D027 WGU
Pathopharm
– Q&A
Celiac Disease
Q: What is the gold standard test for diagnosing celiac disease?
A: Endoscopy with small intestine biopsy
Q: Which antibody is elevated in celiac disease?
A: IgA
Oncology / Genetics
Q: A lung cancer patient is treated with osimertinib (Tagrisso). What mutation is present?
A: EGFR mutation
Musculoskeletal / Genetic Disorders
Page 1 of 112 3/18/2026, 6:24:26 PM
, Q: Progressive muscle weakness with toe walking since childhood suggests what condition?
A: Becker muscular dystrophy
Autoimmune Disorders
Q: How does SLE contribute to thrombocytopenia?
A: It disrupts immune regulation and produces autoantibodies
Hematology / Liver
Q: What is the next step for asymptomatic elevated ferritin?
A: Order liver function tests
Cardiovascular
Q: Irregular heart rate of 130 bpm most likely indicates?
A: Atrial fibrillation requiring rate control
Q: What condition leads to decreased cardiac contractility?
A: Acute myocardial infarction
Endocrine / Metabolic
Q: What condition is characterized by hyperglycemia, ketones, and acidosis?
A: Diabetic ketoacidosis
Q: What lab finding is seen in Cushing disease?
A: Increased cortisol
Respiratory
Q: Shortness of breath when lying down suggests what condition?
A: Asthma
Pediatrics
Q: Barking cough with stridor in a child indicates treatment with?
A: Oral steroids and breathing treatments
Infectious / Acute Care
Q: Delirium, fever, and incontinence require which tests?
A: CBC, CMP, and urinalysis
Page 2 of 112 3/18/2026, 6:24:26 PM
, Neurology / Trauma
Q: Bleeding between skull and dura is called?
A: Epidural hematoma
Gastrointestinal
Q: Likely diagnosis with chronic GI inflammation?
A: Crohn’s disease
Q: Appropriate imaging for abdominal evaluation?
A: Ultrasound
Diabetes / Pharmacology
Q: Which medication reduces cardiovascular risk in type 2 diabetes?
A: Canagliflozin (Invokana)
Preventive Care
Q: Recommended aspirin regimen in elderly patient?
A: 81 mg enteric-coated daily
Thyroid
Q: Elevated TSH (5.31 mIU/L) suggests?
A: Hypothyroidism
Coagulation
Q: DVT in Cushing syndrome is linked to?
A: Increased von Willebrand factor
Pharmacology / Respiratory
Q: What effect does metoprolol have in asthma?
A: Worsens asthma but improves arrhythmias
Q: Long-acting asthma inhaler?
A: Fluticasone/salmeterol (Advair)
Neuropathy
Q: First-line treatment for diabetic neuropathy?
A: Pregabalin (Lyrica)
Neurology
Page 3 of 112 3/18/2026, 6:24:26 PM
, Q: Antipsychotics worsen Parkinson’s because they?
A: Block dopamine
Pregnancy
Q: Safe pain medication during pregnancy?
A: Acetaminophen
Pharmacokinetics
Q: Liver failure affects which drug phase?
A: Metabolism
Hematology
Q: What should patients with G6PD deficiency avoid?
A: Oxidative drugs (acetaminophen is safe)
Anticoagulation
Q: Warfarin dosing is guided by?
A: INR (goal ~2–3)
Genetic Disorders
Q: Medication contraindicated in beta thalassemia?
A: Iron supplements
Pediatrics / Infection
Q: How to administer nystatin to infants?
A: Swab affected areas
Vaccines
Q: Hepatitis B schedule for infants?
A: Birth, 2 months, 6 months
Infant Conditions
Page 4 of 112 3/18/2026, 6:24:26 PM
Pathopharm
– Q&A
Celiac Disease
Q: What is the gold standard test for diagnosing celiac disease?
A: Endoscopy with small intestine biopsy
Q: Which antibody is elevated in celiac disease?
A: IgA
Oncology / Genetics
Q: A lung cancer patient is treated with osimertinib (Tagrisso). What mutation is present?
A: EGFR mutation
Musculoskeletal / Genetic Disorders
Page 1 of 112 3/18/2026, 6:24:26 PM
, Q: Progressive muscle weakness with toe walking since childhood suggests what condition?
A: Becker muscular dystrophy
Autoimmune Disorders
Q: How does SLE contribute to thrombocytopenia?
A: It disrupts immune regulation and produces autoantibodies
Hematology / Liver
Q: What is the next step for asymptomatic elevated ferritin?
A: Order liver function tests
Cardiovascular
Q: Irregular heart rate of 130 bpm most likely indicates?
A: Atrial fibrillation requiring rate control
Q: What condition leads to decreased cardiac contractility?
A: Acute myocardial infarction
Endocrine / Metabolic
Q: What condition is characterized by hyperglycemia, ketones, and acidosis?
A: Diabetic ketoacidosis
Q: What lab finding is seen in Cushing disease?
A: Increased cortisol
Respiratory
Q: Shortness of breath when lying down suggests what condition?
A: Asthma
Pediatrics
Q: Barking cough with stridor in a child indicates treatment with?
A: Oral steroids and breathing treatments
Infectious / Acute Care
Q: Delirium, fever, and incontinence require which tests?
A: CBC, CMP, and urinalysis
Page 2 of 112 3/18/2026, 6:24:26 PM
, Neurology / Trauma
Q: Bleeding between skull and dura is called?
A: Epidural hematoma
Gastrointestinal
Q: Likely diagnosis with chronic GI inflammation?
A: Crohn’s disease
Q: Appropriate imaging for abdominal evaluation?
A: Ultrasound
Diabetes / Pharmacology
Q: Which medication reduces cardiovascular risk in type 2 diabetes?
A: Canagliflozin (Invokana)
Preventive Care
Q: Recommended aspirin regimen in elderly patient?
A: 81 mg enteric-coated daily
Thyroid
Q: Elevated TSH (5.31 mIU/L) suggests?
A: Hypothyroidism
Coagulation
Q: DVT in Cushing syndrome is linked to?
A: Increased von Willebrand factor
Pharmacology / Respiratory
Q: What effect does metoprolol have in asthma?
A: Worsens asthma but improves arrhythmias
Q: Long-acting asthma inhaler?
A: Fluticasone/salmeterol (Advair)
Neuropathy
Q: First-line treatment for diabetic neuropathy?
A: Pregabalin (Lyrica)
Neurology
Page 3 of 112 3/18/2026, 6:24:26 PM
, Q: Antipsychotics worsen Parkinson’s because they?
A: Block dopamine
Pregnancy
Q: Safe pain medication during pregnancy?
A: Acetaminophen
Pharmacokinetics
Q: Liver failure affects which drug phase?
A: Metabolism
Hematology
Q: What should patients with G6PD deficiency avoid?
A: Oxidative drugs (acetaminophen is safe)
Anticoagulation
Q: Warfarin dosing is guided by?
A: INR (goal ~2–3)
Genetic Disorders
Q: Medication contraindicated in beta thalassemia?
A: Iron supplements
Pediatrics / Infection
Q: How to administer nystatin to infants?
A: Swab affected areas
Vaccines
Q: Hepatitis B schedule for infants?
A: Birth, 2 months, 6 months
Infant Conditions
Page 4 of 112 3/18/2026, 6:24:26 PM
