Practice Questions with Correct Detailed
Answer Explanations
• Question: A young adult has new bilateral wrist and finger joint pain with
subjective fever, no rash, and a family history of rheumatoid arthritis. Which
general pathologic process best fits?
Answer: Inflammatory
• Question: A fair-skinned, freckled patient with light hair, lots of sun
exposure, and a family history of melanoma asks about melanoma risks.
Which option is not a risk factor (as shown in the image set)?
Answer: Age
• Question: A 15-year-old has a BMI of 19.5 kg/m² and the parent is worried
about weight. What is the most appropriate response?
Answer: Reassure the mother that this is a normal body weight.
• Question: A middle-aged man has multiple small, bright red, raised lesions
on the chest/abdomen for months, not painful, no bleeding/bruising. What
should you do?
Answer: Reassure him that there is nothing to worry about.
• Question: Which symptom pattern supports inflammatory arthritis rather
than mechanical/degenerative arthritis?
, Answer: Morning stiffness lasting >30–60 minutes that improves with
activity
• Question: Which symptom pattern supports osteoarthritis rather than
rheumatoid arthritis?
Answer: Pain that worsens with activity and improves with rest, with
minimal morning stiffness
• Question: In rheumatoid arthritis, which joints are most commonly involved
early?
Answer: Small joints of the hands/wrists (often MCP/PIP) in a symmetric
pattern
• Question: What joint finding is most suggestive of osteoarthritis?
Answer: Heberden nodes (DIP) and/or Bouchard nodes (PIP)
• Question: A hot, swollen, very painful single joint with fever is most
concerning for what diagnosis that requires urgent evaluation?
Answer: Septic arthritis
• Question: Acute monoarticular arthritis with severe pain and swelling,
especially in the first MTP joint, suggests what diagnosis?
Answer: Gout
• Question: What is the mechanism behind gout flares?
Answer: Deposition of monosodium urate crystals causing intense
inflammation
• Question: Which crystal type is associated with pseudogout?
Answer: Calcium pyrophosphate crystals
• Question: What is the classic “ABCDE” warning sign set used to screen
suspicious pigmented lesions?
Answer: Asymmetry, Border irregularity, Color variation, Diameter >6 mm,
Evolving