) Organic Chemistry | Questions &
Answers | Grade A | 100% Correct – Portage
Learning
Q: What is the difference between a nucleoside and nucleotide?
Answer
A nucleoside is formed from the covalent bonding of a base (purine or pyrimidine) to
either ribose (RNA) or 2-deoxyribose (DNA). Nucleotides are built from a nitrogen-
containing organic base, a monosaccharide, and phosphate.
Q: What characteristic makes purines and pyrimidine heterocyclic?
Answer
Each has a ring with nitrogen in the ring instead of all carbon atoms in the ring.
Q: Is this molecule ribose or 2-deoxyribose? Briefly explain what structural
information was used to determine this.
Answer
Ribose. This molecule contains an -OH on carbon 2. 2-deoxyribose has an -H atom on
the second carbon.
,Q: Is the following a pyrimidine or purine? Provide the name and one-letter symbol.
Answer
Pyrimidine. It is thymine (T).
Q: What is the difference between thymine and uracil?
Answer
These two bases differ by a methyl group. Thymine has an extra methyl group on the
ring.
Q: From the course and module information, where in a eukaryotic or prokaryotic cell,
is the DNA located? How about the RNA?
Answer
DNA is located in the nucleus of a eukaryotic cell or the nucleoid of a prokaryotic cell.
RNA is found in the nucleus, on the ribosome, and in other parts of the cell.
Q: Which DNA and RNA bases contain a carbonyl group?
Answer
Guanine, cytosine, thymine, and uracil all contain C=O group attached to the rings.
Adenine is the only base that does not.
,Q: What constitutes the backbone of DNA?
Answer
In DNA, this consists of the alternating deoxyribose and phosphate groups linked
together through covalent bonds.
Q: How many hydrogen bonds form between A and T?
Answer
Two hydrogen bonds are formed between these two bases. G and C form three H-bonds.
Q: Which nucleic acid is single-stranded?
Answer
RNA. RNA forms single strands. (Particularly, this was noted in this module for tRNA.)
DNA forms a double helix.
Q: What interactions stabilize the DNA double helix?
Answer
Hydrogen bonds stabilize the helix. Each AT pair and form two hydrogen bonds, and
each GC pair forms three hydrogens that stabilize the helix, permitting it to maintain
this shape.
, Q: What type of RNA has a sequence that is complementary to DNA?
Answer
mRNA is complementary so that it can transmit the information to the ribosome.
Q: Which has the largest molecular weight chains: mRNA, tRNA, or rRNA?
Answer
rRNA. These molecules make up ribosomes.
Q: What structural forms of DNA have a right-handed helix? Which form has a left-
handed helix?
Answer
The A- and B-forms are right-handed, while the Z-form is left-handed.
Q: What function does cAMP perform in cells?
Answer
cAMP is a communication molecule in cellular signaling. It acts as a secondary
messenger.