Lithium - Answers a salt that is prescribed for its ability to stabilize the mania associated with bipolar
disorder
Lithium therapeutic range - Answers 0.6-1.2 mEq/L
Lithium acute mania - Answers 1.0-1.5 mEq/L
Lithium lag period - Answers 7-10 days
Lithium Impacts - Answers Drugs that increase or decrease serum sodium levels have impact of
lithium levels
Lithium Toxicity - Answers Tremors, Metallic taste, neuro symptoms besides parenthesia
Lithium level monitoring - Answers Monitored once or twice a week after initial treatment until
dosage serum levels are stable and then monthly during maintenance therapy.
Blood samples drawn 12 hours after last dose
Lithium toxicity >1.2 or <1.2 in elderly
(most common 1.5) - Answers Early signs Vomiting, Diarrhea
Lithium Toxicity >2mEq/L - Answers Tremors, Sedation, Confusion,
Lithium Toxicity >3.5 mEq/L - Answers delirium, seizures, coma, cardiovascular collapse, death
Lithium Toxicity Masking - Answers Chlorpromazine may mask early signs of lithium toxicity
Nursing interventions for Lithium - Answers Instruct patients to report all medications, herbals, and
caffeine use to physician or nurse practitioner to evaluate for drug interactions
Encourage patients to maintain fluid intake at 2,000-3,000 mL/day and avoid activities in which
excessive sweating and fluid loss are a risk because inadequate fluid intake can affect lithium levels.
Patient teaching of Lithium - Answers Instruct patients about the importance of regular monitoring of
serum lithium levels
Lithium contraindications - Answers Cardiovascular disease
Brain damage
Renal disease
Thyroid disease
Myasthenia gravis
Pregnancy
Breastfeeding mothers
Children younger than 12 years
Increased suicide risk Lithium - Answers Assess for suicide risk regularly and inform patients of risks
associated with anticonvulsants.
Hyponatremia (Lithium) - Answers Instruct patients to maintain usual dietary intake of sodium.
Assess for and educate patients to report any episodes of nausea, vomiting, headache, muscle
weakness, confusion, seizures, because these may be signs of hyponatremia.
Hypotension (Lithium) - Answers Monitor vital signs and instruct patients to report any symptoms of
dizziness or palpitations
Drowsiness (Lithium) - Answers Instruct patients to avoid driving or operating dangerous machinery
when experiencing this side effect.
Assess patients' mental status for level of alertness.
Lithium administration - Answers take with milk and maintain sodium
Divalproex Side Effects - Answers Abdominal pain, alopecia, asthenia, diarrhea, diplopia, dizziness,
headache, nausea, somnolence, tremor, vomiting
Divalproex Client education - Answers Divalproex sodium should be taken with food, so take your
doses with a snack or just after you have had a meal. If you have been given delayed or extended
release tablets, swallow them whole with a drink of water. Do not chew or crush the tablets because
they have a special protective coating
Lamotrigine (Lamictal) - Answers anticonvulsant/mood stabilizer
Lamotrigine side effects - Answers ataxia, dizziness
headache
n/v/ anorexia
, diplopia, blurred vision
abdominal pain, dysmenorrhea
loss of coordination
mood changes
irritability
insomnia
depression
Lamotrigine adverse effects - Answers Flu like symptoms, worsening depression or suicidal thoughts,
or severe rash. Report any of these symptoms to Doctor immediately
lamotrigine education - Answers Swallow the tablet whole and do not break, crush, or chew it.
Carbamzepine (Tegretol) - Answers Anticonvulsant
Na+ channel blocker
GABAA agonist
Carbamzepine Side Effects - Answers Dizziness, loss of coordination, problems with walking, N/V, and
drowsiness
Watch for changes in mental status
Carbamazepine education - Answers Don't take with grapefruit juice
Depression Predisposing Factors - Answers Genetic
Biochemical
Neuroendocrine Disturbances
Substance Intoxication and withdraw
Medication side effect
Types of mood disorders - Answers Major depressive disorder (MDD)
Bipolar I
Bipolar II
Dysthymia
Cyclothymia
Depression Interventions - Answers Major goal: increase self-esteem 2. Schedule activities of daily
living ( structure activities for success) 3. Encourage appropriate amounts of sleep 4. Family or group
therapy 5. Unconditional acceptance 6. Encourage expression of feelings
Disruptive Mood Dysregulation Disorder - Answers a childhood disorder marked by severe recurrent
temper outbursts along with a persistent irritable or angry mood
major depressive disorder - Answers A mood disorder in which a person experiences, in the absence
of drugs or a medical condition, two or more weeks of significantly depressed moods, feelings of
worthlessness, and diminished interest or pleasure in most activities.
5 or more of the following symptoms:
* Depressed mood, sad, empty, hopeless Irritability in child/adolescents
* Anhedonia
* Significant weight change
* Sleep insomnia/hypersomnia nearly daily
* Fatigue/anergia nearly daily
* Psychomotor agitation/retardation
* Excessive feelings of guilt or worthlessness.
* Inability to think/concentrate/indecisive
* Recurrent thoughts of death or suicidal ideation
Persistent Depressive Disorder - Answers a form of depression that is not severe enough to be
diagnosed as major depressive disorder, but is comparable in symptoms
Similar s/sx to MDD but milder.
Mood sad No psychosis
Minimal impairment in social and occupational fx.
Essential feature: chronically depressed mood (or irritable) for most of the day, more days than not
for at least 2 yrs.
Premenstrual Dysphoric Disorder - Answers a disorder marked by repeated episodes of significant
depression and related symptoms during the week before menstruation