Inflammatory Bowel Disease: Crohn's Disease vs. Ulcerative Colitis

Inflammatory Bowel Disease

Q1: What are the key differences in the distribution of inflammation between Crohn's
Disease and Ulcerative Colitis?
A1:
| Feature | Crohn's Disease | Ulcerative Colitis

| Distribution | Patchy, transmural, skip lesions | Continuous, mucosal, no skip lesions |

| Location | Mouth to anus (ileum most common)

| Colon & rectum (proctitis, left-sided, pancolitis) |

| Rectal involvement | Less common (20%) | Always involved (100%) |

| Depth of inflammation | Transmural (full thickness) | Mucosal (limited to mucosa &
submucosa) |

Q2: What are the common extraintestinal manifestations of IBD?
A2:
- *Joints*: arthritis (10-20%), ankylosing spondylitis (2-6%)
- *Eyes*: uveitis (2-5%), episcleritis
- *Skin*: erythema nodosum (10-15%), pyoderma gangrenosum (1-2%)
- *Liver*: primary sclerosing cholangitis (5-10%)
- *Other*: osteoporosis, anemia, thromboembolism

Q3: How do the symptoms of Crohn's Disease and Ulcerative Colitis differ?
A3:
- *Crohn's*:
- Abdominal pain (RLQ > LLQ)
- Diarrhea (non-bloody)
- Weight loss
- Fatigue
- Fistulas, abscesses

- *Ulcerative Colitis*:
- Bloody diarrhea
- Urgency
- Tenesmus
- Rectal pain

GI Cancers
Q4: What are the risk factors for colorectal cancer?
A4:
- *Age >50*