Pharmacology (NDEB of Can) || 100% Verified Answers.
Where are amides metabolized? correct answers Liver
Where are esters metabolized? correct answers In the plasma by pseudocholinesterase
4 local anesthetics that are esters: correct answers 1) Procaine 2) Cocaine 3) Benzocaine 4)
Tetracaine (***there is no 'i" before -caine)
Out of the amide anesthetics, which is safest to use in children? correct answers Lidocaine
(xylocaine)
Out of the amide anesthetics, which is unsafe to use in children? correct answers Bupivicaine
What is the percentage of local anesthetic in a bupivicaine carpule? correct answers 0.5%
Which amide local anesthetic causes the least amount of vasodilation? correct answers
Mepivicaine (Carbocaine, Polocaine)
Which amide local anesthetic presents with an ester side chain? correct answers Articaine
(Septocaine)
Which amide local anesthetic is capable of causing methemglobinemia? correct answers
Prilocaine (Citanest)
What percentage of local anethestic is mepivicaine offered in? correct answers 2%, 3%
Which local anesthetic is responsible for vasconstriction? correct answers Cocaine
What is the MOA of local anesthetics? correct answers Sodium channel blocker
, In which form are local anesthetics able to penetrate the neuronal membrane? correct answers
Non-ionized (free base)
What is the impact on duration of action for a local anesthetic that has increased blood flow?
correct answers Shorter duration of action
What is the impact on the potency and duration of action with increased lipid
solubility/hydrophobicity? correct answers More potent and longer duration of action
What is the impact on duration of action with increased protein binding? correct answers Longer
duration of action
What is the impact of a lower pKa on the on set of action? correct answers Faster onset of action
What is the pKa value of mepivicaine? correct answers 7.6
What is the pKa value of lidoacine, articaine, and prilocaine? correct answers 7.1
What is the pKa value of bupivicaine? correct answers 8.1
3 advantages of vascoconstrictor within local anesthetics: correct answers 1) Prolongs numbness
2) Reduces toxicity 3) Promotes hemostasis
What is considered the max epinephrine for an ASA I patient? correct answers 0.2mg
What is considered the max. epinephrine for a cardiac patient? correct answers 0.04 mmg
What is the max lidocaine without vasoconstrictor? correct answers 4.4mg/kg
Where are amides metabolized? correct answers Liver
Where are esters metabolized? correct answers In the plasma by pseudocholinesterase
4 local anesthetics that are esters: correct answers 1) Procaine 2) Cocaine 3) Benzocaine 4)
Tetracaine (***there is no 'i" before -caine)
Out of the amide anesthetics, which is safest to use in children? correct answers Lidocaine
(xylocaine)
Out of the amide anesthetics, which is unsafe to use in children? correct answers Bupivicaine
What is the percentage of local anesthetic in a bupivicaine carpule? correct answers 0.5%
Which amide local anesthetic causes the least amount of vasodilation? correct answers
Mepivicaine (Carbocaine, Polocaine)
Which amide local anesthetic presents with an ester side chain? correct answers Articaine
(Septocaine)
Which amide local anesthetic is capable of causing methemglobinemia? correct answers
Prilocaine (Citanest)
What percentage of local anethestic is mepivicaine offered in? correct answers 2%, 3%
Which local anesthetic is responsible for vasconstriction? correct answers Cocaine
What is the MOA of local anesthetics? correct answers Sodium channel blocker
, In which form are local anesthetics able to penetrate the neuronal membrane? correct answers
Non-ionized (free base)
What is the impact on duration of action for a local anesthetic that has increased blood flow?
correct answers Shorter duration of action
What is the impact on the potency and duration of action with increased lipid
solubility/hydrophobicity? correct answers More potent and longer duration of action
What is the impact on duration of action with increased protein binding? correct answers Longer
duration of action
What is the impact of a lower pKa on the on set of action? correct answers Faster onset of action
What is the pKa value of mepivicaine? correct answers 7.6
What is the pKa value of lidoacine, articaine, and prilocaine? correct answers 7.1
What is the pKa value of bupivicaine? correct answers 8.1
3 advantages of vascoconstrictor within local anesthetics: correct answers 1) Prolongs numbness
2) Reduces toxicity 3) Promotes hemostasis
What is considered the max epinephrine for an ASA I patient? correct answers 0.2mg
What is considered the max. epinephrine for a cardiac patient? correct answers 0.04 mmg
What is the max lidocaine without vasoconstrictor? correct answers 4.4mg/kg
