PCB 3233
PCB 3233 EXAM 6 STUDY GUIDE UCF
GRADED A+ 2026
Order complement pathways are activated
Alt > lectin > classical
Integrins bind to
Ig superfamily protiens
Most abundant leukocyte IN BLOOD
Neutrophils
How long to develop primary adaptive immune response
7-14 days
Successful rearrangement of the α-chain locus leads to:
Deletion of delta chain locus
What cell activates naive T cells
Dendritic cell
Soluble C convertase in alternative pathway
Ic3bb
Receptors on macrophages responsible for cytokine creation/secretion
Toll-like
Antibody structure
2 Fabs and 1 Fc
Wherer are T cell B cell conjugate pairs formed
T cell-B cell border
Affinity
Tightness of binding of binding site to antigen
PCB 3233
,PCB 3233
Avidity
The firmness of association between multideterminant antigen and the antibodies
produced against it.
Extravasation steps
1. Rolling adhesion
2. Tight binding
3. Diapedesis
4. Migration
Commensal species
Do not cause harm to host
The main opsonin placed on pathogen surface
C3b
First barrier against infection
Skin + mucosal surfaces
Least abundant leukocyte
Basophil
T-cell receptors
Are highly specific
Anaphylotoxins
C3a, c4a, c5a
What cell types do not express MHC class I
Erythocytes
Jenner used the vaccinia virus (cowpox) to induce immunity against the
Variola virus (smallpox)
Zymogen in the alternative pathway
Factor B
CR3 is a PRR that recognizes
PCB 3233
, PCB 3233
Pamps (Ex. LPS)
Macrophages
- reside within the tissues
- are one of the first effector cells to encounter new infection
- function in innate or adaptive reponse
CR-1 can
Induce phagocytosis by binding to c3b
How many CDRS and hvs are in a single FAB
3 CDR (6 whole)
3 HV (6 whole)
Degradation of extracellular proteins
Peptides produced will be found in phagolysosome
First check point in B cell maturation
Involves a pre-BCR
Pre-BCR
Heavy chain, surrogate light chain, vpreb
Where do B cells develop
Primary LT and bone marrow
Fdcs
Found in light zone of GC, hold antigen for B cell to bind to
What competes to gain access to antigen on FDC
Centrocytes
Antibodies
- bind with high specificity and affinity
- produced by B cells in response to infection
- circulate has major component of plasma in blood and lymph
Most common antibody found in secretions
PCB 3233
PCB 3233 EXAM 6 STUDY GUIDE UCF
GRADED A+ 2026
Order complement pathways are activated
Alt > lectin > classical
Integrins bind to
Ig superfamily protiens
Most abundant leukocyte IN BLOOD
Neutrophils
How long to develop primary adaptive immune response
7-14 days
Successful rearrangement of the α-chain locus leads to:
Deletion of delta chain locus
What cell activates naive T cells
Dendritic cell
Soluble C convertase in alternative pathway
Ic3bb
Receptors on macrophages responsible for cytokine creation/secretion
Toll-like
Antibody structure
2 Fabs and 1 Fc
Wherer are T cell B cell conjugate pairs formed
T cell-B cell border
Affinity
Tightness of binding of binding site to antigen
PCB 3233
,PCB 3233
Avidity
The firmness of association between multideterminant antigen and the antibodies
produced against it.
Extravasation steps
1. Rolling adhesion
2. Tight binding
3. Diapedesis
4. Migration
Commensal species
Do not cause harm to host
The main opsonin placed on pathogen surface
C3b
First barrier against infection
Skin + mucosal surfaces
Least abundant leukocyte
Basophil
T-cell receptors
Are highly specific
Anaphylotoxins
C3a, c4a, c5a
What cell types do not express MHC class I
Erythocytes
Jenner used the vaccinia virus (cowpox) to induce immunity against the
Variola virus (smallpox)
Zymogen in the alternative pathway
Factor B
CR3 is a PRR that recognizes
PCB 3233
, PCB 3233
Pamps (Ex. LPS)
Macrophages
- reside within the tissues
- are one of the first effector cells to encounter new infection
- function in innate or adaptive reponse
CR-1 can
Induce phagocytosis by binding to c3b
How many CDRS and hvs are in a single FAB
3 CDR (6 whole)
3 HV (6 whole)
Degradation of extracellular proteins
Peptides produced will be found in phagolysosome
First check point in B cell maturation
Involves a pre-BCR
Pre-BCR
Heavy chain, surrogate light chain, vpreb
Where do B cells develop
Primary LT and bone marrow
Fdcs
Found in light zone of GC, hold antigen for B cell to bind to
What competes to gain access to antigen on FDC
Centrocytes
Antibodies
- bind with high specificity and affinity
- produced by B cells in response to infection
- circulate has major component of plasma in blood and lymph
Most common antibody found in secretions
PCB 3233
