration for Antidepressants should not be given as monotherapy; they must be
antidepressants in bipolar disorder? combined with a mood stabilizer to avoid inducing mania.
What should be monitored when prescribing SNRIs Infant irritability.
to breastfeeding patients?
What factors should be considered when prescribing Client preference, prior treatment response, anticipated adverse effects,
antidepressants? comorbidities, half-life, interactions, and cost.
What should be done if the initial antidepressant First, increase the dose; if that fails, switch to a different drug in the same
does not work? class, then try a drug in a different class, and possibly add a second
medication.
What is the recommended dose adjustment for older They should receive half the usual dose.
patients taking citalopram and escitalopram?
Which SSRI has the least CYP interactions? Escitalopram (Lexapro).
Which SSRI is considered good for forgetful Fluoxetine, due to its 2-3 day half-life.
patients?
What is the longest-acting antidepressant? Fluoxetine, with a half-life of 1-2 weeks.
What is discontinuation syndrome and which Discontinuation syndrome occurs when stopping an antidepressant, and
medication is more likely to cause it? paroxetine is more likely to cause it.
Which antidepressant is safe during nursing and Sertraline.
pregnancy?
What is serotonin syndrome? A condition that occurs when two serotonergic drugs are used together,
leading to symptoms such as mental status changes, autonomic instability,
neuromuscular symptoms, seizures, and gastrointestinal symptoms.
What is the treatment for serotonin syndrome? Stop the medication, provide supportive care, and use benzodiazepines.
What is the black box warning for MAOIs? They carry a warning for suicidal ideation in children, adolescents, and
young adults.
What is the half-life of MAOIs? 2-4 hours.
What is the black box warning for SSRIs? They carry a warning for suicidal tendencies.
What are MAOIs and what do they inhibit? MAOIs (monoamine oxidase inhibitors) are antidepressants that inhibit the
enzyme that deactivates dopamine, norepinephrine, and serotonin.
What can happen if MAOIs are taken with tyramine- They can cause a hypertensive crisis.
containing foods?
