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Family Medicine COMAT (NBOME COMAT-FM) – 300 Questions – Primary Care, Internal Medicine, Pediatrics, OB/GYN Q&A 2026

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This document provides a comprehensive collection of approximately 300 high-yield Family Medicine COMAT-style questions and answers, designed to enhance rapid recall, diagnostic reasoning, and exam performance. It covers a wide spectrum of primary care topics including internal medicine, pediatrics, obstetrics and gynecology, cardiology, endocrinology, infectious diseases, dermatology, rheumatology, and preventive medicine. Early sections (pages 1–5) focus on foundational clinical concepts such as asthma severity classification, thyroid disorders (Graves, Hashimoto), acute otitis media management, and cardiovascular pathophysiology, while later sections expand into advanced topics including screening guidelines, chronic disease management, autoimmune conditions, infectious disease protocols, and pharmacologic treatments. The document integrates high-yield clinical associations, diagnostic criteria, and evidence-based management strategies essential for COMAT and board exams. It includes detailed coverage of outpatient medicine such as hypertension, diabetes, COPD, asthma, GERD, and osteoarthritis, alongside preventive care guidelines including vaccination schedules, cancer screening (e.g., mammograms, colonoscopy), and risk stratification tools. Additionally, it highlights critical exam-tested concepts such as infectious disease management (e.g., CAP, TB, HIV prophylaxis), OB/GYN care (e.g., prenatal screening, contraception, pregnancy-safe medications), pediatric conditions (e.g., developmental milestones, bronchiolitis, congenital disorders), and emergency presentations (e.g., stroke, anaphylaxis, DVT). The structured Q&A format supports active recall and spaced repetition, making it highly effective for final-stage revision. This resource is highly relevant for courses such as Family Medicine Clerkship, Primary Care Medicine, Internal Medicine, Pediatrics, Obstetrics & Gynecology, and Preventive Medicine. It is ideal for osteopathic medical students (DO programs) preparing for the Family Medicine COMAT exam (NBOME), as well as students preparing for COMLEX Level 2-CE and USMLE Step 2 CK. It is also suitable for physician assistant (PA) students, nursing students, and international medical graduates seeking a comprehensive primary care review resource. The content aligns closely with widely used board preparation textbooks such as First Aid for the USMLE Step 2 CK, Step-Up to Medicine, and COMAT review guides, making it a powerful supplementary tool for consolidating high-yield knowledge, improving diagnostic accuracy, and maximizing exam performance. Keywords: family medicine, COMAT, primary care, internal medicine, pediatrics, obstetrics, gynecology, preventive medicine, cardiology, endocrinology, infectious disease, hypertension, diabetes, asthma, COPD, screening guidelines, vaccination, board exam preparation

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Institution
Family Medicine
Course
Family medicine

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Family Medicine COMAT

Intermittent Asthma - 🧠 ANSWER ✔✔Symptoms <2 days/week; normal

PFT.


Mild Persistent Asthma - 🧠 ANSWER ✔✔Symptoms >2 days/week; minor

activity limitations.


Moderate Persistent Asthma - 🧠 ANSWER ✔✔Daily symptoms; FEV1 60-

79% predicted.


Severe Persistent Asthma - 🧠 ANSWER ✔✔Symptoms throughout the day;

FEV1 <60%.

,Graves Disease - 🧠 ANSWER ✔✔Elevated thyroxine causes palpitations

and weight loss.


Grave's Ophthalmopathy - 🧠 ANSWER ✔✔Orbital fibroblast activation

causes muscle swelling.


Hashimoto's Disease - 🧠 ANSWER ✔✔Presence of thyroid peroxidase

antibodies.


Diabetic Retinopathy - 🧠 ANSWER ✔✔Reduced visual acuity; fundoscopic

exam shows microaneurysms.


Macular Degeneration - 🧠 ANSWER ✔✔Common blindness cause; affects

fine visual acuity.


Upper GI Bleeding - 🧠 ANSWER ✔✔Elevated BUN/creatinine ratio

indicates hemoglobin breakdown.


Acute Otitis Media - 🧠 ANSWER ✔✔Treatment of choice is oral amoxicillin.


Chronic Mitral Regurgitation - 🧠 ANSWER ✔✔Increased left ventricular end

diastolic volume.


Pulmonary Arterial Hypertension - 🧠 ANSWER ✔✔Vasoconstriction from

chronic hypoxemia.

,Housemaid's Knee - 🧠 ANSWER ✔✔Also known as prepatellar bursitis.


Von Willebrand Disease - 🧠 ANSWER ✔✔Most common inherited bleeding

disorder.


Echinococcus Granulosus - 🧠 ANSWER ✔✔Causes hydatid disease; cystic

liver lesions.


Entamoeba Histolytica - 🧠 ANSWER ✔✔Causes amebic liver abscesses;

hypoechoic mass.


Tinea Versicolor - 🧠 ANSWER ✔✔Fungal infection; KOH shows 'spaghetti

and meatballs'.


Mitral Stenosis - 🧠 ANSWER ✔✔Late diastolic murmur with opening snap.


Primary Hyperparathyroidism - 🧠 ANSWER ✔✔Causes hypercalcemia;

leads to bone pain.


Osteosarcoma - 🧠 ANSWER ✔✔Primary bone malignancy; sunburst

pattern on X-ray.


BMI Classification - 🧠 ANSWER ✔✔Underweight: <18.5; Obesity: >30.




COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED

, Chronic Anal Fissure - 🧠 ANSWER ✔✔Initial treatment includes fiber and

topical analgesics.


Open-Angle Glaucoma - 🧠 ANSWER ✔✔Loss of peripheral vision;

increased cup:disc ratio.


Heart Disease Risk Factors - 🧠 ANSWER ✔✔Family history of heart attack

before age 65.


Pneumococcal Vaccine - 🧠 ANSWER ✔✔Recommended for adults 65+

with updated vaccinations.


FAP Management - 🧠 ANSWER ✔✔Colectomy after adenomatous polyps

removal.


E. Coli Urinalysis - 🧠 ANSWER ✔✔Positive for leukocyte esterase and

nitrates.


Diuretics and Gout - 🧠 ANSWER ✔✔Loop and thiazide diuretics cause

hyperuricemia.


Lactose Deficiency Test - 🧠 ANSWER ✔✔Definitive test is hydrogen breath

test.

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Institution
Family medicine
Course
Family medicine

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Uploaded on
March 18, 2026
Number of pages
56
Written in
2025/2026
Type
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