PHARMACOLOGY 141 TEST 1 QUESTIONS AND
CORRECT ANSWERS (VERIFIED ANSWERS) PLUS
RATIONALES Q&A |INSTANT DOWNLOAD PDF
1. Which of the following factors influence drug absorption?
A. Route of administration
B. Blood flow to the site
C. Lipid solubility of the drug
D. Patient’s eye color
Rationale: Absorption depends on route, circulation, solubility,
and drug formulation; unrelated factors like eye color do not
affect it.
Correct Answer: A, B, C
2. The primary organ responsible for drug metabolism is:
A. Kidney
B. Liver
C. Lungs
D. Spleen
Rationale: The liver is the main site of enzymatic drug
metabolism via cytochrome P450.
Correct Answer: B
,3. A patient taking two drugs that compete for the same
receptor site may experience:
A. Synergistic effect
B. Antagonistic effect
C. Toxic effect
D. No effect
Rationale: Competition for the same receptor can block or
reduce drug action.
Correct Answer: B
4. Which of the following routes provides the fastest onset of
action?
A. Oral
B. Subcutaneous
C. Intravenous
D. Topical
Rationale: IV administration delivers drugs directly into
circulation for immediate effect.
Correct Answer: C
5. Which terms describe the amount of drug needed to
produce a therapeutic effect?
A. Potency
B. Efficacy
C. Half-life
,D. Bioavailability
Rationale: Potency refers to the dose required to achieve a
therapeutic effect; efficacy is the maximum effect a drug can
produce.
Correct Answer: A, B
6. The half-life of a drug is defined as:
A. Time for 50% of the drug to be absorbed
B. Time for 50% of the drug to be metabolized
C. Time for 50% of the drug to be eliminated from the body
D. Time for maximum effect
Rationale: Half-life measures how long it takes for the plasma
concentration of a drug to reduce by half.
Correct Answer: C
7. Which of the following drugs is considered a beta-blocker?
A. Atenolol
B. Lisinopril
C. Furosemide
D. Metformin
Rationale: Beta-blockers reduce heart rate and blood pressure;
atenolol is a classic example.
Correct Answer: A
, 8. Drugs that are highly protein-bound:
A. Have prolonged effects
B. Have rapid elimination
C. Easily cross membranes
D. Are inactive until metabolized
Rationale: Protein binding slows drug distribution and prolongs
effects.
Correct Answer: A
9. Which nursing intervention is important when
administering aminoglycosides?
A. Monitor liver function
B. Monitor kidney function
C. Monitor for ototoxicity
D. Monitor blood glucose
Rationale: Aminoglycosides can cause nephrotoxicity and
ototoxicity.
Correct Answer: B, C
10. A patient reports nausea after taking a new medication.
This is classified as a:
A. Therapeutic effect
B. Side effect
C. Adverse effect
D. Allergic reaction
CORRECT ANSWERS (VERIFIED ANSWERS) PLUS
RATIONALES Q&A |INSTANT DOWNLOAD PDF
1. Which of the following factors influence drug absorption?
A. Route of administration
B. Blood flow to the site
C. Lipid solubility of the drug
D. Patient’s eye color
Rationale: Absorption depends on route, circulation, solubility,
and drug formulation; unrelated factors like eye color do not
affect it.
Correct Answer: A, B, C
2. The primary organ responsible for drug metabolism is:
A. Kidney
B. Liver
C. Lungs
D. Spleen
Rationale: The liver is the main site of enzymatic drug
metabolism via cytochrome P450.
Correct Answer: B
,3. A patient taking two drugs that compete for the same
receptor site may experience:
A. Synergistic effect
B. Antagonistic effect
C. Toxic effect
D. No effect
Rationale: Competition for the same receptor can block or
reduce drug action.
Correct Answer: B
4. Which of the following routes provides the fastest onset of
action?
A. Oral
B. Subcutaneous
C. Intravenous
D. Topical
Rationale: IV administration delivers drugs directly into
circulation for immediate effect.
Correct Answer: C
5. Which terms describe the amount of drug needed to
produce a therapeutic effect?
A. Potency
B. Efficacy
C. Half-life
,D. Bioavailability
Rationale: Potency refers to the dose required to achieve a
therapeutic effect; efficacy is the maximum effect a drug can
produce.
Correct Answer: A, B
6. The half-life of a drug is defined as:
A. Time for 50% of the drug to be absorbed
B. Time for 50% of the drug to be metabolized
C. Time for 50% of the drug to be eliminated from the body
D. Time for maximum effect
Rationale: Half-life measures how long it takes for the plasma
concentration of a drug to reduce by half.
Correct Answer: C
7. Which of the following drugs is considered a beta-blocker?
A. Atenolol
B. Lisinopril
C. Furosemide
D. Metformin
Rationale: Beta-blockers reduce heart rate and blood pressure;
atenolol is a classic example.
Correct Answer: A
, 8. Drugs that are highly protein-bound:
A. Have prolonged effects
B. Have rapid elimination
C. Easily cross membranes
D. Are inactive until metabolized
Rationale: Protein binding slows drug distribution and prolongs
effects.
Correct Answer: A
9. Which nursing intervention is important when
administering aminoglycosides?
A. Monitor liver function
B. Monitor kidney function
C. Monitor for ototoxicity
D. Monitor blood glucose
Rationale: Aminoglycosides can cause nephrotoxicity and
ototoxicity.
Correct Answer: B, C
10. A patient reports nausea after taking a new medication.
This is classified as a:
A. Therapeutic effect
B. Side effect
C. Adverse effect
D. Allergic reaction
