Pathophysiology : The Biologic Basis for
Disease in Adults and Children: Chapter 9:
1. Inappropriate Immune Responses may be: 1. allergy: exaggerated against
environmental antigens
2. autoimmunity: misdirected against the host's own cells
3. all immunity: directed against beneficial foreign tissues, such as transfusions or transplants
4. immune deficiency: in sufficient to protect the host
2. Which is the most common and least threatening inappropriate
immune response?: allergy
3. hypersensitivity: an altered immunologic response to an antigen that results in disease or damage to
the hose
4. Which 2 ways can hypersensitivity be classified?: 1. by source
2. by mechanism
5. allergy: -deleterious effect of hypersensitivity to environmental changes
-hypersensitivity response against environmental antigen, most are Type I
6. immunity: protective responses to antigens expressed by disease causing agents
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6
, 7. autoimmunity: -a disturbance in the immunological tolerance of self-antigens
-body's immune system begins to recognize self antigens as foreign
8. all immunity: -immune system of one individual produces an immunologic reaction against
tissues of another individual
-ex: transient neonatal diseases, transplant rejection and transfusion reactions
9. 3 variables which interact for hypersensitivity to cause disease development-
: 1. an alteration/insult in immunologic homeostasis
2. an individual's genetic makeup, which determine the degree of the resultant immune response to the insult
3. an immunologic process that causes symptoms of disease
10. 4 mechanisms of hypersensitivity reactions: -type I: immunoglobulin E (IgE) -
mediated
-type II: tissue-specific
-type III: immune-complex-mediated
type IV: cell-mediated
11. Disease is seldom associated with only 1 mechanism (no back): (no
back)
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6
Disease in Adults and Children: Chapter 9:
1. Inappropriate Immune Responses may be: 1. allergy: exaggerated against
environmental antigens
2. autoimmunity: misdirected against the host's own cells
3. all immunity: directed against beneficial foreign tissues, such as transfusions or transplants
4. immune deficiency: in sufficient to protect the host
2. Which is the most common and least threatening inappropriate
immune response?: allergy
3. hypersensitivity: an altered immunologic response to an antigen that results in disease or damage to
the hose
4. Which 2 ways can hypersensitivity be classified?: 1. by source
2. by mechanism
5. allergy: -deleterious effect of hypersensitivity to environmental changes
-hypersensitivity response against environmental antigen, most are Type I
6. immunity: protective responses to antigens expressed by disease causing agents
1/
6
, 7. autoimmunity: -a disturbance in the immunological tolerance of self-antigens
-body's immune system begins to recognize self antigens as foreign
8. all immunity: -immune system of one individual produces an immunologic reaction against
tissues of another individual
-ex: transient neonatal diseases, transplant rejection and transfusion reactions
9. 3 variables which interact for hypersensitivity to cause disease development-
: 1. an alteration/insult in immunologic homeostasis
2. an individual's genetic makeup, which determine the degree of the resultant immune response to the insult
3. an immunologic process that causes symptoms of disease
10. 4 mechanisms of hypersensitivity reactions: -type I: immunoglobulin E (IgE) -
mediated
-type II: tissue-specific
-type III: immune-complex-mediated
type IV: cell-mediated
11. Disease is seldom associated with only 1 mechanism (no back): (no
back)
2/
6
