TDM/TOXICOLOGY/DRUG OF ABUSE QUESTIONS WITH COMPLETE SOLUTION 2025/2026

TDM/TOXICOLOGY/DRUG OF ABUSE
QUESTIONS WITH COMPLETE
SOLUTION 2025/2026
TDM - correct answer ✔Analysis, assessment and evaluation of drugs in blood.



First-pass hepatic metabolism - correct answer ✔drugs that are transported to the liver lost a fraction
of its bioavailability



Bioavailable fraction - correct answer ✔fraction of the dose that reaches the blood



Peak concentration - correct answer ✔Highest conc. of a drug obtained in the dosing interval



Trough concentration - correct answer ✔Lowest conc. of a drug obtained in the dosing interval



Serum or Plasma - correct answer ✔specimen of choice for the determination of circulating
concentrations of most drugs



Heparin plasma - correct answer ✔suitable for most drug analysis



EDTA, Citrated, and Oxalated Plasma - correct answer ✔Rejected in TDM



5 Pharmacological Parameters - correct answer ✔Liberation

Absorption

Distribution

Metabolism

, Excretion



Liberation - correct answer ✔the release of drug



Absorption - correct answer ✔Transport of drug to the blood



Distriburion - correct answer ✔Delivery of drug to the tissue



Metabolism - correct answer ✔Chemical modification of drug by cells



Excretion - correct answer ✔Elimination of drug or its metabolite



Cardioactive Drugs (DLQ) - correct answer ✔Digoxin

Lidocaine(Xylocaine)

Quinidine



Digoxin - correct answer ✔For treating CHF



Lidocaine (Xylocaine) - correct answer ✔Correct ventricular arrhythmia



Quinidine - correct answer ✔is a naturally occurring drug for the treatment of arrhythmia



Antibiotics - correct answer ✔Aminoglycosides

Vancomycin

Chloramphenicol