HESI NCLEX-PN Examination
Review 2026 | Comprehensive Practice
Questions with Detailed Rationales
A 43-year-old female client who has had a thyroidectomy due to
Grave's disease is prescribed a thyroid replacement hormone. Which
signs and symptoms are associated with thyroid hormone toxicity and
should be reported promptly to the health care provider? - answer-a.
Tinnitus and dizziness
b. Tachycardia and chest pain
c. Dry skin and intolerance to cold
d. Weight gain and increased appetite
B
The dosing of heparin intravenous infusion is guided by which
laboratory value? - answer-a. Prothrombin time
b. Fibrin split products
c. Platelet count
d. Partial thromboplastin time
D
,A client receiving the antibiotic vancomycin is prescribed to have a peak
and trough level done with the next dose. What time should the
practical nurse obtain the blood specimen for the trough level? -
answer-a. 60 minutes after the antibiotic dose is administered.
b. Immediately before the next antibiotic dose is given.
c. When the next blood glucose level is to be checked.
d. 30 minutes before the next antibiotic dose is given.
B
The nurse is caring for a client who is taking prednisone to treat
rheumatoid arthritis. The nurse expects which aspect of care to be
emphasized with this client? - answer-a. Reducing the dose of insulin
b. Monitoring for hyperkalemia
c. Monitoring for substance abuse
d. Treating infections as soon as they occur
D
A client prescribed glipizide asked why they had to take their insulin
orally. How should the practical nurse respond? - answer-a. "Glipizide is
an oral form of insulin and has the same actions and properties as
intermediate insulin."
b. "Glipizide is an oral form of insulin and is distributed, metabolized,
and excreted in the same manner as insulin."
c. "Glipizide is not an oral form of insulin and can be used only when
some beta cell function is present."
,d. "Glipizide is not an oral form of insulin, but it is effective for those
who are resistant to injectable insulins."
C
The practical nurse administered carbidopa-levodopa to a client
diagnosed with Parkinson disease. Which outcome by the client would
indicate a therapeutic response?
a. Decreased blood pressure - answer-a. Decreased blood pressure
b. Lessening of tremors
c. Increased salivation
d. Increased attention span
B
The health care provider (HCP) has prescribed a 74-year-old client to be
vaccinated with the influenza vaccine prior to discharge. Which client
condition will make the practical nurse not to vaccinate the client and
consult with the charge nurse? - answer-a. History of congested heart
failure
b. History of an allergy to eggs
c. History of pneumococcal vaccination
d. History of end-stage renal disease
B
, A client who is taking hydrochlorothiazide is admitted to the hospital
and is experiencing muscle weakness and cramps. Which condition
should the practical nurse suspect is causing these changes? - answer-a.
Hypolipidemia
b. Hypermagnesemia
c. Hyperchloremia
d. Hyponatremia
D
A client who was diagnosed with oral thrush calls the clinic saying the
medication bottle broke and all of the medication was spilled. The
client is requesting a refill order. The nurse should contact the health
care provider about a refill for which medication? - answer-a. Ampicillin
b. Ciprofloxacin
c. Neomycin sulfate
d. Nystatin
D
A client with angina pectoris has been prescribed nitroglycerin tablets
prn for chest pain. Which statement by the client causes the practical
nurse (PN) to clarify instructions for this client? - answer-a. I will take
one tablet every 5 minutes, up to three tablets.
b. I should take one tablet at the onset of angina and stop activity.
c. I need to replace nitroglycerin tablets every 3 to 6 months to
maintain freshness.
Review 2026 | Comprehensive Practice
Questions with Detailed Rationales
A 43-year-old female client who has had a thyroidectomy due to
Grave's disease is prescribed a thyroid replacement hormone. Which
signs and symptoms are associated with thyroid hormone toxicity and
should be reported promptly to the health care provider? - answer-a.
Tinnitus and dizziness
b. Tachycardia and chest pain
c. Dry skin and intolerance to cold
d. Weight gain and increased appetite
B
The dosing of heparin intravenous infusion is guided by which
laboratory value? - answer-a. Prothrombin time
b. Fibrin split products
c. Platelet count
d. Partial thromboplastin time
D
,A client receiving the antibiotic vancomycin is prescribed to have a peak
and trough level done with the next dose. What time should the
practical nurse obtain the blood specimen for the trough level? -
answer-a. 60 minutes after the antibiotic dose is administered.
b. Immediately before the next antibiotic dose is given.
c. When the next blood glucose level is to be checked.
d. 30 minutes before the next antibiotic dose is given.
B
The nurse is caring for a client who is taking prednisone to treat
rheumatoid arthritis. The nurse expects which aspect of care to be
emphasized with this client? - answer-a. Reducing the dose of insulin
b. Monitoring for hyperkalemia
c. Monitoring for substance abuse
d. Treating infections as soon as they occur
D
A client prescribed glipizide asked why they had to take their insulin
orally. How should the practical nurse respond? - answer-a. "Glipizide is
an oral form of insulin and has the same actions and properties as
intermediate insulin."
b. "Glipizide is an oral form of insulin and is distributed, metabolized,
and excreted in the same manner as insulin."
c. "Glipizide is not an oral form of insulin and can be used only when
some beta cell function is present."
,d. "Glipizide is not an oral form of insulin, but it is effective for those
who are resistant to injectable insulins."
C
The practical nurse administered carbidopa-levodopa to a client
diagnosed with Parkinson disease. Which outcome by the client would
indicate a therapeutic response?
a. Decreased blood pressure - answer-a. Decreased blood pressure
b. Lessening of tremors
c. Increased salivation
d. Increased attention span
B
The health care provider (HCP) has prescribed a 74-year-old client to be
vaccinated with the influenza vaccine prior to discharge. Which client
condition will make the practical nurse not to vaccinate the client and
consult with the charge nurse? - answer-a. History of congested heart
failure
b. History of an allergy to eggs
c. History of pneumococcal vaccination
d. History of end-stage renal disease
B
, A client who is taking hydrochlorothiazide is admitted to the hospital
and is experiencing muscle weakness and cramps. Which condition
should the practical nurse suspect is causing these changes? - answer-a.
Hypolipidemia
b. Hypermagnesemia
c. Hyperchloremia
d. Hyponatremia
D
A client who was diagnosed with oral thrush calls the clinic saying the
medication bottle broke and all of the medication was spilled. The
client is requesting a refill order. The nurse should contact the health
care provider about a refill for which medication? - answer-a. Ampicillin
b. Ciprofloxacin
c. Neomycin sulfate
d. Nystatin
D
A client with angina pectoris has been prescribed nitroglycerin tablets
prn for chest pain. Which statement by the client causes the practical
nurse (PN) to clarify instructions for this client? - answer-a. I will take
one tablet every 5 minutes, up to three tablets.
b. I should take one tablet at the onset of angina and stop activity.
c. I need to replace nitroglycerin tablets every 3 to 6 months to
maintain freshness.
