BMS 300 Reproduction Exam with verified detailed
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solutions
What sex determinants are present in females (XX)? - ✔✔Rspo1 and Wnt4/Betacatenin
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What sex determinants are present in males (XY)? - ✔✔Sry and Sox9
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Primoridal Germ Cell (PGC) differentiation in XX - ✔✔Mesonephros --> Retinoic Acid -->
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Gonad --> no CYP26B1 --> Meiotic entry PGCs
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Primoridal Germ Cell (PGC) differentiation in XY - ✔✔Mesonephros --> Retinoic Acid -->
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Gonad -->CYP26B1 --> No Meiotic entry PGCs
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True or False? Primary/Gonad sex differentiation does NOT depend on PGC differentiation.
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- ✔✔True
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Created by Wolffian Duct - ✔✔Epididymis (Testis), Vas Deferenes, Seminal Vesicle
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Created by Mullerian Duct - ✔✔Ovary (Oviduct/"Fallopian Tube"), Uterus, Upper 1/3 of
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Vagina
Removing the gonads of rabbits shows us that: - ✔✔The ovary does not do anything in
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development
Removing the gonads of rabbits, and adding testosterone shows us that: - ✔✔Male
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development relies greatly on testosterone. || || || ||
, Removing the gonads of rabbits and taking testis fragments, and putting them back in,
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shows us that: - ✔✔Anti-Mullerian Hormone is present and secreted by Sertoli cells and
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gets ride of the Mullerian Duct.
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Development of external genitalia can be bi-potential. Bi-potential means that: - ✔✔Either
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one of the two outcomes is possible, it just depends on the factors present, and what is
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released, and what is blocked.
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Androgen Insensitivity Syndrome (testicular feminization syndrome) - ✔✔Mutation in
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androgen receptor that causes: || || || ||
Chromosomal Sex: XX || ||
Gonadal Sex: Undescended testes
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Phenotypic Sex: female || ||
Androgen - ✔✔Sex Steroid Hormone. Testosterone (ovaries and testes).
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Dihydrotestosterone.
Estrogen - ✔✔Sex Steroid Hormone. Estradiol (ovaries and testes).
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Progesterone - ✔✔Sex Steroid Hormone. Precursor. || || || || ||
Steroid Hormones - ✔✔Lipophilic, intracellular receptors, and transcription.
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Where is sperm produced? - ✔✔Seminiferous tubules.
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Where is testosterone produced? - ✔✔Interstitial space.
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solutions
What sex determinants are present in females (XX)? - ✔✔Rspo1 and Wnt4/Betacatenin
|| || || || || || || || || || ||
What sex determinants are present in males (XY)? - ✔✔Sry and Sox9
|| || || || || || || || || || ||
Primoridal Germ Cell (PGC) differentiation in XX - ✔✔Mesonephros --> Retinoic Acid -->
|| || || || || || || || || || || || ||
Gonad --> no CYP26B1 --> Meiotic entry PGCs
|| || || || || || ||
Primoridal Germ Cell (PGC) differentiation in XY - ✔✔Mesonephros --> Retinoic Acid -->
|| || || || || || || || || || || || ||
Gonad -->CYP26B1 --> No Meiotic entry PGCs
|| || || || || ||
True or False? Primary/Gonad sex differentiation does NOT depend on PGC differentiation.
|| || || || || || || || || || || ||
- ✔✔True
||
Created by Wolffian Duct - ✔✔Epididymis (Testis), Vas Deferenes, Seminal Vesicle
|| || || || || || || || || ||
Created by Mullerian Duct - ✔✔Ovary (Oviduct/"Fallopian Tube"), Uterus, Upper 1/3 of
|| || || || || || || || || || || ||
Vagina
Removing the gonads of rabbits shows us that: - ✔✔The ovary does not do anything in
|| || || || || || || || || || || || || || || ||
development
Removing the gonads of rabbits, and adding testosterone shows us that: - ✔✔Male
|| || || || || || || || || || || || ||
development relies greatly on testosterone. || || || ||
, Removing the gonads of rabbits and taking testis fragments, and putting them back in,
|| || || || || || || || || || || || || ||
shows us that: - ✔✔Anti-Mullerian Hormone is present and secreted by Sertoli cells and
|| || || || || || || || || || || || || ||
gets ride of the Mullerian Duct.
|| || || || ||
Development of external genitalia can be bi-potential. Bi-potential means that: - ✔✔Either
|| || || || || || || || || || || ||
one of the two outcomes is possible, it just depends on the factors present, and what is
|| || || || || || || || || || || || || || || || ||
released, and what is blocked.
|| || || ||
Androgen Insensitivity Syndrome (testicular feminization syndrome) - ✔✔Mutation in
|| || || || || || || || ||
androgen receptor that causes: || || || ||
Chromosomal Sex: XX || ||
Gonadal Sex: Undescended testes
|| || || ||
Phenotypic Sex: female || ||
Androgen - ✔✔Sex Steroid Hormone. Testosterone (ovaries and testes).
|| || || || || || || || ||
Dihydrotestosterone.
Estrogen - ✔✔Sex Steroid Hormone. Estradiol (ovaries and testes).
|| || || || || || || ||
Progesterone - ✔✔Sex Steroid Hormone. Precursor. || || || || ||
Steroid Hormones - ✔✔Lipophilic, intracellular receptors, and transcription.
|| || || || || || ||
Where is sperm produced? - ✔✔Seminiferous tubules.
|| || || || || ||
Where is testosterone produced? - ✔✔Interstitial space.
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