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Terms in this set (79)
Inflammatory Response -Sequential response to cell injury
-establishes an environment for healing and repair
-Inflammation is always present w/ infection**
-->infection not always present w/ inflammation
vascular response initial vascular constriction followed by chemical
mediated (histamine) vasodilation/capillary
permeability (redness,swelling, heat)
cellular response -neutrophils & monocytes
-neutrophils first to arrive, phagocytize bacteria and
foreign objects
-dead neutrophils and bacteria are pus
-monocytes transform into macrophages and clean
area for healing
-lymphocytes arrive later, humoral and cell mediated
immunity
chemical mediators -complement system: enzyme cascade mediates
inflammation
-prostaglandins&leukotrienes: think of meds to tx
inflammation (leukotriene inhibitors)
, clinical manifestations of inflammation -heat
-redness
-pain
-swelling
-loss of function (due to pain&swelling)
-increase and 'shift to the left'** (infection due to
increase in WBC)
-Fever
--> not present in immunocompromised pt (cancer,
chemo, HIV/AIDs, transplant)
small increases in temp. may be a red flag and should
be assessed!
Tx for inflammation -RICE
Rest, Ice, Compression & immobilization, Elevation)
-NSAIDs (advil, aleve)
-Tylenol
Wound healing -Regeneration: replacement of lost cells and tissues
w/ the same type
-Repair: lost cells replaced w/ connective tissue, scar
formation
Primary, secondary, tertiary intention -Primary intention: rapid healing, no infection,
healing suture/staples(surgical cut)
-Secondary intention: heal by granulation(burns,
pressure ulcers) risk for infection, scarring, repair is
longer
-Tertiary intention: wound is left open to heal, heal
from inside out ex: abdominal wound for drainage
local/disseminated/systemic infections -local: cut on finger and infected
-disseminated: cut finger, out in country for a week,
no abx, arm is infected
-systemic: sepsis, infection in blood
--> tachycardia, infection, fever