NR565/NR 565 Pharmacology Week 1 Exam / with
Well-Defined Questions and Verified Answers /
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Pharmacokinetics
The study of drug absorption, distribution, metabolism, and
excretion in the body
"What the body does to the drug"
Factors that affect drug absorption (5)
Rate of dissolution
Surface area
Blood flow
Lipid solubility
PH partitioning
Factors that affect drug distribution (4)
Blood flow to tissues
Ability to exit vascular system
Blood-brain barrier
Protein-binding capacity
Pharmacodynamics
The study of biochemical and physiologic effects of drugs on the
body and the molecular mechanisms by which those effects are
produced
"What the body does to the drug"
Phamacodynamics: 3 mechanisms of action
Receptor
Enzyme
Non-selective interactions (i.e. chemo)
Types of drug therapy (7)
, Acute
Maintenance (HTN/bc)
Supplemental (insulin)
Palliative
Supportive (IV fluid)
Prophylactic
Empirical (broad-spectrum abx)
Idiosyncratic Effect
Unexpected response to medication
Tolerance
Declining response to a drug
Dependence
Physiological/psychological need for a drug; needs drug for normal
function
Addiction
Compulsive use of a drug despite negative/dangerous effects
Drug interactions: drug-drug
When 2 drugs compete for metabolizing enzymes
Drug interactions: food-drug
Grapefruit juice or leafy greens
Drug interactions: additive
1+1 = 2; both provide intended effect
Drug interactions: antagonistic
1+1 = <2; less than desired effect of one or both drugs
Drug interactions: synergistic
1+1 = >2; sum total effect is greater than if given alone (i.e.
lisinopril + HCTZ)
Drug interactions: incompatibility
1+1 does not equal 2; two IV drugs given together causing
decomposition of one or both drugs
8 rights of medication administration
Patient
Medication
Well-Defined Questions and Verified Answers /
Get it 100% Correct Answers / guaranteed Pass &
Already Rated A+
Pharmacokinetics
The study of drug absorption, distribution, metabolism, and
excretion in the body
"What the body does to the drug"
Factors that affect drug absorption (5)
Rate of dissolution
Surface area
Blood flow
Lipid solubility
PH partitioning
Factors that affect drug distribution (4)
Blood flow to tissues
Ability to exit vascular system
Blood-brain barrier
Protein-binding capacity
Pharmacodynamics
The study of biochemical and physiologic effects of drugs on the
body and the molecular mechanisms by which those effects are
produced
"What the body does to the drug"
Phamacodynamics: 3 mechanisms of action
Receptor
Enzyme
Non-selective interactions (i.e. chemo)
Types of drug therapy (7)
, Acute
Maintenance (HTN/bc)
Supplemental (insulin)
Palliative
Supportive (IV fluid)
Prophylactic
Empirical (broad-spectrum abx)
Idiosyncratic Effect
Unexpected response to medication
Tolerance
Declining response to a drug
Dependence
Physiological/psychological need for a drug; needs drug for normal
function
Addiction
Compulsive use of a drug despite negative/dangerous effects
Drug interactions: drug-drug
When 2 drugs compete for metabolizing enzymes
Drug interactions: food-drug
Grapefruit juice or leafy greens
Drug interactions: additive
1+1 = 2; both provide intended effect
Drug interactions: antagonistic
1+1 = <2; less than desired effect of one or both drugs
Drug interactions: synergistic
1+1 = >2; sum total effect is greater than if given alone (i.e.
lisinopril + HCTZ)
Drug interactions: incompatibility
1+1 does not equal 2; two IV drugs given together causing
decomposition of one or both drugs
8 rights of medication administration
Patient
Medication
