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CMSRN Medical-Surgical Nursing Exam (2026) – 200 Questions on Med-Surg, Pharmacology, Neuro & GI

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This document contains approximately 200 multiple-choice questions with verified answers for the CMSRN Medical-Surgical Nursing Certification Exam 2026 . It provides a comprehensive and in-depth review of adult health nursing concepts, focusing on pathophysiology, pharmacology, clinical decision-making, and priority-based patient care. As shown on page 1, the document begins with foundational medical-surgical concepts such as ascites and its association with low plasma albumin levels, reflecting fluid imbalance and liver dysfunction. Early sections (pages 2–10) cover respiratory conditions (e.g., foreign body aspiration, oxygen therapy), infectious diseases (e.g., MRSA, hepatitis), and diagnostic procedures (e.g., CT scans, ultrasound, endoscopy). These sections also integrate pharmacological considerations, including oxygen humidification and medication-related interventions. The middle sections (pages 10–25) focus on complex systemic disorders such as sickle cell disease (nitric oxide depletion), diabetic ketoacidosis, pulmonary embolism (D-dimer interpretation), and post-operative complications (e.g., the “5 W’s” of fever). Neurological concepts are also emphasized, including intracranial pressure (normal ~15 mmHg), Glasgow Coma Scale prioritization, and emergency interventions such as airway management. Cardiovascular and hematologic topics include atrial fibrillation management (digoxin), clot formation (Virchow’s triad), and complications like fat embolism. Later sections (pages 25–37) expand into endocrine, gastrointestinal, and genitourinary conditions, including diabetes management, GERD positioning (reverse Trendelenburg), gout dietary considerations, and reproductive health topics. It also includes pharmacologic safety (e.g., warfarin bleeding signs), emergency care (anaphylaxis treatment), and patient education strategies. Clinical scenarios throughout the document reinforce prioritization, safety, and evidence-based nursing interventions. The structured Q&A format mirrors CMSRN certification exams, combining theoretical knowledge with real clinical scenarios. It supports critical thinking, prioritization skills, and exam readiness for medical-surgical nursing practice. This document is ideal for: CMSRN certification candidates Medical-surgical nursing students and practicing nurses NCLEX-RN candidates and review students Nursing professionals seeking clinical knowledge reinforcement The content aligns closely with Brunner & Suddarth’s Textbook of Medical-Surgical Nursing and CMSRN exam preparation resources widely used in nursing education. Keywords: CMSRN exam questions, medical surgical nursing test, adult health nursing, pathophysiology nursing, pharmacology nursing, ascites hypoalbuminemia, pulmonary embolism D dimer, diabetic ketoacidosis nursing, sickle cell disease management, intracranial pressure nursing, postoperative complications 5 Ws, GERD positioning nursing, warfarin side effects bleeding, nursing clinical decision making

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Practice CMSRN Test Bank 2026
Exam Questions and Verified
Answers | Already Graded A+



A patient has Ascites. What is a sign of Ascites?




A. High Epinephrine Levels

B. Low Plasma Albumin levels

C. High Plasma Oncotic levels

,D. Low Blood PRessure - 🧠 ANSWER ✔✔B. Low Plasma Albumin levels.

The lack of pressure from plasma proteins will allow fluid to enter the wrong

areas. Cirrhosis may develop in some cases.

What makes Ca-MRSA unique compared to other types of MRSA?




A. A. It is acquired in a hospital

B. It is transmitted through sex

C. It is transmitted through blood transfusions


D. All of the above - 🧠 ANSWER ✔✔A. IT is acquired in a hospital.

Community-acquired MRSA usually 48 hours before admission

Foreign body aspiration entails an object in the:




A. Larynx

B. Trachea

C. Both A and B


D. Neither A nor B - 🧠 ANSWER ✔✔C. Both A and B. An object in the

larynx or trachea blocking the airway.

,A patient requires supplemental oxygen for a pulmonary treatment. Which

of the following is correct about the oxygen that must be administered?




A. The oxygen must be consistent

B. The pressure should be high

C. The pressure should be low


D. The oxygen must be fully humidified - 🧠 ANSWER ✔✔D. The oxygen

must be fully humidified. The humidification will allow the oxygen to

circulate throughout the body.

What scan may help with identifying a case of appendicitis?




A. An Ultrasound

B. A CT Scan

C. An MRI


D. All of the Above - 🧠 ANSWER ✔✔A. An ultrasound.


What is one true factor about peptic ulcer disease?



COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED

, A. Stomach pain starts 30 min after eating?

B. Malignant tumors may develop

C. An endoscopy is needed


D. NSAID use may be a concern - 🧠 ANSWER ✔✔C. An endoscopy is

needed to diagnose peptic ulcer disease. It will take a few hours for

stomach pain to develop

A person has sickle cell disease. Which of the following is a correct

statement based on his or her medical condition?




A. The person has less free hemoglobin

B. Nitric oxide totals will drop

C. Arterial pressure may change


D. Sildenafil may resolve blood-related concerns - 🧠 ANSWER ✔✔B. Nitric

oxide totals will drop. This is due to the sickle cell disease, Hemolysis will

develop and free hemoglobin will increase due to the unusual shapes of the

blood cells

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