NURS6630 ///NURS 6630
PSYCHOPHARMACOLOGY MIDTERM
EXAM 2 QUESTIONS AND ANSWERS
GRADED A+ 2026
Serotonin regulates - ANS Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of
serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors -
ANS SSRIs
First line therapy for MDD due to milder side effect profiles - ANS SSRIs
Six Common SSRIs - ANS citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline,
paroxetine
Onset of therapeutic benefit from SSRIs - ANS 4-6 weeks
In addition to MDD, SSRIs also treat - ANS Chronic Anxiety, PTSD, OCD, and eating disorders
(bulimia)
Five Common side effects of SSRIs include - ANS Anxiety, insomnia, GI distress, sexual
dysfunction (ED), SIADH
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 1
,Severe side effect of SSRIs in children/adolescents under age 25 years old - ANS suicidal
ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other
serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - ANS Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
ANS Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - ANS Flushing, hyperthermia, agitation, muscle
rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome - ANS Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by - ANS blocking 5-HT2 receptors (serotonin
antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
ANS Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - ANS Prolonged QT interval (normal=0.4.-0.44
seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
ANS Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - ANS C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - ANS fluoxetine, fluvoxamine,
and paroxetine
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 2
, Five common SNRIs include - ANS duloxetine, venlafaxine, desvenlafaxine, milnacipran,
levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and NET to
inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the
synaptic cleft - ANS SNRIs
In addition to MDD SNRIs treat - ANS Anxiety and neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine: - ANS urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - ANS social anxiety, panic disorders, PTSD,
OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - ANS Insomnia, nausea, sexual dysfunction,
hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - ANS suicidal
ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other
serotonergic drugs: - ANS Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - ANS venlafaxine
This SNRI is hepatotoxic: - ANS duloxetine
MAOIs increase the levels of: - ANS Serotonin, Norepinephrine, and Dopamine
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 3
PSYCHOPHARMACOLOGY MIDTERM
EXAM 2 QUESTIONS AND ANSWERS
GRADED A+ 2026
Serotonin regulates - ANS Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of
serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors -
ANS SSRIs
First line therapy for MDD due to milder side effect profiles - ANS SSRIs
Six Common SSRIs - ANS citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline,
paroxetine
Onset of therapeutic benefit from SSRIs - ANS 4-6 weeks
In addition to MDD, SSRIs also treat - ANS Chronic Anxiety, PTSD, OCD, and eating disorders
(bulimia)
Five Common side effects of SSRIs include - ANS Anxiety, insomnia, GI distress, sexual
dysfunction (ED), SIADH
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 1
,Severe side effect of SSRIs in children/adolescents under age 25 years old - ANS suicidal
ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other
serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - ANS Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
ANS Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - ANS Flushing, hyperthermia, agitation, muscle
rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome - ANS Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by - ANS blocking 5-HT2 receptors (serotonin
antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
ANS Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - ANS Prolonged QT interval (normal=0.4.-0.44
seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
ANS Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - ANS C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - ANS fluoxetine, fluvoxamine,
and paroxetine
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 2
, Five common SNRIs include - ANS duloxetine, venlafaxine, desvenlafaxine, milnacipran,
levomilnacipran
This antidepressant class of medications works by binding to presynaptic SERT and NET to
inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the
synaptic cleft - ANS SNRIs
In addition to MDD SNRIs treat - ANS Anxiety and neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine: - ANS urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - ANS social anxiety, panic disorders, PTSD,
OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - ANS Insomnia, nausea, sexual dysfunction,
hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - ANS suicidal
ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other
serotonergic drugs: - ANS Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - ANS venlafaxine
This SNRI is hepatotoxic: - ANS duloxetine
MAOIs increase the levels of: - ANS Serotonin, Norepinephrine, and Dopamine
@COPYRIGHT 2026/2027 ALLRIGHTS RESERVED 3
