LATEST UPDATE WITH
CORRECT ANSWERS
*SHIVERS* of Serotonin Syndrome - ANSWER --*S*hivering
*H*yperreflexia
*I*ncreased temp (fever)
*V*itals, unstable
*E*ncephalopathy
*R*estless
*S*weating
Tx: Cyproheptadine
1st line Tx of depression in children - ANSWER --Fluoxetine (Prozac)
- Longest Half-life of all SSRIs
- Caution ↑ SI in the 1st 2 weeks of use
*SIGECAPS* of Depression - ANSWER --*S*leep disturbances
*I*nterests are ↓
*G*uilt
*E*nergy is ↓
,*C*oncentration is ↓
*A*ppetite is ↓
*P*sychomotor Agitation
*S*uicidal thoughts
Major depressive disorder - ANSWER --Depressed Mood or Anhedonia
Dx: 5 or more of the SIGECAPS Sxs for *> 2 wks* effecting normal function
Tx:
*SSRI* or *SNRI* > TCA/MAOi > ECT
S/Es of SSRIs - ANSWER --*Sexual Dysfunction*
Wt gain
Anxiety
Nausea
SSRI known to cause QT interval prolongation - ANSWER --Citalopram (Celexa)
Screening tool or questionnaire used in clinic for:
Bipolar Disorder
Major Depression Disorder - ANSWER --BPD: The Mood Disorder Questionaire
MDD: Beck Depression Inventory
,Atypical Antidepressant which inhibits DA reuptake, has less sexual and wt-related side effects,
but decreases *seizure* threshold - ANSWER --Bupropion
*smoking cessation*
*SNRI Trade Names*
Effexor
Pristiq
Cymbalta
Fetzima - ANSWER --*SNRI Drug Names*
Venlafaxine
Desvenlafaxine
Duloxetine
Levomilnacipran
TCA antidepressants
*special characteristics* - ANSWER --Desipramine - selective NET inhibitor
Imipramine - tx of enuresis
Amitriptyline- tx of neuromuscular pain
Nortriptyline
*QT Interval prolongation* = arrythmias
Bipolar II - ANSWER --Dx:
MDD + Hypomania (DIG ST) < 1wk
Function in not fully compromised
, Tx: *Risperdal*
Bipolar I Disorder - ANSWER --Dx:
MDD > 2wks + Mania (DIG FAST) > 1wk
Inhibits function of daily living
Tx:
Acute Manic Episode: Antipsychotic + Mood Stabilizer
Chronic Cycle Episodes: Mood Stabilizer
Mood Stabilizers to Tx Bipolar Disorder (4) - ANSWER --Lithium
Valproic Acid (Depakote)
Carbamazepine (Tegretol)
Lamotrigine (Lamictal)
Side Effects of Lithium
*LMNOP* - ANSWER --*L*ithium Side Effects
*M*ovements (tremors)
*N*ephrotoxicity
hyp*O*thyroid
*P*regnancy problems (Ebstein's Anomoly)
Mood Stabilizer used to Tx Bipolar I Disorder w/ predominant depressed state and may cause an
*itchy rash or SJS* - ANSWER --Lamotrigine (Lamictal)