FUNDAMENTALS OF CHEMOTHERAPY
IMMUNOTHERAPY ADMINISTRATION
TEST EXAM WITH CORRECT ACTUAL
QUESTIONS AND CORRECTLY WELL
DEFINED ANSWERS LATEST ALREADY
GRADED A+
Adjuvant therapy - ANSWERS-Chemo AFTER primary
treatment (common in solid tumor)
Bone Marrow - ANSWERS-soft, sponge-like tissue in center
of most bones, produce WBC, RBC, and platelets.
Myelosuppression - ANSWERS-bone marrow activity is
decreased, causing less RBC, WBC and Platelets.
Myeloablation - ANSWERS-severe myelosuppression
Induction phase - ANSWERS-initial phase, typically in
hospital, intended myelosuppression
,Consolidation phase (intensification/postremission therapy)
- ANSWERS-after successful induction, kills cancer cells left
in body (ex radiation, stem cell transplant)
Synergy - ANSWERS-when one chemo drug helps another
work better at the same time
Complete response - ANSWERS-no identifiable cancer
present for at least one month or longer
Partial response - ANSWERS-Measurable tumor reduced by
50% for at least one month with no new tumors
Stable disease - ANSWERS-Tumor size reduced by less than
50% or less than 25% increase in growth
Progressive disease - ANSWERS-tumor growth more than
25% or new cancer
What are the phases of the cell cycle? - ANSWERS--G1 phase
-S phase
, -G2 phase
-M phase
What happens in G1 phase? - ANSWERS-The cell increases in
size and prepares to replicate its DNA.
What do chemo drugs do to target S phase? - ANSWERS-
Prevent cell from making DNA and/or RNA (replicating)
(ex: antifolates (methotrexate), antipyrimidines (5-fu),
antipurines (hydroxyurea))
What do chemo drugs do to target G2 phase? - ANSWERS-
Cells prepare to divide, chemo drugs stop development of
elements needed for cell division
(ex: topoisomerase I and II inhibitors, bleomycin)
What do chemo drugs do to target M phase? - ANSWERS-
Cells divide, drugs prevent cell division, including
metaphase arrest or microtubular disorganization
(ex: plant alkaloids and taxanes)
What are some examples of cell cycle non-specific drugs? -
ANSWERS-Active throughout the cell cycle:
IMMUNOTHERAPY ADMINISTRATION
TEST EXAM WITH CORRECT ACTUAL
QUESTIONS AND CORRECTLY WELL
DEFINED ANSWERS LATEST ALREADY
GRADED A+
Adjuvant therapy - ANSWERS-Chemo AFTER primary
treatment (common in solid tumor)
Bone Marrow - ANSWERS-soft, sponge-like tissue in center
of most bones, produce WBC, RBC, and platelets.
Myelosuppression - ANSWERS-bone marrow activity is
decreased, causing less RBC, WBC and Platelets.
Myeloablation - ANSWERS-severe myelosuppression
Induction phase - ANSWERS-initial phase, typically in
hospital, intended myelosuppression
,Consolidation phase (intensification/postremission therapy)
- ANSWERS-after successful induction, kills cancer cells left
in body (ex radiation, stem cell transplant)
Synergy - ANSWERS-when one chemo drug helps another
work better at the same time
Complete response - ANSWERS-no identifiable cancer
present for at least one month or longer
Partial response - ANSWERS-Measurable tumor reduced by
50% for at least one month with no new tumors
Stable disease - ANSWERS-Tumor size reduced by less than
50% or less than 25% increase in growth
Progressive disease - ANSWERS-tumor growth more than
25% or new cancer
What are the phases of the cell cycle? - ANSWERS--G1 phase
-S phase
, -G2 phase
-M phase
What happens in G1 phase? - ANSWERS-The cell increases in
size and prepares to replicate its DNA.
What do chemo drugs do to target S phase? - ANSWERS-
Prevent cell from making DNA and/or RNA (replicating)
(ex: antifolates (methotrexate), antipyrimidines (5-fu),
antipurines (hydroxyurea))
What do chemo drugs do to target G2 phase? - ANSWERS-
Cells prepare to divide, chemo drugs stop development of
elements needed for cell division
(ex: topoisomerase I and II inhibitors, bleomycin)
What do chemo drugs do to target M phase? - ANSWERS-
Cells divide, drugs prevent cell division, including
metaphase arrest or microtubular disorganization
(ex: plant alkaloids and taxanes)
What are some examples of cell cycle non-specific drugs? -
ANSWERS-Active throughout the cell cycle:
