NRNP 6566 WK1-5 Midterm Exam Questions &
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Terms in this set (38)
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes
used to metabolize medications
Inhibitors block metabolic activity from one or more
CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing
enzyme synthesis
Describe effect on low and high Albumin is the plasma protein with the greatest
albumin levels on active drug levels capacity for binding drugs. Binding plasma
especially for drugs that are highly proteins affect drug distribution into tissues,
protein bound because only drug that is not bound is available
to penetrate tissues, bind to receptors, and exert
activity. As free drug leaves the blood stream,
more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
Highly protein bound drugs can toxicity in patients with low albumin levels,
lead to example malnutrition or chronic illness. This is
because there are fewer than the normal sites for
the drug to bind
, Describe the ways the hepatic first Alternative routes include:
pass effect- which is metabolism suppository
during first pass through the liver intravenous
intramuscular
inhalational aerosol
transdermal
sublingual
These allow drugs to bypass the first-pass effect
and be absorbed directly into systemic
circulation
Be able to calculate creatinine Male = 140-age times weight in kilograms divided
clearance using Cockgraft Gault by serum creatinine times 72.
equation: Women = CRCL (male) times 0.85
Describe what determines the half life
frequency of drug administration plasma concentration
Be familiar with the beers criteria Potentially Inappropriate Medication Use in
and how to use it Older Adults
to call attention to medications that are most
commonly problematic and thus should be
avoided in older adults
Describe factors that affect low blood state (shock or arrest), contact time
absorption with GI tract too fast (diarrhea = cant absorb),
delayed stomach emptying (large meal = delayed
absorption)Drug- to drug or drug to food
interactions
Describe the factors that affect low albumin levels, body composition, cardiac
distribution decompensation (heart failure), age
Describe the factors that affect genetics, age, organ function
metabolism
Answers | 100% Verified solutions |Questions
with Correct Answers 2026 latest update!!
Save
Terms in this set (38)
Describe cytochrome p450 system Cytochrome p450 system is a series of enzymes
used to metabolize medications
Inhibitors block metabolic activity from one or more
CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing
enzyme synthesis
Describe effect on low and high Albumin is the plasma protein with the greatest
albumin levels on active drug levels capacity for binding drugs. Binding plasma
especially for drugs that are highly proteins affect drug distribution into tissues,
protein bound because only drug that is not bound is available
to penetrate tissues, bind to receptors, and exert
activity. As free drug leaves the blood stream,
more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
Highly protein bound drugs can toxicity in patients with low albumin levels,
lead to example malnutrition or chronic illness. This is
because there are fewer than the normal sites for
the drug to bind
, Describe the ways the hepatic first Alternative routes include:
pass effect- which is metabolism suppository
during first pass through the liver intravenous
intramuscular
inhalational aerosol
transdermal
sublingual
These allow drugs to bypass the first-pass effect
and be absorbed directly into systemic
circulation
Be able to calculate creatinine Male = 140-age times weight in kilograms divided
clearance using Cockgraft Gault by serum creatinine times 72.
equation: Women = CRCL (male) times 0.85
Describe what determines the half life
frequency of drug administration plasma concentration
Be familiar with the beers criteria Potentially Inappropriate Medication Use in
and how to use it Older Adults
to call attention to medications that are most
commonly problematic and thus should be
avoided in older adults
Describe factors that affect low blood state (shock or arrest), contact time
absorption with GI tract too fast (diarrhea = cant absorb),
delayed stomach emptying (large meal = delayed
absorption)Drug- to drug or drug to food
interactions
Describe the factors that affect low albumin levels, body composition, cardiac
distribution decompensation (heart failure), age
Describe the factors that affect genetics, age, organ function
metabolism
