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What is the RIFLE classification for acute renal failure? - ANSWER ✓ -Risk for
renal dysfunction
-Injury to the kidney
-Failure of kidney function
-Loss of kidney function
-Endstage kidney disease
(First three are grades of severity, last 2 are outcomes. Measures UO, GFR, and
creat)
Describe risk factors for AKI - ANSWER ✓ 1. CKD
2. Advanced age, diabetes, HTN, CHF, volume depletion
3. Nephrotoxic durgs: contrast agents, aminoglycosides, NSAIDs, ACE-I
4. "Heart-kidney connection" and cardiorenal syndrome: heart disease can
accelerate kidney problems; kidney disease speeds up heart disease
When giving contrast and other drugs which threaten kidney function, how can we
limit the risk of AKI? - ANSWER ✓ 1. Exposure to aminoglycosides,
amphotercin, and vanco: consider alternative agents, monitor peak and trough
levels, monitor renal function
2. Identify high risk patients: pre-existing renal insufficiency, Cr>1.5, DM, CHF,
dehydration, drugs
3. Prevention measures: screen patients pre-procedure; stop NSAIDs, ACE,
metformin, diuretics 24 hours prior to proecudre; hydration 8 hours before and 4
hours after
What is acetylcysteine - ANSWER ✓ Antioxidant that prevents renal tubular
damage, scavenges oxygen metabolites and prevents contrast-induced injury
, What are the clinical indications of hyperkalemia? - ANSWER ✓ -Irritable and
restless; anxiety; N/V; abdominal cramps; weakness; N/T; cardiac dysrhythmias
-ECG: Peaked T waves, widening QRS interval, V-tach or V-fib
How does Kayexalate work? - ANSWER ✓ Increases fecal potassium excretion
through binding of potassium in the lumen of GI tract
How does insulin and glucose work to lower serum potassium? - ANSWER ✓
Forces potassium out of the serum and into the cells
What kind of access is needed for hemodialysis or CRRT? - ANSWER ✓ Double
lumen catheter: although both lumens are in the vein, the aterial lumen carries
blood away from the heart, while venous lumen returns blood towards the heart
What are side effects of CRRT and dialysis? - ANSWER ✓ -Hemodialysis:
Hypotension, cramping, bleeding/clotting, dysrhythmias, hypoxia, dialysis,
disequilibrium syndrome
-Peritoneal dialysis: peritonitis, blocked catheter, incomplete recovery of fluid
-CRRT: dehydration, hypotension, electrolyte imbalance, hypothermia, clotted
filter, bleeding, complications of bedrest
List some of the key contraindications that may interfere with a patient's
candidacy for kidney transplant. - ANSWER ✓ -Malignancy during past 3 years
-Active infectious process
-Advanced cardiopulmonary disease
-High risk for surgery
-Non-adherence to current med regimen
-Drug or alcohol abuse
Describe the need for and potential longterm consequences of immunosuppressive
drug therapy. - ANSWER ✓ -Purpose: begins at time of transplantation, prevents
rejection and suppressing immune system until oral meds can be safely
administered and blood levels are sufficient
-Consequences:
1. Chronic immunosuppression: opportunistic infection, cancer
2. *Life long monitoring for rejection, infection and other complications of
immunosuppressive drugs*: HTN, renal failure, DM, osteoporosis