COMLEX LEVEL 2 Arc Deck 3
2026 Exam Questions and
Correct Answers | New Update
What is Wiskott-Aldrich Syndrome (WAS) inheritance? - 🧠 ANSWER ✔✔X-
linked recessive immunodeficiency
What is the classic triad of Wiskott-Aldrich Syndrome? - 🧠 ANSWER
✔✔Eczema, recurrent infections, thrombocytopenia with small platelets
,What is the expected finding in a CBC with peripheral smear for Wiskott-
Aldrich Syndrome? - 🧠 ANSWER ✔✔Decreased platelet count with small
platelets (low MPV)
What are the expected immunoglobulin levels in Wiskott-Aldrich
Syndrome? - 🧠 ANSWER ✔✔Decreased IgM, increased IgA and IgE
What genetic testing result confirms Wiskott-Aldrich Syndrome? - 🧠
ANSWER ✔✔Mutation in the WASP gene
What are the common symptoms of Bernard-Soulier syndrome? - 🧠
ANSWER ✔✔Mucosal bleeding (epistaxis, menorrhagia, gingival bleeding),
bleeding since childhood, large platelets on smear, normal platelet count or
mild thrombocytopenia.
What is the expected finding in a CBC with peripheral smear for Bernard-
Soulier syndrome? - 🧠 ANSWER ✔✔Normal to decreased platelets, giant
platelets.
What is the expected result of the bleeding time test in Bernard-Soulier
syndrome? - 🧠 ANSWER ✔✔Prolonged bleeding time.
,What does a platelet function assay or aggregometry show in Bernard-
Soulier syndrome? - 🧠 ANSWER ✔✔Decreased aggregation with ristocetin
(no correction with normal plasma).
What is the confirmatory test for Bernard-Soulier syndrome? - 🧠 ANSWER
✔✔Flow cytometry showing decreased or absent GP1b receptor.
What type of hypersensitivity is heparin-induced thrombocytopenia (HIT)? -
🧠 ANSWER ✔✔Type II hypersensitivity
What do antibodies form against in heparin-induced thrombocytopenia
(HIT)? - 🧠 ANSWER ✔✔PF4-heparin complexes
When does heparin-induced thrombocytopenia (HIT) typically occur after
starting heparin? - 🧠 ANSWER ✔✔5-10 days
What is the first test to confirm heparin-induced thrombocytopenia (HIT)? -
🧠 ANSWER ✔✔ELISA for anti-PF4 antibodies
What is the second test used to confirm heparin-induced thrombocytopenia
(HIT) after ELISA? - 🧠 ANSWER ✔✔Serotonin release assay (SRA)
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED
, What is the first step in the management of heparin-induced
thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔STOP all heparin (including
LMWH!)
What type of anticoagulants should be started in the management of
heparin-induced thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔Non-heparin
anticoagulants like argatroban, fondaparinux, or bivalirudin
When should warfarin be avoided in patients with heparin-induced
thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔Until platelets are >150k
How to determine LVH on EKG? - 🧠 ANSWER ✔✔count S wave boxes V2
+ T wave boxes V4-V5 if > 30 the pt has LVH
Cushing syndrome causes - 🧠 ANSWER ✔✔- Iatrogenic (from
corticosteroid therapy)
- Adrenocortical adenoma (secretes excess cortisol)
- ACTH-secreting pituitary adenoma (Cushing disease)
- Paraneoplastic (due to ACTH secretion by tumors)
Step dx algorithm for Cushing - 🧠 ANSWER ✔✔Step 1: Confirm
hypercortisolism
2026 Exam Questions and
Correct Answers | New Update
What is Wiskott-Aldrich Syndrome (WAS) inheritance? - 🧠 ANSWER ✔✔X-
linked recessive immunodeficiency
What is the classic triad of Wiskott-Aldrich Syndrome? - 🧠 ANSWER
✔✔Eczema, recurrent infections, thrombocytopenia with small platelets
,What is the expected finding in a CBC with peripheral smear for Wiskott-
Aldrich Syndrome? - 🧠 ANSWER ✔✔Decreased platelet count with small
platelets (low MPV)
What are the expected immunoglobulin levels in Wiskott-Aldrich
Syndrome? - 🧠 ANSWER ✔✔Decreased IgM, increased IgA and IgE
What genetic testing result confirms Wiskott-Aldrich Syndrome? - 🧠
ANSWER ✔✔Mutation in the WASP gene
What are the common symptoms of Bernard-Soulier syndrome? - 🧠
ANSWER ✔✔Mucosal bleeding (epistaxis, menorrhagia, gingival bleeding),
bleeding since childhood, large platelets on smear, normal platelet count or
mild thrombocytopenia.
What is the expected finding in a CBC with peripheral smear for Bernard-
Soulier syndrome? - 🧠 ANSWER ✔✔Normal to decreased platelets, giant
platelets.
What is the expected result of the bleeding time test in Bernard-Soulier
syndrome? - 🧠 ANSWER ✔✔Prolonged bleeding time.
,What does a platelet function assay or aggregometry show in Bernard-
Soulier syndrome? - 🧠 ANSWER ✔✔Decreased aggregation with ristocetin
(no correction with normal plasma).
What is the confirmatory test for Bernard-Soulier syndrome? - 🧠 ANSWER
✔✔Flow cytometry showing decreased or absent GP1b receptor.
What type of hypersensitivity is heparin-induced thrombocytopenia (HIT)? -
🧠 ANSWER ✔✔Type II hypersensitivity
What do antibodies form against in heparin-induced thrombocytopenia
(HIT)? - 🧠 ANSWER ✔✔PF4-heparin complexes
When does heparin-induced thrombocytopenia (HIT) typically occur after
starting heparin? - 🧠 ANSWER ✔✔5-10 days
What is the first test to confirm heparin-induced thrombocytopenia (HIT)? -
🧠 ANSWER ✔✔ELISA for anti-PF4 antibodies
What is the second test used to confirm heparin-induced thrombocytopenia
(HIT) after ELISA? - 🧠 ANSWER ✔✔Serotonin release assay (SRA)
COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED
, What is the first step in the management of heparin-induced
thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔STOP all heparin (including
LMWH!)
What type of anticoagulants should be started in the management of
heparin-induced thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔Non-heparin
anticoagulants like argatroban, fondaparinux, or bivalirudin
When should warfarin be avoided in patients with heparin-induced
thrombocytopenia (HIT)? - 🧠 ANSWER ✔✔Until platelets are >150k
How to determine LVH on EKG? - 🧠 ANSWER ✔✔count S wave boxes V2
+ T wave boxes V4-V5 if > 30 the pt has LVH
Cushing syndrome causes - 🧠 ANSWER ✔✔- Iatrogenic (from
corticosteroid therapy)
- Adrenocortical adenoma (secretes excess cortisol)
- ACTH-secreting pituitary adenoma (Cushing disease)
- Paraneoplastic (due to ACTH secretion by tumors)
Step dx algorithm for Cushing - 🧠 ANSWER ✔✔Step 1: Confirm
hypercortisolism
