APHON Principles of Chemo and Biotherapy Exam ||
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6 essential alterations in normal cell physiology that dictate
malignant growth -
ANSWER -1. Self-sufficiency in growth signals 2.
Insensitivity to growth-
inhibitory signals 3. Avoidance of apoptosis 4. Limitless
replication potential 5.
Sustained antiangiogenesis 6. Tissue invasion
and metastasis
6 cell characteristics of malignant cells in easier terms -
ANSWER -Mutated
DNA alters instructions for function 2. Parasitic to host and has
no beneficial
function 3. Uncontrolled reproduction 4. Invades surrounding
tissues and mets
5. Immortal 6. Call birth is greater then
cell death
, 6 mechanisms of drug resistance by the cell - ANSWER -1.
Decreased drug uptake by the cell 2. Increased removal of the
drug out of the cell r/t changes in the cell membrane 3.
Detoxification of the drug in the cell r/t metabolic changes 4.
Increased repair of DNA 5. Alterations in the structure of drug
receptor sites
6. Decreased sensitivity to apoptosis.
MDR1 - ANSWER -Multidrug resistance gene 1. May occur prior
to exposure of
chemo or after. Caused by the presence of P-
glycoprotein
How should chemo be administered to maximize effectiveness?
- ANSWER -At
the maximum tolerated doses with the shortest
possible interval
What are chemotherapy effects on the cell cycle with cell cycle
specific drugs? -
ANSWER -1. Greatest effect on actively dividing cells 2.
NOT active in G0
phase 3. Greatest action in divided doses or continuous
infusion 4. Cytotoxic
effects occur when cell repair or division is
attempted
Most Recent Exam 2026-2027 Actual Complete Real
Exam Questions And Correct Answers (Verified
Answers) Already Graded A+ | Guaranteed
Success!! Newest Exam | Just Released!!
6 essential alterations in normal cell physiology that dictate
malignant growth -
ANSWER -1. Self-sufficiency in growth signals 2.
Insensitivity to growth-
inhibitory signals 3. Avoidance of apoptosis 4. Limitless
replication potential 5.
Sustained antiangiogenesis 6. Tissue invasion
and metastasis
6 cell characteristics of malignant cells in easier terms -
ANSWER -Mutated
DNA alters instructions for function 2. Parasitic to host and has
no beneficial
function 3. Uncontrolled reproduction 4. Invades surrounding
tissues and mets
5. Immortal 6. Call birth is greater then
cell death
, 6 mechanisms of drug resistance by the cell - ANSWER -1.
Decreased drug uptake by the cell 2. Increased removal of the
drug out of the cell r/t changes in the cell membrane 3.
Detoxification of the drug in the cell r/t metabolic changes 4.
Increased repair of DNA 5. Alterations in the structure of drug
receptor sites
6. Decreased sensitivity to apoptosis.
MDR1 - ANSWER -Multidrug resistance gene 1. May occur prior
to exposure of
chemo or after. Caused by the presence of P-
glycoprotein
How should chemo be administered to maximize effectiveness?
- ANSWER -At
the maximum tolerated doses with the shortest
possible interval
What are chemotherapy effects on the cell cycle with cell cycle
specific drugs? -
ANSWER -1. Greatest effect on actively dividing cells 2.
NOT active in G0
phase 3. Greatest action in divided doses or continuous
infusion 4. Cytotoxic
effects occur when cell repair or division is
attempted
