Pharmacology VTT 244 Inhalant and Behavioral Lectures- Q&A
1. Isoflurane An inhalant with low solubility coeflcient, high vapor pressure, and MAC of
1.3-1.63%
2. Sevoflurane Inhalant with lower vapor pressure than isoflurane, requiring a precision vaporizer
designed for it
3. Nitrous oxide Used in some veterinary practices as an inhalant anesthetic
4. Mode of Action Inhalants enter and exit through lungs, inhibiting nerve function or dissolving in
nerve cell membranes
5. Effects Include reversible CNS depression, muscle relaxation, respiratory depression, car-
diac depression, and potentiation of cardiac arrhythmias
6. Contraindica- Inhalants contraindicated in malignant hyperthermia, caution in increased CSF
tions/Precau- pressure, head trauma, and myasthenia gravis
tions
7. Adverse Effects Include dose-related hypotension, anesthesia-associated myopathy in horses, and
GI ettects like nausea, vomiting, and ileus
8. Distribution/Elim- Inhalants move from lungs to brain via a concentration gradient, lipid solubility
ination allows quick entry into the brain inducing anesthesia
9. Physical Proper- Include vapor pressure, solubility coeflcient, and MAC (minimum alveolar concen-
ties tration)
10. Vapor Pressure Measure of how readily a liquid transforms into a gas, temperature dependent
11. Solubility Coeffi- Expresses agent's susceptibility to being dissolved/absorbed, low coeflcient
cient agents like Iso and Sevo allow rapid induction
12. Lowest anesthetic concentration producing no response in 50% of patients ex-
posed to a painful stimulus
1/3
1. Isoflurane An inhalant with low solubility coeflcient, high vapor pressure, and MAC of
1.3-1.63%
2. Sevoflurane Inhalant with lower vapor pressure than isoflurane, requiring a precision vaporizer
designed for it
3. Nitrous oxide Used in some veterinary practices as an inhalant anesthetic
4. Mode of Action Inhalants enter and exit through lungs, inhibiting nerve function or dissolving in
nerve cell membranes
5. Effects Include reversible CNS depression, muscle relaxation, respiratory depression, car-
diac depression, and potentiation of cardiac arrhythmias
6. Contraindica- Inhalants contraindicated in malignant hyperthermia, caution in increased CSF
tions/Precau- pressure, head trauma, and myasthenia gravis
tions
7. Adverse Effects Include dose-related hypotension, anesthesia-associated myopathy in horses, and
GI ettects like nausea, vomiting, and ileus
8. Distribution/Elim- Inhalants move from lungs to brain via a concentration gradient, lipid solubility
ination allows quick entry into the brain inducing anesthesia
9. Physical Proper- Include vapor pressure, solubility coeflcient, and MAC (minimum alveolar concen-
ties tration)
10. Vapor Pressure Measure of how readily a liquid transforms into a gas, temperature dependent
11. Solubility Coeffi- Expresses agent's susceptibility to being dissolved/absorbed, low coeflcient
cient agents like Iso and Sevo allow rapid induction
12. Lowest anesthetic concentration producing no response in 50% of patients ex-
posed to a painful stimulus
1/3
