APHON PRINCIPLES OF CHEMO AND
BIOTHERAPY EXAM WITH CORRECT
ACTUAL QUESTIONS AND CORRECTLY
WELL DEFINED ANSWERS LATEST
ALREADY GRADED A+
6 cell characteristics of malignant cells in easier terms -
ANSWERS-Mutated DNA alters instructions for function 2.
Parasitic to host and has no beneficial function 3.
Uncontrolled reproduction 4. Invades surrounding tissues
and mets 5. Immortal 6. Call birth is greater then cell death
6 mechanisms of drug resistance by the cell - ANSWERS-1.
Decreased drug uptake by the cell 2. Increased removal of
the drug out of the cell r/t changes in the cell membrane 3.
Detoxification of the drug in the cell r/t metabolic changes
4. Increased repair of DNA 5. Alterations in the structure of
drug receptor sites 6. Decreased sensitivity to apoptosis.
MDR1 - ANSWERS-Multidrug resistance gene 1. May occur
prior to exposure of chemo or after. Caused by the presence
of P-glycoprotein
, How should chemo be administered to maximize
effectiveness? - ANSWERS-At the maximum tolerated doses
with the shortest possible interval
What are chemotherapy effects on the cell cycle with cell
cycle specific drugs? - ANSWERS-1. Greatest effect on
actively dividing cells 2. NOT active in G0 phase 3. Greatest
action in divided doses or continuous infusion 4. Cytotoxic
effects occur when cell repair or division is attmepted
What are Chemotherapy effects on the cell cycle with cell
cycle non-specific drugs? - ANSWERS-1. Work in any cell
phase (even in G0) 2. Greatest action when administered as
a bolus 3. Cytotoxic effects occur when cell division is
attempted
What chemo agents causes damage or interference with
DNA? - ANSWERS-Antimetabolites, alkylating agents, anti
tumor antibiotics, nitrosureas
What chemo agent causes cell cycle phase arrest? -
ANSWERS-Plant alkaloids
BIOTHERAPY EXAM WITH CORRECT
ACTUAL QUESTIONS AND CORRECTLY
WELL DEFINED ANSWERS LATEST
ALREADY GRADED A+
6 cell characteristics of malignant cells in easier terms -
ANSWERS-Mutated DNA alters instructions for function 2.
Parasitic to host and has no beneficial function 3.
Uncontrolled reproduction 4. Invades surrounding tissues
and mets 5. Immortal 6. Call birth is greater then cell death
6 mechanisms of drug resistance by the cell - ANSWERS-1.
Decreased drug uptake by the cell 2. Increased removal of
the drug out of the cell r/t changes in the cell membrane 3.
Detoxification of the drug in the cell r/t metabolic changes
4. Increased repair of DNA 5. Alterations in the structure of
drug receptor sites 6. Decreased sensitivity to apoptosis.
MDR1 - ANSWERS-Multidrug resistance gene 1. May occur
prior to exposure of chemo or after. Caused by the presence
of P-glycoprotein
, How should chemo be administered to maximize
effectiveness? - ANSWERS-At the maximum tolerated doses
with the shortest possible interval
What are chemotherapy effects on the cell cycle with cell
cycle specific drugs? - ANSWERS-1. Greatest effect on
actively dividing cells 2. NOT active in G0 phase 3. Greatest
action in divided doses or continuous infusion 4. Cytotoxic
effects occur when cell repair or division is attmepted
What are Chemotherapy effects on the cell cycle with cell
cycle non-specific drugs? - ANSWERS-1. Work in any cell
phase (even in G0) 2. Greatest action when administered as
a bolus 3. Cytotoxic effects occur when cell division is
attempted
What chemo agents causes damage or interference with
DNA? - ANSWERS-Antimetabolites, alkylating agents, anti
tumor antibiotics, nitrosureas
What chemo agent causes cell cycle phase arrest? -
ANSWERS-Plant alkaloids
