COMPREHENSIVE TEST PAPER QUESTIONS
WITH VERIFIED ANSWERS
◉ Ergot Alkaloids and dihydroergotamine. Answer: 2nd line therapy
after 1st doesnt work
◉ Pramipexole can cause. Answer: sleep attacks (overwhelming and
irresistible sleepiness)
◉ screening before pramipexol prescribing. Answer: compulsive
behaviors
◉ Parkinsons disease. Answer: underlying cause of motor symptoms
is loss of dopaminergic neurons in the substantia nigra
◉ cardinal symptoms PD. Answer: resting tremor, rigidity, postural
instability, slowed movement
◉ Levodopa. Answer: most effective med for Parkinsons
, ◉ Additions to levodopa. Answer: dopamine agonists, MAOB
inhibitors, COMT inhibitors, Amantadine and anticholinergics
◉ Amantadine (symmetrel). Answer: NMDA receptor antagonist.
Effective as monotherapy and adjunct therapy for off times and
dyskinesia
◉ Gocovir. Answer: extended release amantadine. Used for
dyskinesias
◉ Benztropine (Cogentin). Answer: minimizes resting tremor and
drooling but not as efficacious as other meds in treating rigidity,
bradykinesia and gait problems
◉ Rivastigimine (Exelon) transdermal patch. Answer: used for
dementia associated with parkinsons disease
◉ Alzheimers disease. Answer: progressive memory loss and
decreased brain function from protein deposits in the brain
impairing function of neurons causing them to lose connection with
other brain cells and die
◉ major pathologic findings. Answer: cerebral atrophy, degeneration
of cholinergic neurons, neuritic plaques and neurofibrillary tangles