NUGGETS
PEDIATRICS MEDICINE
By: Shaheryar Ali Jafri
,DEDICATED TO……
, RICKETS NUGGETS........
1) Most common cause of rickets is nutritional deficency of vitamin D...... Low
Calcium----->High PTH----->Low Phosphate.... : <2 years.
2) Most common non-nutritional cause of rickets = VITAMIN D-RESISTANT
RICKETS.... X-linked dominant.....Everything is normal but PHOSPHATE LEVEL IS
VERY VERY VERY LOW....... >2 years
3) X-linked dominant diseases: xd rickets, incontentia pigmenti, fragile-x, charcot-
marrie tooth disease, Rett disease
4) Spnie and teeth abnormalities are more prominent in VIT-D RESISTANT
RICKETS; whereas head and thorax (rosary) deformities are more common in
Nutritional rickets...............
5) Vitamin D-dependant rickets is AUTOSOMAL RECESSIVE disease having two
types :
type-1 (Renal deficincy of 1-a-hydroxylase)
type-2: end organ resistance everywhere and increased 1-25 d3
6) VITAMIN D-RESISTANT RICKETS and Type-2 vitamin D dependant = both have
end organ resistance but the difference is k VIT-D-R has resistance mostly in
kidney leading to LOW PHOSPHATE while Type-2 vit.d.dpndt has resistance in
PEDIATRICS MEDICINE
By: Shaheryar Ali Jafri
,DEDICATED TO……
, RICKETS NUGGETS........
1) Most common cause of rickets is nutritional deficency of vitamin D...... Low
Calcium----->High PTH----->Low Phosphate.... : <2 years.
2) Most common non-nutritional cause of rickets = VITAMIN D-RESISTANT
RICKETS.... X-linked dominant.....Everything is normal but PHOSPHATE LEVEL IS
VERY VERY VERY LOW....... >2 years
3) X-linked dominant diseases: xd rickets, incontentia pigmenti, fragile-x, charcot-
marrie tooth disease, Rett disease
4) Spnie and teeth abnormalities are more prominent in VIT-D RESISTANT
RICKETS; whereas head and thorax (rosary) deformities are more common in
Nutritional rickets...............
5) Vitamin D-dependant rickets is AUTOSOMAL RECESSIVE disease having two
types :
type-1 (Renal deficincy of 1-a-hydroxylase)
type-2: end organ resistance everywhere and increased 1-25 d3
6) VITAMIN D-RESISTANT RICKETS and Type-2 vitamin D dependant = both have
end organ resistance but the difference is k VIT-D-R has resistance mostly in
kidney leading to LOW PHOSPHATE while Type-2 vit.d.dpndt has resistance in
