PHAR1101 UWA Questions with Complete Solutions 100% Correct
1. Pharmodynam- what the drug does to the body
ics
2. Pharmacokinet- what the body does to the drug
ics
3. Four fundamen- Absorption, distribution, metabolism, excretion
tal pharmaco-
logical processes
when taking a
drug
4. MTC minimum toxic concentration
5. MEC minimum ettective concentration
6. Bioavaliability Fraction of the drug dose reaching the systemic circulation after ingestion.
7. Reasons for Drug is too big (>600g/mol)
bioavailability Not Greasy Enough (too hydrophilic)
-Need to be more lipophilic to cross lipid rich cell membrane.
Drug Carries a charge (ionised). Only neutral molecules can cross lipid mem-
branes.
Drug is metabolised in the gut wall (MOST SIGNIFICANT)
Drug is pumped back into gut "membrane transporters"
8. Octanol Water partitioning. Assesses solubility of a drug in a simple 2 phase system.
Solution of water and Octanol where the octanol floats on water. Add drugs, mix
and settle.
Lipophilic: drugs go into the octanol
Hydrophilic: Drugs into water
9. Hydrophilic
1/3
1. Pharmodynam- what the drug does to the body
ics
2. Pharmacokinet- what the body does to the drug
ics
3. Four fundamen- Absorption, distribution, metabolism, excretion
tal pharmaco-
logical processes
when taking a
drug
4. MTC minimum toxic concentration
5. MEC minimum ettective concentration
6. Bioavaliability Fraction of the drug dose reaching the systemic circulation after ingestion.
7. Reasons for Drug is too big (>600g/mol)
bioavailability Not Greasy Enough (too hydrophilic)
-Need to be more lipophilic to cross lipid rich cell membrane.
Drug Carries a charge (ionised). Only neutral molecules can cross lipid mem-
branes.
Drug is metabolised in the gut wall (MOST SIGNIFICANT)
Drug is pumped back into gut "membrane transporters"
8. Octanol Water partitioning. Assesses solubility of a drug in a simple 2 phase system.
Solution of water and Octanol where the octanol floats on water. Add drugs, mix
and settle.
Lipophilic: drugs go into the octanol
Hydrophilic: Drugs into water
9. Hydrophilic
1/3
