COMLEX-USA Level 2 CE Practice
Examination Newest 2025 – 2026 Questions From
Actual Exams Complete Questions And Correct
Detailed Answers (Verified Answers) |Already
Graded A+||Brand New!!
Content covered in this section (most commonly tested areas on
COMLEX Level 2 CE):
• Osteopathic Principles and OMT
• Internal Medicine (cardiology, pulmonology, endocrinology)
• Emergency Medicine
• Obstetrics and Gynecology
• Pediatrics
• Infectious Disease
• Neurology
• Preventive Medicine and Ethics
1. A 58-year-old man presents with crushing substernal chest pain radiating to the left arm
for 45 minutes. ECG shows ST elevation in leads II, III, and aVF. Which coronary artery
is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Answer: Right coronary artery
Inferior myocardial infarctions involve leads II, III, and aVF and are most commonly caused
by occlusion of the right coronary artery.
2. A 3-year-old child presents with barking cough, inspiratory stridor, and hoarseness that
worsens at night. What is the most likely diagnosis?
A. Epiglottitis
B. Croup
C. Bronchiolitis
D. Pertussis
,Answer: Croup
Croup (laryngotracheobronchitis) commonly presents with a barking cough and inspiratory
stridor in young children, usually caused by parainfluenza virus.
3. A patient with type 1 diabetes presents with nausea, vomiting, abdominal pain, and rapid
breathing. Labs show glucose 420 mg/dL, pH 7.18, and positive serum ketones. What is
the first step in management?
A. Insulin infusion
B. Intravenous fluids
C. Bicarbonate therapy
D. Potassium supplementation
Answer: Intravenous fluids
The first step in diabetic ketoacidosis treatment is aggressive IV fluid resuscitation to correct
dehydration.
4. A 45-year-old woman presents with fatigue, weight gain, and cold intolerance. Labs
show elevated TSH and low T4. What is the diagnosis?
A. Hyperthyroidism
B. Secondary hypothyroidism
C. Primary hypothyroidism
D. Thyroiditis
Answer: Primary hypothyroidism
Elevated TSH with low T4 indicates thyroid gland failure, consistent with primary
hypothyroidism.
5. A 24-year-old woman presents with right lower quadrant abdominal pain, fever, and
leukocytosis. What is the most likely diagnosis?
A. Ovarian torsion
B. Appendicitis
C. Ectopic pregnancy
D. Diverticulitis
Answer: Appendicitis
Right lower quadrant pain with fever and leukocytosis strongly suggests acute appendicitis.
, 6. A newborn develops jaundice on day 2 of life. Total bilirubin is elevated but direct
bilirubin is normal. What is the most likely cause?
A. Physiologic jaundice
B. Biliary atresia
C. Neonatal hepatitis
D. Hemolytic disease
Answer: Physiologic jaundice
Physiologic jaundice typically occurs between days 2–5 due to immature hepatic bilirubin
metabolism.
7. A 65-year-old man with chronic smoking history presents with progressive dyspnea and
productive cough. Spirometry shows decreased FEV1/FVC ratio. What is the likely
diagnosis?
A. Asthma
B. COPD
C. Pulmonary fibrosis
D. Sarcoidosis
Answer: COPD
Chronic obstructive pulmonary disease presents with obstructive spirometry and history of
smoking.
8. A patient presents with sudden unilateral facial paralysis including inability to close the
eye. What is the most likely diagnosis?
A. Stroke
B. Bell palsy
C. Trigeminal neuralgia
D. Multiple sclerosis
Answer: Bell palsy
Bell palsy involves peripheral facial nerve paralysis affecting the entire side of the face.
9. A pregnant woman at 10 weeks gestation presents for routine care. Which vitamin
supplementation is most important at this stage?
A. Vitamin D
B. Vitamin B12
Examination Newest 2025 – 2026 Questions From
Actual Exams Complete Questions And Correct
Detailed Answers (Verified Answers) |Already
Graded A+||Brand New!!
Content covered in this section (most commonly tested areas on
COMLEX Level 2 CE):
• Osteopathic Principles and OMT
• Internal Medicine (cardiology, pulmonology, endocrinology)
• Emergency Medicine
• Obstetrics and Gynecology
• Pediatrics
• Infectious Disease
• Neurology
• Preventive Medicine and Ethics
1. A 58-year-old man presents with crushing substernal chest pain radiating to the left arm
for 45 minutes. ECG shows ST elevation in leads II, III, and aVF. Which coronary artery
is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Answer: Right coronary artery
Inferior myocardial infarctions involve leads II, III, and aVF and are most commonly caused
by occlusion of the right coronary artery.
2. A 3-year-old child presents with barking cough, inspiratory stridor, and hoarseness that
worsens at night. What is the most likely diagnosis?
A. Epiglottitis
B. Croup
C. Bronchiolitis
D. Pertussis
,Answer: Croup
Croup (laryngotracheobronchitis) commonly presents with a barking cough and inspiratory
stridor in young children, usually caused by parainfluenza virus.
3. A patient with type 1 diabetes presents with nausea, vomiting, abdominal pain, and rapid
breathing. Labs show glucose 420 mg/dL, pH 7.18, and positive serum ketones. What is
the first step in management?
A. Insulin infusion
B. Intravenous fluids
C. Bicarbonate therapy
D. Potassium supplementation
Answer: Intravenous fluids
The first step in diabetic ketoacidosis treatment is aggressive IV fluid resuscitation to correct
dehydration.
4. A 45-year-old woman presents with fatigue, weight gain, and cold intolerance. Labs
show elevated TSH and low T4. What is the diagnosis?
A. Hyperthyroidism
B. Secondary hypothyroidism
C. Primary hypothyroidism
D. Thyroiditis
Answer: Primary hypothyroidism
Elevated TSH with low T4 indicates thyroid gland failure, consistent with primary
hypothyroidism.
5. A 24-year-old woman presents with right lower quadrant abdominal pain, fever, and
leukocytosis. What is the most likely diagnosis?
A. Ovarian torsion
B. Appendicitis
C. Ectopic pregnancy
D. Diverticulitis
Answer: Appendicitis
Right lower quadrant pain with fever and leukocytosis strongly suggests acute appendicitis.
, 6. A newborn develops jaundice on day 2 of life. Total bilirubin is elevated but direct
bilirubin is normal. What is the most likely cause?
A. Physiologic jaundice
B. Biliary atresia
C. Neonatal hepatitis
D. Hemolytic disease
Answer: Physiologic jaundice
Physiologic jaundice typically occurs between days 2–5 due to immature hepatic bilirubin
metabolism.
7. A 65-year-old man with chronic smoking history presents with progressive dyspnea and
productive cough. Spirometry shows decreased FEV1/FVC ratio. What is the likely
diagnosis?
A. Asthma
B. COPD
C. Pulmonary fibrosis
D. Sarcoidosis
Answer: COPD
Chronic obstructive pulmonary disease presents with obstructive spirometry and history of
smoking.
8. A patient presents with sudden unilateral facial paralysis including inability to close the
eye. What is the most likely diagnosis?
A. Stroke
B. Bell palsy
C. Trigeminal neuralgia
D. Multiple sclerosis
Answer: Bell palsy
Bell palsy involves peripheral facial nerve paralysis affecting the entire side of the face.
9. A pregnant woman at 10 weeks gestation presents for routine care. Which vitamin
supplementation is most important at this stage?
A. Vitamin D
B. Vitamin B12
