QUESTIONS AND CORRECT ANSWERS
What is a hypersensitivity reaction? - CORRECT ANSWER An exaggerated or
misdirected immune response that causes tissue damage.
What mediates Type I hypersensitivity? - CORRECT ANSWER IgE antibodies.
What happens in Type I hypersensitivity? - CORRECT ANSWER IgE binds mast cells
→ allergen exposure → histamine release.
Examples of Type I hypersensitivity? - CORRECT ANSWER Hay fever, asthma,
urticaria, anaphylaxis.
Treatment for anaphylaxis? - CORRECT ANSWER Epinephrine.
Symptoms of allergic rhinitis? - CORRECT ANSWER Sneezing, runny nose,
congestion, watery eyes.
What is urticaria? - CORRECT ANSWER Hives with wheal-and-flare rash.
What defines Type II hypersensitivity? - CORRECT ANSWER Antibodies attack
specific cells or tissues.
Example of Type II hypersensitivity? - CORRECT ANSWER Graves disease.
Pathophysiology of Graves disease? - CORRECT ANSWER Autoantibodies stimulate
thyroid hormone production.
, What is exophthalmos? - CORRECT ANSWER Bulging eyes due to thyroid
autoimmune swelling.
What causes Type III hypersensitivity? - CORRECT ANSWER Circulating immune
complex deposition.
Difference between Type II and III hypersensitivity? - CORRECT ANSWER Type II =
antibodies on cells; Type III = circulating complexes.
Example of Type III hypersensitivity? - CORRECT ANSWER Raynaud phenomenon.
Raynaud color sequence? - CORRECT ANSWER White → Blue → Red.
Trigger for Raynaud attacks? - CORRECT ANSWER Cold exposure or stress.
What mediates Type IV hypersensitivity? - CORRECT ANSWER T lymphocytes.
Why is Type IV delayed? - CORRECT ANSWER Takes 24-72 hours for T-cell
activation.
Examples of Type IV reactions? - CORRECT ANSWER TB skin test (PPD), poison
ivy, contact dermatitis.
Two characteristics of adaptive immunity? - CORRECT ANSWER Inducible and
memory.
What is an allergen? - CORRECT ANSWER Environmental antigen causing allergy.
Common allergens? - CORRECT ANSWER Pollen, molds, foods, animals, dust.