PRACTICE QUESTION PART 4 (LMR)
WITH COMPLETE SOLUTIONS16
Which of the following would NOT be a typical methodology for a clinical chemistry test?
Immunoturbidimetry
Microscopy
EMIT®
ISE - ANSWERS-b
How should a laboratory verify the reference range it uses for a particular test?
Call another laboratory
Use the numbers from a textbook
Test samples from healthy people
Look on a medical internet site - ANSWERS-c
ESTABLISHING A REFERENCE INTERVAL
A new reference interval is established when there is no existing analyte or methodology in the
clinical or reference laboratory with which to conduct comparative studies. It is a costly and
labor-intensive study that will involve laboratory resources at all levels and may require from
____ to as many as ≈700 study individuals.
20 study individuals
50 study individuals
,100 study individuals
120 study individuals - ANSWERS-d
VERIFYING a reference interval (transference) is done to confirm the validity of an existing
reference interval for an analyte using the same (identical) type of analytic system (method
and/or instrument). These are the most common reference interval studies performed in the
clinical laboratory and can require as few as ____ study individuals.
20 study individuals
50 study individuals
100 study individuals
120 study individuals - ANSWERS-a
A Gaussian distribution is usually:
Rectangular
Bell-shaped
Uniform
Skewed - ANSWERS-b
Acceptable limits of a control value must fall:
Within ±1 standard deviation of the mean
Between 1 and 2 standard deviations of the mean
Within ±2 standard deviations of the mean
Within ±3 standard deviations of the mean - ANSWERS-c
, Two standard deviations (2 SD) from the mean in a normal distribution curve would include:
99% of all values
95% of all values
75% of all values
68% of all values - ANSWERS-b
Which of the following sets of values for repeat analyses of a QC sample (target value of 50)
reflects the best precision?
50, 51, 52
50, 52, 56
48, 50, 52
44, 50, 53 - ANSWERS-a
What is used to zero the spectrophotometer before reading the test sample?
Calibrator
Sample blank
Reagent blank
Standard - ANSWERS-c
What is used to zero the spectrophotometer During reading the test sample?
Calibrator
Sample blank
WITH COMPLETE SOLUTIONS16
Which of the following would NOT be a typical methodology for a clinical chemistry test?
Immunoturbidimetry
Microscopy
EMIT®
ISE - ANSWERS-b
How should a laboratory verify the reference range it uses for a particular test?
Call another laboratory
Use the numbers from a textbook
Test samples from healthy people
Look on a medical internet site - ANSWERS-c
ESTABLISHING A REFERENCE INTERVAL
A new reference interval is established when there is no existing analyte or methodology in the
clinical or reference laboratory with which to conduct comparative studies. It is a costly and
labor-intensive study that will involve laboratory resources at all levels and may require from
____ to as many as ≈700 study individuals.
20 study individuals
50 study individuals
,100 study individuals
120 study individuals - ANSWERS-d
VERIFYING a reference interval (transference) is done to confirm the validity of an existing
reference interval for an analyte using the same (identical) type of analytic system (method
and/or instrument). These are the most common reference interval studies performed in the
clinical laboratory and can require as few as ____ study individuals.
20 study individuals
50 study individuals
100 study individuals
120 study individuals - ANSWERS-a
A Gaussian distribution is usually:
Rectangular
Bell-shaped
Uniform
Skewed - ANSWERS-b
Acceptable limits of a control value must fall:
Within ±1 standard deviation of the mean
Between 1 and 2 standard deviations of the mean
Within ±2 standard deviations of the mean
Within ±3 standard deviations of the mean - ANSWERS-c
, Two standard deviations (2 SD) from the mean in a normal distribution curve would include:
99% of all values
95% of all values
75% of all values
68% of all values - ANSWERS-b
Which of the following sets of values for repeat analyses of a QC sample (target value of 50)
reflects the best precision?
50, 51, 52
50, 52, 56
48, 50, 52
44, 50, 53 - ANSWERS-a
What is used to zero the spectrophotometer before reading the test sample?
Calibrator
Sample blank
Reagent blank
Standard - ANSWERS-c
What is used to zero the spectrophotometer During reading the test sample?
Calibrator
Sample blank
