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Mood Stabilizers (Midterm) Verified and
Updated Questions and Answers (100%
Correct Answers)
Lithium: Mechanism of Action
Answer: Mechanism of action is still poorly understood
Possible MOAs:
- Modulation Of second messengers such as phosphatidyl inositol
- Modulation of G proteins
- Regulation of gene expression for growth factors
- Interaction with downstream signal transduction cascades
Lithium: Side Effects
Answer: • Dyspepsia, nausea
• Vomiting, diarrhea
• Polyuria, polydipsia
• Weight gain
• Hair loss
• Acne, rash
• Ataxia, dysarthria, tremor
• Sedation
Lithium: Safety Considerations
Answer: Potential long-term effects on thyroid and kidney function
, Inquire through: | Professional | Confidential Support
• Euthyroid goiter or hypothyroid goiter possible with increased TSH and decreased
T4
• Monitor kidney function and thyroid function
Nephrogenic diabetes insipidus
Potential cardiac issues
• Arrythmia, cardiovascular changes, sick sinus syndrome, bradycardia, hypotension
• T-wave flattening and inversion
• Consider baseline EKG and lipid panel
Rare risk of pseudotumor cerebri and seizures
Lithium: Therapeutic Range
Answer: Has a narrow therapeutic window
• Requires monitoring Of plasma trough drug levels
Lithium: Target plasma range
Answer: • Acute treatment: generally 1.0-1.5 mEq/L
• Chronic treatment: generally 0.6-1.2 mEq/L
Lithium - Frequency of monitoring:
Answer: • Initially every 1-2 weeks until reach desired serum concentration
• First 6 months: every 2-3 months after the desired serum concentration is achieved
• >6 months and stable: every 6-12 months
• As Needed: dose change, other medication change, and illness change
• draw level 12 hours after dose
Lithium: Toxicity
Answer: Due to its narrow therapeutic window, toxic levels are near therapeutic
Mood Stabilizers (Midterm) Verified and
Updated Questions and Answers (100%
Correct Answers)
Lithium: Mechanism of Action
Answer: Mechanism of action is still poorly understood
Possible MOAs:
- Modulation Of second messengers such as phosphatidyl inositol
- Modulation of G proteins
- Regulation of gene expression for growth factors
- Interaction with downstream signal transduction cascades
Lithium: Side Effects
Answer: • Dyspepsia, nausea
• Vomiting, diarrhea
• Polyuria, polydipsia
• Weight gain
• Hair loss
• Acne, rash
• Ataxia, dysarthria, tremor
• Sedation
Lithium: Safety Considerations
Answer: Potential long-term effects on thyroid and kidney function
, Inquire through: | Professional | Confidential Support
• Euthyroid goiter or hypothyroid goiter possible with increased TSH and decreased
T4
• Monitor kidney function and thyroid function
Nephrogenic diabetes insipidus
Potential cardiac issues
• Arrythmia, cardiovascular changes, sick sinus syndrome, bradycardia, hypotension
• T-wave flattening and inversion
• Consider baseline EKG and lipid panel
Rare risk of pseudotumor cerebri and seizures
Lithium: Therapeutic Range
Answer: Has a narrow therapeutic window
• Requires monitoring Of plasma trough drug levels
Lithium: Target plasma range
Answer: • Acute treatment: generally 1.0-1.5 mEq/L
• Chronic treatment: generally 0.6-1.2 mEq/L
Lithium - Frequency of monitoring:
Answer: • Initially every 1-2 weeks until reach desired serum concentration
• First 6 months: every 2-3 months after the desired serum concentration is achieved
• >6 months and stable: every 6-12 months
• As Needed: dose change, other medication change, and illness change
• draw level 12 hours after dose
Lithium: Toxicity
Answer: Due to its narrow therapeutic window, toxic levels are near therapeutic
