Questions and Correct Answers |
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What is the most important differential to rule out in postmenopausal
bleeding? - 🧠ANSWER ✔✔Cancer (especially endometrial)
An average cycle is how many days? - 🧠ANSWER ✔✔28 days
Range 21-35 days/3-5 weeks
How long does an average cycle last and how much blood is typically lost?
- 🧠ANSWER ✔✔4-6 days
,30 mL (not typically measured, upper limit of normal 6-80)
Amenorrhea is defined as - 🧠ANSWER ✔✔Absence of menses >6 months
If <6 months, this is just irregular menstrual bleeding and not actual
amenorrhea
Define oligomenorrhea - 🧠ANSWER ✔✔Bleeding at an interval >35 days
Define menorrhagia - 🧠ANSWER ✔✔Excessive or prolonged menstural
bleeding occurring at regular intervals
>80 cc or >7 days
Define polymenorrhea - 🧠ANSWER ✔✔Bleeding at an interval <21 days
Differentiate between ovulatory and anovulatory bleeding. - 🧠ANSWER
✔✔Ovulatory bleeding is cyclic bleeding accompanied by cyclic signs of
ovulation (tender breasts, cramping, pain) aka typical menstrual bleeding
Anovulatory bleeding is unpredictable, non-cyclic bleeding that is variable
in flow and duration. There are no signs of ovulation.
What age groups are anovulatory bleeding not uncommon in? - 🧠ANSWER
✔✔Perimenopausal
Pre-teen
,What are some differentials to consider with pregnancy related AUB? -
🧠ANSWER ✔✔Spontaneous abortion, ectopic pregnancy, placental previa
(not attached to the fundus), placenta abruptio (detaching, emergency),
trophoblastic disease, childbirth complications
What are some medications that can cause irregular bleeding? Herbals? -
🧠ANSWER ✔✔Anticoagulants, SSRIs/antipsychotics (especially Lexapro),
corticosteroids, hormonal medications, IUD, tamoxifen
Also some herbals like ginseng, gingko, soy, black cohosh
Tamoxifen has what effects on estrogen? - 🧠ANSWER ✔✔Blocks estrogen
at the breast but has a positive effect on uterus which can increase
endometrial cancer risk and therefore create AUB
Name some systemic diseases that can cause AUB. - 🧠ANSWER
✔✔thyroid disease (both hypo and hyper)
PCOS
Coagulopathies
Hepatic disease
Pituitary adenoma
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, Hypothalamic suppression (common in athletes due to low adipose)
In a woman who is not menopausal, what needs to be ruled out before
investigating other causes of AUB? - 🧠ANSWER ✔✔pregnancy always
Why is it important to assess the size, contour, and tenderness of the
uterus when doing a physical exam for someone with AUB? - 🧠ANSWER
✔✔rule out ectopic pregnancy, fibroids that you may be able to palpate
What lab are you going to make sure to add for a woman who reports she
is reporting she is changing her pad or tampon multiple times in an hour? -
🧠ANSWER ✔✔Bleeding studies: H/H, platelet count, PT, PTT
May want to consider factor VIII, von Willebrand factor antigen (referral)
A patient with AUB is also reporting nipple discharge. What is your top
differential and what lab do you want to order? - 🧠ANSWER
✔✔Prolactinoma
Order prolactin level
Who requires an endometrial biopsy if experiencing AUB? - 🧠ANSWER
✔✔All women over age 35 or with risk factors of endometrial cancer