PSIO 431 IMMUNO UAZ
Which class of antibody has a valence of 10?
IgE
IgM
IgG
IgA - ✔️✔️IgM
My preparation of IgG anti-Streptococcus, which used to agglutinate the bacteria
very effectively, has been tampered with by my evil graduate student! Now I find
that what's in the tube binds specifically to Streptococcus, but there is no
agglutination! I think that what I have now is:
Fc
F(ab)2
Fab
Aged complement - ✔️✔️Fab
Lymphocytes are made to fit an antigen
Question 5 options:
True
False - ✔️✔️False
Scientists are developing a new herpes vaccine. They should focus on part of the
virus that is a good ___________.
Question 6 options:
Antigen
Mitogen
Epitope
Immunogen - ✔️✔️Antigen
Although _____is the most effective at activating complement, ___________is the
most abundant serum immunoglobulin.
Question 7 options:
IgG; IgM
IgA; IgM
IgM; IgG
IgM; IgE - ✔️✔️IgM; IgG
I isolated a single plasma cell that was secreting IgG, and sequenced a single H
chain (new technology allows this with 100% accuracy). At the position in this
image shown by the arrow, on the Fc part of the H chain, I found the amino acid
serine. That was a surprise, as almost all humans have alanine at that position. I
asked an expert in my department what the amino acid in the exact same position
,on the other H chain in this particular molecule would be. What was the expert
response?
There's no way to know based on the information above
Because of allotypic exclusion, it will be serine
Because of allotypic exclusion, it will be alanine
Statistically, it's much more likely to be alanine - ✔️✔️Because of allotypic
exclusion, it will be serine
Which of the following is the most sensitive test of antibody-antigen binding?
Question 9 options:
Precipitation
Hapten test
Lattice test
Agglutination - ✔️✔️Agglutination
A new species of rodent is found on a tiny island. Genetic analysis shows that it
is fully inbred. When its immunoglobulin genes are examined, its H chain region
shows 4 V, 3 D and 5 J segments. It has no lambda light chains, only kappa; they
have 5 V, and 3 J (there are no D regions in light chains). So, ignoring any
somatic mechanisms except V(D)J recombination, the germ line alone predicts
that this animal could make how many antibodies?
40
10,000
75
900 - ✔️✔️900
Why is the quantity of IgE so low in the serum?
It binds immediately to Fc receptors on Mast cells
It is mostly found floating in the tissue fluids
It moves into the mucus membranes
It binds immediately to Fc receptors on neutrophils - ✔️✔️It binds immediately to
Fc receptors on Mast cells
Dr. Jenner showed that vaccination with Cowpox protected people from
Smallpox. What is that called?
Innoculation
Cross-Reaction
Clonal Selection
Somatic Hypermutation - ✔️✔️Cross-Reaction
Got a 9/10 on these next 10 problems - ✔️✔️
A fetus makes both IgM and IgG antibodies
Question 1 options:
True
, False - ✔️✔️False
I have a sample of cells from the bone marrow. What would be the first "sign" that
the cell I'm looking at is going to be a B cell?
Question 2 options:
cytoplasmic delta chain
cytoplasmic mu chain
surface IgM
surface IgD - ✔️✔️cytoplasmic mu chain
At birth an infant has 200 units of IgG antibody against rubella per ML in his
blood. He is not exposed to rubella. At 9 weeks of age, what should the
concentration be?
Question 3 options:
25 units
50 units
0 units, as he has not been exposed to the virus
100 units - ✔️✔️25 units
Select the immunoglobulin class to which the statement best applies: (answers
can be used more than once) - ✔️✔️Composed of 21 polypeptide chains IgM
The class of the antigen receptor found on the surface of mature B cells but NOT
on immature B cells IgD
The class whose Fc portion binds to mast cells IgE
Clonal selection occurs in B and T lymphocytes
Question 5 options:
True
False - ✔️✔️True
A routine sample of a newborn baby's blood is sent to the lab to be tested for
antibody to cytomegalovirus, which can cause serious developmental
abnormalities in an infected fetus. The ward clerk says the report has been called
in as "positive" (there are antibodies that bind cytomegalovirus). You think:
Question 7 options:
If it's IgM, I'll be worried
If it's IgG and IgM,I won't worry
If it's IgG, I'll suspect a lab error
If it's IgG, I'll be worried - ✔️✔️If it's IgG and IgM,I won't worry
I want to create a test to tell T cells from other cells in my dish. Which of the
following markers would NOT be useful?
Question 6 options:
TCR
Which class of antibody has a valence of 10?
IgE
IgM
IgG
IgA - ✔️✔️IgM
My preparation of IgG anti-Streptococcus, which used to agglutinate the bacteria
very effectively, has been tampered with by my evil graduate student! Now I find
that what's in the tube binds specifically to Streptococcus, but there is no
agglutination! I think that what I have now is:
Fc
F(ab)2
Fab
Aged complement - ✔️✔️Fab
Lymphocytes are made to fit an antigen
Question 5 options:
True
False - ✔️✔️False
Scientists are developing a new herpes vaccine. They should focus on part of the
virus that is a good ___________.
Question 6 options:
Antigen
Mitogen
Epitope
Immunogen - ✔️✔️Antigen
Although _____is the most effective at activating complement, ___________is the
most abundant serum immunoglobulin.
Question 7 options:
IgG; IgM
IgA; IgM
IgM; IgG
IgM; IgE - ✔️✔️IgM; IgG
I isolated a single plasma cell that was secreting IgG, and sequenced a single H
chain (new technology allows this with 100% accuracy). At the position in this
image shown by the arrow, on the Fc part of the H chain, I found the amino acid
serine. That was a surprise, as almost all humans have alanine at that position. I
asked an expert in my department what the amino acid in the exact same position
,on the other H chain in this particular molecule would be. What was the expert
response?
There's no way to know based on the information above
Because of allotypic exclusion, it will be serine
Because of allotypic exclusion, it will be alanine
Statistically, it's much more likely to be alanine - ✔️✔️Because of allotypic
exclusion, it will be serine
Which of the following is the most sensitive test of antibody-antigen binding?
Question 9 options:
Precipitation
Hapten test
Lattice test
Agglutination - ✔️✔️Agglutination
A new species of rodent is found on a tiny island. Genetic analysis shows that it
is fully inbred. When its immunoglobulin genes are examined, its H chain region
shows 4 V, 3 D and 5 J segments. It has no lambda light chains, only kappa; they
have 5 V, and 3 J (there are no D regions in light chains). So, ignoring any
somatic mechanisms except V(D)J recombination, the germ line alone predicts
that this animal could make how many antibodies?
40
10,000
75
900 - ✔️✔️900
Why is the quantity of IgE so low in the serum?
It binds immediately to Fc receptors on Mast cells
It is mostly found floating in the tissue fluids
It moves into the mucus membranes
It binds immediately to Fc receptors on neutrophils - ✔️✔️It binds immediately to
Fc receptors on Mast cells
Dr. Jenner showed that vaccination with Cowpox protected people from
Smallpox. What is that called?
Innoculation
Cross-Reaction
Clonal Selection
Somatic Hypermutation - ✔️✔️Cross-Reaction
Got a 9/10 on these next 10 problems - ✔️✔️
A fetus makes both IgM and IgG antibodies
Question 1 options:
True
, False - ✔️✔️False
I have a sample of cells from the bone marrow. What would be the first "sign" that
the cell I'm looking at is going to be a B cell?
Question 2 options:
cytoplasmic delta chain
cytoplasmic mu chain
surface IgM
surface IgD - ✔️✔️cytoplasmic mu chain
At birth an infant has 200 units of IgG antibody against rubella per ML in his
blood. He is not exposed to rubella. At 9 weeks of age, what should the
concentration be?
Question 3 options:
25 units
50 units
0 units, as he has not been exposed to the virus
100 units - ✔️✔️25 units
Select the immunoglobulin class to which the statement best applies: (answers
can be used more than once) - ✔️✔️Composed of 21 polypeptide chains IgM
The class of the antigen receptor found on the surface of mature B cells but NOT
on immature B cells IgD
The class whose Fc portion binds to mast cells IgE
Clonal selection occurs in B and T lymphocytes
Question 5 options:
True
False - ✔️✔️True
A routine sample of a newborn baby's blood is sent to the lab to be tested for
antibody to cytomegalovirus, which can cause serious developmental
abnormalities in an infected fetus. The ward clerk says the report has been called
in as "positive" (there are antibodies that bind cytomegalovirus). You think:
Question 7 options:
If it's IgM, I'll be worried
If it's IgG and IgM,I won't worry
If it's IgG, I'll suspect a lab error
If it's IgG, I'll be worried - ✔️✔️If it's IgG and IgM,I won't worry
I want to create a test to tell T cells from other cells in my dish. Which of the
following markers would NOT be useful?
Question 6 options:
TCR
