ADVANCED PATHOPHYSIOLOGY EXAM 1 || MOST
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A 61-year-old male client is scheduled to begin
chemotherapy for the treatment of his bone cancer shortly.
Staff at the cancer center have educated the man and his
wife about the goals, course, and expectations of his
treatment. Which of the following medications and
treatments might the man anticipate needing during and
after his course of treatment?
-Analgesia and corticosteroids
-Antiemetics and packed red blood cell (PRBC)
transfusions
-Whole blood transfusion and antiplatelet aggregators
-Diuretics and selective serotonin reuptake inhibitors
(SSRIs) - Answer--Antiemetics and packed red blood cell
(PRBC) transfusions
As part of a screening program for prostate cancer, men at
a senior citizen's center are having their blood levels of
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prostate-specific antigen (PSA) measured. Which of the
following statements would best characterize high positive
predictive value but low negative predictive value for this
screening test?
-All of the men who had high PSA levels developed
prostate cancer; several men who had low PSA levels also
developed prostate cancer.
-All of the men who had low PSA levels were cancer-free;
several men who had high levels also remained free of
prostate cancer.
-Men who had low PSA levels also displayed false positive
results for prostate cancer; men with high levels were
often falsely diagnosed with prostate cancer.
-The test displayed low sensitivity but high specificity. -
Answer--All of the men who had high PSA levels
developed prostate cancer; several men who had low PSA
levels also developed prostate cancer.
A patient has been diagnosed with a neurodegenerative
disease called multiple sclerosis (MS). The physician
explains to the patient that this disease may be caused by
dysregulated apoptosis. Later that day, the patient asks
the nurse what this means. The NP should reply:
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-The cells around your nerves don't know how to die
correctly.
-The cytoplasm should neutralize the various apoptotic
inhibitors but isn't working correctly.
-Dysregulated apoptosis has caused an excessive rate of
programmed cell death along the neuro-pathways.
-There is an inappropriately low rate of apoptosis
occurring within the cells. - Answer--Dysregulated
apoptosis has caused an excessive rate of programmed
cell death along the neuro-pathways.
During a crime scene investigation, the coroner confirms
that rigor mortis has set in. This helps to confirm an
approximate time of death. The forensic nurse can explain
this process (rigor mortis) to a group of students based on
the fact that:
-Troponin is being prevented from forming a cross-bridge
between the actin and myosin.
-The activated by ATP, cross-bridges become attached to
the actin filament.
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-The myosin head catalyzes the breakdown of ATP to
provide the energy need so that a cross-bridge can be
formed.
-At death, the body is unable to complete the actin/myosin
cycle and release the coupling between the myosin and
actin, creating a state of muscular contraction - Answer--At
death, the body is unable to complete the actin/myosin
cycle and release the coupling between the myosin and
actin, creating a state of muscular contraction
A member of the health care team is researching the
etiology and pathogenesis of a number of clients who are
under his care in a hospital context. Which of the following
aspects of clients' situations best characterizes
pathogenesis rather than etiology?
-A client who has been exposed to the mycobacterium
tuberculosis bacterium
-A client who has increasing serum ammonia levels due to
liver cirrhosis
-A client who was admitted with the effects of methyl
alcohol poisoning
-A client with multiple skeletal injuries secondary to a
motor vehicle accident - Answer-A client who has
increasing serum ammonia levels due to liver cirrhosis