NURS 5315 UTA Exam 2
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COX2 - correct answer Prostaglandin of arachidonic pathway. Responsible for pain, fever, renal
protection, tissue repair, reproduction development.
COX2 inhibitors- clinical implications - correct answer Protect gastric mucosa- prevent ulcers
and bleeding. Removed from market r/t cardiac events except for Celebrex. Can impair renal
function , monitor labs.
Arachidonic pathway purpose - correct answer Synthesis of prostaglandins
Non-selective NSAIDS - correct answer Inhibit COX1 and COX2, risk for gastric ulceration, GI
bleeds, edema, renal impairment
ASA - correct answer Blocks COX1 and COX2, also inhibits Thromboxane A2 and prostaglandins
Corticosteroids - correct answer Inhibit phospholipase A2, preventing formation of
prostaglandins, thromboxane A2, prostacyclin, and leukotrines
Thromboxane - correct answer Vasoconstriction, platelet aggregation
Prostacyclin - correct answer Vasodilation, platelet aggregation (most effective one)
,Type 1 hypersensitivity - correct answer E. Immediate response to allergen, food, meds, pollen,
asthma, allergic reactions
P. IgE binds with antigen at 1st exposure. Antigen binds with this complex at 2nd exposure.
Inflammatory cascade initiates.
C.M. Urticaria, rhinitis, conjunctivitis, angioedema, anaphylaxis
Atopic disorders - correct answer Genetic Type 1 hypersensitivity, asthma, hay fever, eczema,
urticaria
Type 2 hypersensitivity - correct answer E. Antibodies directed against fixed antigens on the
plasma membrane of cells
C.M. Varies depending on alloimmune or autoimmune
Alloimmunity and example of hypersensitivity - correct answer When an individuals immune
system reacts against antigens on the tissues of other members of the same species
Blood transfusions- causes clumping and lysis of RBC- fever, nausea, chills, low back pain, dark
urine, hives, itching, SOB
Rh incompatibility- hemolytic disease of newborn with jaundice, give Rhogam within 72 hours
of birth (Rh- mother with Rh+ child)
Autoimmunity and example of hypersensitivity - correct answer A breakdown of tolerance in
which the bodies immune system begins to recognize self-antigens as foreign.
Graves Disease- autoantibodies form against thyroid cells- bind to thyroid cells and mimic action
of TSH, increases secretion of thyroxine
Myasthenia Gravis- autoantibodies against acetylcholine bind to the post synaptic receptors and
inhibit synaptic transmission of acetylcholine. Leads to muscle weakness and paralysis (mind to
ground)
, Guillain-Barre' syndrome- antibodies bind with myelin sheath of the peripheral nervous system,
triggering the immune response. Causes demyelination of the peripheral nerves and a rapidly
progressive, ascending paralysis (ground to brain)
Type III hypersensitivity - correct answer Widespread immune and inflammatory response not
specified for any cell or tissue. SLE, RA
Antibodies are formed against and bind to circulating antigens, antigen-antibody complex
deposits in vessel walls or tissue. Causes cellular and tissue damage. IgG and IgM response,
spread via circulation- not specific to a cell or tissue- widespread damage.
Type IV hypersensitivity - correct answer T-cell lymphocyte mediated reaction that does not
require antibody activation. Delayed response- 24-72 hours.
Contact dermatitis- poison ivy, topical drugs, chemicals such as nickel or formaldehyde. Antigens
too small to cause a reaction bind to proteins, response includes rash, red bumps, itching, and
blisters.
Reactive tuberculin test- PPD cause and induration in 24-72 if person was previously exposed to
tuberculin antigen
Solid organ transplant rejection- 11-14 days after 1st exposure, 5-6 days after 2nd exposure,
results in mononuclear infiltration, decreased circulation, and tissue necrosis.
Systemic Lupus Erythematosus - correct answer E. Primarily women aged 20-40, Type III
hypersensitivity. Antibodies are formed against DNA
Genetic, leads to tissue damage. Exacerbated by infections, UV light, estrogen, meds, stress
Diagnosed by serum ANA
C.M. Butterfly rash (cheeks), photosensitivity, nonerosive arthritis of at least 2 peripheral joints,
inflammation of serous sacs, proteinuria, seizures, anemia, leukopenia, thrombocytopenia
Rheumatoid Arthritis - correct answer E. Primarily women 30-50, systemic autoimmune disease
Progressive, irreversible leads to deformity and disability
Tx includes PT, NSAIDS, corticosteroids
LATEST QUESTIONS AND
VERIFIED ANSWERS 100%
GUARANTEED PASS
COX2 - correct answer Prostaglandin of arachidonic pathway. Responsible for pain, fever, renal
protection, tissue repair, reproduction development.
COX2 inhibitors- clinical implications - correct answer Protect gastric mucosa- prevent ulcers
and bleeding. Removed from market r/t cardiac events except for Celebrex. Can impair renal
function , monitor labs.
Arachidonic pathway purpose - correct answer Synthesis of prostaglandins
Non-selective NSAIDS - correct answer Inhibit COX1 and COX2, risk for gastric ulceration, GI
bleeds, edema, renal impairment
ASA - correct answer Blocks COX1 and COX2, also inhibits Thromboxane A2 and prostaglandins
Corticosteroids - correct answer Inhibit phospholipase A2, preventing formation of
prostaglandins, thromboxane A2, prostacyclin, and leukotrines
Thromboxane - correct answer Vasoconstriction, platelet aggregation
Prostacyclin - correct answer Vasodilation, platelet aggregation (most effective one)
,Type 1 hypersensitivity - correct answer E. Immediate response to allergen, food, meds, pollen,
asthma, allergic reactions
P. IgE binds with antigen at 1st exposure. Antigen binds with this complex at 2nd exposure.
Inflammatory cascade initiates.
C.M. Urticaria, rhinitis, conjunctivitis, angioedema, anaphylaxis
Atopic disorders - correct answer Genetic Type 1 hypersensitivity, asthma, hay fever, eczema,
urticaria
Type 2 hypersensitivity - correct answer E. Antibodies directed against fixed antigens on the
plasma membrane of cells
C.M. Varies depending on alloimmune or autoimmune
Alloimmunity and example of hypersensitivity - correct answer When an individuals immune
system reacts against antigens on the tissues of other members of the same species
Blood transfusions- causes clumping and lysis of RBC- fever, nausea, chills, low back pain, dark
urine, hives, itching, SOB
Rh incompatibility- hemolytic disease of newborn with jaundice, give Rhogam within 72 hours
of birth (Rh- mother with Rh+ child)
Autoimmunity and example of hypersensitivity - correct answer A breakdown of tolerance in
which the bodies immune system begins to recognize self-antigens as foreign.
Graves Disease- autoantibodies form against thyroid cells- bind to thyroid cells and mimic action
of TSH, increases secretion of thyroxine
Myasthenia Gravis- autoantibodies against acetylcholine bind to the post synaptic receptors and
inhibit synaptic transmission of acetylcholine. Leads to muscle weakness and paralysis (mind to
ground)
, Guillain-Barre' syndrome- antibodies bind with myelin sheath of the peripheral nervous system,
triggering the immune response. Causes demyelination of the peripheral nerves and a rapidly
progressive, ascending paralysis (ground to brain)
Type III hypersensitivity - correct answer Widespread immune and inflammatory response not
specified for any cell or tissue. SLE, RA
Antibodies are formed against and bind to circulating antigens, antigen-antibody complex
deposits in vessel walls or tissue. Causes cellular and tissue damage. IgG and IgM response,
spread via circulation- not specific to a cell or tissue- widespread damage.
Type IV hypersensitivity - correct answer T-cell lymphocyte mediated reaction that does not
require antibody activation. Delayed response- 24-72 hours.
Contact dermatitis- poison ivy, topical drugs, chemicals such as nickel or formaldehyde. Antigens
too small to cause a reaction bind to proteins, response includes rash, red bumps, itching, and
blisters.
Reactive tuberculin test- PPD cause and induration in 24-72 if person was previously exposed to
tuberculin antigen
Solid organ transplant rejection- 11-14 days after 1st exposure, 5-6 days after 2nd exposure,
results in mononuclear infiltration, decreased circulation, and tissue necrosis.
Systemic Lupus Erythematosus - correct answer E. Primarily women aged 20-40, Type III
hypersensitivity. Antibodies are formed against DNA
Genetic, leads to tissue damage. Exacerbated by infections, UV light, estrogen, meds, stress
Diagnosed by serum ANA
C.M. Butterfly rash (cheeks), photosensitivity, nonerosive arthritis of at least 2 peripheral joints,
inflammation of serous sacs, proteinuria, seizures, anemia, leukopenia, thrombocytopenia
Rheumatoid Arthritis - correct answer E. Primarily women 30-50, systemic autoimmune disease
Progressive, irreversible leads to deformity and disability
Tx includes PT, NSAIDS, corticosteroids
