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NURS 5357 Neurobiology Exam 1 – 60 Questions, Schizophrenia, Neurotransmitters, Brain Pathways

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This document contains approximately 60 exam-style questions and verified answers for NURS 5357 Neurobiology Exam 1, focusing on foundational neurobiology concepts and psychiatric neuroscience. It covers key topics such as the dopamine hypothesis of schizophrenia, glutamate and serotonin pathways, brain structures and functions, neurotransmitter systems, epigenetics, and neurodevelopmental processes, as seen throughout the questions (e.g., psychosis hypotheses on page 1 and dopamine pathway mechanisms on page 2). The material is structured to support deep understanding of both basic neuroscience and its clinical application in psychiatric disorders. It includes high-yield concepts such as mesolimbic and mesocortical pathways, NMDA receptor function, synaptic transmission, and symptom classification in schizophrenia (positive vs. negative symptoms). The content aligns closely with widely used graduate-level textbooks such as Stahl’s Essential Psychopharmacology and neurobiology-focused nursing resources, integrating pharmacologic and pathophysiologic principles essential for advanced practice. This resource is ideal for students enrolled in psychiatric mental health nurse practitioner (PMHNP) programs, advanced neuroscience or neurobiology nursing courses, and Doctor of Nursing Practice (DNP) or Master of Science in Nursing (MSN) programs. It is also highly relevant for students preparing for psychiatric certification exams, as well as medical students, psychology students, and healthcare professionals seeking a concise but comprehensive review of neurobiological mechanisms underlying mental health disorders. Keywords: neurobiology, schizophrenia, dopamine hypothesis, glutamate NMDA receptor, serotonin 5HT2A, brain pathways, mesolimbic pathway, mesocortical pathway, neurotransmitters, epigenetics, synaptic transmission, neurodevelopment, psychopharmacology, psychiatric nursing

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NURS 5357 Neurobiology Exam
1 Questions with 100% Correct
Answers | Verified | Updated
(Actual Exam) 2025\2026
LATEST VERSION!!

What are the three major hypotheses of psychosis and their

neurotransmitter networks? - 🧠 ANSWER ✔✔Dopamine theory -

hyperactive dopamine at D2 receptors in the mesolimbic pathway

Glutamate theory - NMDA receptor hypofunction

Serotonin theory - 5HT2A receptor hyperfunction in the cortex

, Briefly explain the dopamine hypothesis of the positive and negative

symptoms of schizophrenia. - 🧠 ANSWER ✔✔The dopamine hypothesis of

schizophrenia consists of:

There is too much dopamine activity in the mesolimbic dopamine pathway,

which leads to positive symptoms (such as hallucinations and delusions).

There is also too little dopamine activity in the mesocortical dopamine

pathway, which leads to negative symptoms (such as blunting of affect,

poverty of speech, anhedonia, and so on).

What pathway is responsible for regulating dopamine in the hypothalamus

and affects the release of prolactin? - 🧠 ANSWER ✔✔Tuberoinfundibular

pathway

Drug-induced Parkinson's is caused by a decrease of dopamine in what

pathway? - 🧠 ANSWER ✔✔Nigrostriatal pathway


Brodmann's areas are differentiated by the: - 🧠 ANSWER ✔✔Cellular

architecture

All of the following are true about the hippocampus except that it: - 🧠

ANSWER ✔✔Is disrupted by frontal lobotomy

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