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humoral: antigen receptor
B cell receptor: antibody
Humoral: Contact w/ antigen
Bind AGN w/ surface antibody
Humoral: Events afterbinding w/ specific antigen
Clone w/: Memory cells Plasma cells
Humoral: Function of effector cell
Plasma cell: Produces antibodies
Cell mediated: Antigen receptor
T cell receptor (TCR)
Cell mediated: Contact w/ antigen
APCs present AGN w/inMHC molecules
Cell mediated: Events afterbinding w/ specific antigen
Clone w/:Memory cells Effector cell
Cell mediated: Function of effector cell
Th-Produces cytokines
Tc-Kills altered cells
Origin of B cells:
Hematopoietic stem cells
Where are B cells made?
Bone marrow
What kind of lymphopoiesis does the B cells have?
antigen-independent lymphopoiesis
, With the maturation of lymphocytes, what are the 3 processes?
Proliferation
Expression
Selection
What does Antigen-independent lymphopoiesis mean?
It does not need an antigen to activate or replicate
What % of peripheral blood lymphocytes are B cells?
10-15% of peripheral blood lymphocytes
B cell CD marker CD19
Signaling to regulate B cell development & activation
B cell CD marker CD20
Thought to be involved in B cell activation
B cell CD marker CD21
Receptor for complement breakdown component
B cell CD marker CD25
Found on activated T & B cells; receptor for interleukin-2 (IL-2);it is
a growth factor made by T cells
B cell CD marker MHC II
Found on B cells; Interact w/ Th cells (T-helper); present on all
stages except on plasma cell
can be an antigen presenting cell (APC) for a T-helper cell
B cell CD marker MHC I
Found on all nucleated cells
B cell CD marker CD 45R
Found on all hematopoietic cells; involved in activation
CD16
on NK cells binds Fc of IgG
CD56
unique marker for NK cells
What NKs CD marker produces more cytokines and help support
antibody production
CD56high