UAMS Blood Bank Exam #2 Final
Exam and All Correct Answers 2025-
2026 Updated.
Rh blood group system. D, C, E, c, and e. The D antigen is typically called the Rh factor. - Answer
What is the second most important blood bank system after ABO and what are the 5 principal
antigens? When Rh is referred to, what is most commonly being talked about?
Landsteiner and Weiner; Rh was the name given because of the similarity of this ABY to one
made by rabbits and guinea pigs that reacted with rhesus monkeys’ cells. It agglutinated with
85% of human RBCs. - Answer Who first recognized the Rh blood group in 1939 and how was
it named?
D antigen, it is very antigenic. Antibodies will be produced with exposure to even the smallest
amount of D AGN. Antibodies to the D AGN are one of the most clinically significant in blood
bank, because they are a major concern for both blood transfusions and HDN because they are
classified as IgG and can cross the placenta. - Answer What is the most important Rh
antigen? What is important to know about this one?
ABO is classified as IgM, acquired by bacterial or pollen ingestion. ABO also reacts at RT and are
antibodies present under normal conditions.
Rh is classified as IgG, acquired through immunization due to pregnancy or transfusions. Rh
reacts at 37 C and requires incubation and must have been formed by previous exposure. -
Answer When classifying ABO and Rh antibodies, what are the major comparison
differences?
Two closely linked genes (loci) on chromosome 1. RHD and RHCE. - Answer What is the most
widely accepted theory that describes inheritance of Rh?
RHD determines the D AGN expression on RBCs. RHCE determines the C, c, E, e expressions that
can be CE, Ce, cE, and ce. - Answer What does RHD and RHCE do?
C and c & E and e. D presence. d absence. - Answer Which alleles are co-dominant? What
represents the D allele? What represents the absence of the D allele?
D - 85%. d - 15% - Answer What is the frequency of the D AGN and the absence of the D AGN
(d)?
It is the DCE terminology; it states that AGN production is controlled by 3 sets of closely linked
(3 loci) genes located on the same chromosome and that each gene produces an AGN. There is
, a gene that controls D and d, a gene that controls C and c, and a gene that controls E and e. -
Answer What is the Fisher-Race Rh terminology?
It is the Rh-Hr terminology; it states that a single gene at the Rh locus codes for a series of
factors or the AGNs. Each parent contributes one Rh gene and can be inherited as homozygous
or heterozygous. 8 alleles - R0, R1, R2, RZ, r, r', r'', and ry.
R0 - Dce
R1 - DCe
R2 - DcE
RZ - DCE
r - dce
r' - dCe
r'' - dcE
ry - dCE - Answer What is the Wiener terminology? How many alleles exist at the Rh gene
locus with this theory? What are these alleles and how do they convert to the Fisher-Race
terminology?
Rosenfield terminology.
D-1
C-2
E-3
c-4
e - 5 - Answer Which Rh inheritance theory does not address gene inheritance but instead
reports only serological findings or phenotype by numbering the AGNs? How are they
numbered?
Genotype. Phenotype. - Answer What is the actual genetic makeup of an individual? What is
the outward expression of genes?
5 antisera - Anti-D, anti-C, anti-E, anti-c, and anti-e. - Answer What is used to determine Rh
or phenotype?
DCce. - Answer If a red cell is typed as D+, C+, E=, c+, and e+, what is the phenotype?
The D AGN is highly pleomorphic; the patient can have the D AGN but have it in a reduced
amount or have it with an altered structure that reduces its strength. The typing sera might
attach or sensitize to RBCs but will fail to agglutinate and will require additional testing. -
Answer What causes a weak expression of the Rh or D AGN? What happens if a patient has a
weak D expression and the typing sera is added?
Exam and All Correct Answers 2025-
2026 Updated.
Rh blood group system. D, C, E, c, and e. The D antigen is typically called the Rh factor. - Answer
What is the second most important blood bank system after ABO and what are the 5 principal
antigens? When Rh is referred to, what is most commonly being talked about?
Landsteiner and Weiner; Rh was the name given because of the similarity of this ABY to one
made by rabbits and guinea pigs that reacted with rhesus monkeys’ cells. It agglutinated with
85% of human RBCs. - Answer Who first recognized the Rh blood group in 1939 and how was
it named?
D antigen, it is very antigenic. Antibodies will be produced with exposure to even the smallest
amount of D AGN. Antibodies to the D AGN are one of the most clinically significant in blood
bank, because they are a major concern for both blood transfusions and HDN because they are
classified as IgG and can cross the placenta. - Answer What is the most important Rh
antigen? What is important to know about this one?
ABO is classified as IgM, acquired by bacterial or pollen ingestion. ABO also reacts at RT and are
antibodies present under normal conditions.
Rh is classified as IgG, acquired through immunization due to pregnancy or transfusions. Rh
reacts at 37 C and requires incubation and must have been formed by previous exposure. -
Answer When classifying ABO and Rh antibodies, what are the major comparison
differences?
Two closely linked genes (loci) on chromosome 1. RHD and RHCE. - Answer What is the most
widely accepted theory that describes inheritance of Rh?
RHD determines the D AGN expression on RBCs. RHCE determines the C, c, E, e expressions that
can be CE, Ce, cE, and ce. - Answer What does RHD and RHCE do?
C and c & E and e. D presence. d absence. - Answer Which alleles are co-dominant? What
represents the D allele? What represents the absence of the D allele?
D - 85%. d - 15% - Answer What is the frequency of the D AGN and the absence of the D AGN
(d)?
It is the DCE terminology; it states that AGN production is controlled by 3 sets of closely linked
(3 loci) genes located on the same chromosome and that each gene produces an AGN. There is
, a gene that controls D and d, a gene that controls C and c, and a gene that controls E and e. -
Answer What is the Fisher-Race Rh terminology?
It is the Rh-Hr terminology; it states that a single gene at the Rh locus codes for a series of
factors or the AGNs. Each parent contributes one Rh gene and can be inherited as homozygous
or heterozygous. 8 alleles - R0, R1, R2, RZ, r, r', r'', and ry.
R0 - Dce
R1 - DCe
R2 - DcE
RZ - DCE
r - dce
r' - dCe
r'' - dcE
ry - dCE - Answer What is the Wiener terminology? How many alleles exist at the Rh gene
locus with this theory? What are these alleles and how do they convert to the Fisher-Race
terminology?
Rosenfield terminology.
D-1
C-2
E-3
c-4
e - 5 - Answer Which Rh inheritance theory does not address gene inheritance but instead
reports only serological findings or phenotype by numbering the AGNs? How are they
numbered?
Genotype. Phenotype. - Answer What is the actual genetic makeup of an individual? What is
the outward expression of genes?
5 antisera - Anti-D, anti-C, anti-E, anti-c, and anti-e. - Answer What is used to determine Rh
or phenotype?
DCce. - Answer If a red cell is typed as D+, C+, E=, c+, and e+, what is the phenotype?
The D AGN is highly pleomorphic; the patient can have the D AGN but have it in a reduced
amount or have it with an altered structure that reduces its strength. The typing sera might
attach or sensitize to RBCs but will fail to agglutinate and will require additional testing. -
Answer What causes a weak expression of the Rh or D AGN? What happens if a patient has a
weak D expression and the typing sera is added?
