QUESTIONS AND PRACTICE SOLUTION
GRADED A+
◉ Allylamines: terbinafine (Lamisil) - Adverse Effects. Answer: GI
upset, Skin reactions, Altered taste, Hepatotoxicity
◉ Allylamines: terbinafine (Lamisil) - Precautions. Answer: Hepatic
disease
◉ Allylamines: terbinafine (Lamisil) - Interactions. Answer:
Rifampin, cimetidine, fluconazole, ketoconazole, amiodarone,
caffeine, tricyclic antidepressants, SSRIs, and beta-blockers
◉ Allylamines: terbinafine (Lamisil) - Education. Answer: Oral or
topical
◉ Allylamines: terbinafine (Lamisil) - Labs. Answer: LFTs
◉ Polyene: nystatin (Mycostatin). Answer: Antifungal: Candidiasis
◉ Polyene: nystatin (Mycostatin) - Mechanism of Action. Answer:
forms pores in the fungal cell wall by binding to ergosterol.
,◉ Polyene: nystatin (Mycostatin) - Adverse Effects. Answer: GI
upset, Local irritation
◉ Polyene: nystatin (Mycostatin) - Precautions. Answer: Systemic
mycoses
◉ acyclovir (Zovirax). Answer: Antiviral: Herpes, Varicella,
Cytomegalovirus
◉ acyclovir (Zovirax) - Mechanism of Action. Answer: Inhibits viral
DNA synthesis by undergoing activation to acyclo− GMP via the
thymidine kinase enzyme. GMP is then converted to acyclo−GTP
which then inhibits viral DNA polymerase and gets incorporated into
viral DNA, blocking further DNA chain growth.
◉ acyclovir (Zovirax) - Adverse Effects. Answer: Infusion site
reactions, Nephrotoxicity, CNS effects, GI upset
◉ acyclovir (Zovirax) - Precautions. Answer: Renal Impairment
◉ acyclovir (Zovirax) - Interactions. Answer: Nephrotoxic meds
◉ acyclovir (Zovirax) - Education. Answer: Topical, Oral, or IV
, ◉ acyclovir (Zovirax) - Labs. Answer: BMP
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu). Answer:
Antiviral: Influenza
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu) - Mechanism of
Action. Answer: inhibits the neuraminidase enzyme on the surface of
the influenza virus. This inhibition prevents the release of new viral
particles from infected cells, effectively halting the spread of
infection within the body.
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu) - Adverse Effects.
Answer: Hypersensitivity, CNS effects, GI upset
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu) - Precautions.
Answer: Immediate treatment initiation
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu) - Interactions.
Answer: Live flu vaccine
◉ Neuraminidase Inhibitor: oseltamivir (Tamiflu) - Education.
Answer: Oral, take with food, annual vaccination